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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Kelch-like ECH-associated protein 1

Keap1, Kelch-like ECH-associated protein 1
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Keap1 antibodies
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.
Oresic Matej, In PLoS ONE, 2009
... to those used to generate the crystal structures of mouse ProTĪ± and Neh2 bound to Keap1 (PDB ids: 2Z32 and 1X2R respectively) ...
Papers on Keap1
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Yamamoto et al., Sendai, Japan. In Proc Natl Acad Sci U S A, 2012
The autophagy pathway maintains the integrity of the Keap1-Nrf2 system for the normal liver function by governing the Keap1 turnover
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.
Shinohara et al., Omaha, United States. In Biochem Biophys Res Commun, 2012
the failure of antioxidant protection due to demethylation of the CpG islands in the Keap1 promoter is linked to the diabetic cataracts and possibly age-related cataracts.
Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
Johnson et al., Madison, United States. In Neurotoxicology, 2012
Activation of endogenous intracellular levels of Nrf2 by siRNA knockdown of Keap1 is sufficient to protect in models of oxidative stress and Parkinson's disease.
Somatic mutations of the KEAP1 gene in common solid cancers.
Lee et al., Seoul, South Korea. In Histopathology, 2012
KEAP1 mutations occur widely in solid cancers, irrespective of histological type.
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus.
Chen et al., Durham, United States. In Plos One, 2011
Morphological changes of the esophageal epithelium are associated with dynamic changes in gene expression. Nrf2/Keap1 pathway activity is required for maturation of mouse esophageal epithelium.
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