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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kelch-like ECH-associated protein 1

Keap1, Kelch-like ECH-associated protein 1
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nrf2, CAN, V1a, NF-E2, ACID
Papers using Keap1 antibodies
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.
Supplier
Oresic Matej, In PLoS ONE, 2009
... to those used to generate the crystal structures of mouse ProTα and Neh2 bound to Keap1 (PDB ids: 2Z32 and 1X2R respectively) ...
Papers on Keap1
Enhanced muscle nutrient content and flesh quality, resulting from tryptophan, is associated with anti-oxidative damage referred to the Nrf2 and TOR signalling factors in young grass carp (Ctenopharyngodon idella): Avoid tryptophan deficiency or excess.
New
Feng et al., Chengdu, China. In Food Chem, Jun 2016
The expression of signalling molecules [Kelch-like ECH-associated protein 1, target of rapamycin (TOR) and ribosomal S6 protein kinase 1] involved in the NF-E2-related factor 2 (Nrf2) pathway revealed a potential method of Trp-enhanced antioxidant defence.
Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes.
Review
New
Fukushima et al., Obihiro, Japan. In World J Gastroenterol, Feb 2016
These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1-NF-E2-related factor-2 pathway and antioxidant responsive elements.
Application of mass spectrometry profiling to establish brusatol as an inhibitor of global protein synthesis.
New
Stokoe et al., United States. In Mol Cell Proteomics, Jan 2016
UNASSIGNED: The KEAP1/Nrf2 pathway senses and responds to changes in intracellular oxidative stress.
A mechanism for the suppression of homologous recombination in G1 cells.
New
Impact
Durocher et al., Toronto, Canada. In Nature, Jan 2016
We found that the BRCA1-interaction site on PALB2 is targeted by an E3 ubiquitin ligase composed of KEAP1, a PALB2-interacting protein, in complex with cullin-3 (CUL3)-RBX1 (ref.
Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain.
New
Lei et al., Beijing, China. In Sci Rep, Dec 2015
We have also identified a more potent natural product analogue J19-1 by semisynthesis and the subsequent biochemical evaluations revealed that J19-1 activates the Nrf2 pathway by covalently modifying Cys171 of keap1, which inhibits Nrf2 degradation mediated by Keap1-Cul3 complexes.
Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.
New
Zhang et al., Tucson, United States. In Sci Rep, Dec 2015
In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal (IP) injection of bixin led to pulmonary upregulation of the NRF2 response in vivo.
Estrogen potentiates reactive oxygen species (ROS) tolerance to initiate carcinogenesis and promote cancer malignant transformation.
Review
New
Zheng et al., Xuzhou, China. In Tumour Biol, Dec 2015
On the other hand, estrogen simultaneously performs the antioxidative beneficial functions, which protects cancer cells from the potential cytotoxic effects of estrogen-mediated ROS through activation of nuclear factor-erythroid-2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) antioxidant response.
Attenuation of oxygen fluctuation-induced endoplasmic reticulum stress in human lens epithelial cells.
New
Wang et al., Hangzhou, China. In Exp Ther Med, Nov 2015
Reverse transcription-quantitatative polymerase chain reaction assays were performed to quantify the mRNA levels of activated NF-E2-related factor 2 (Nrf2) and kelch-like ECH-associated protein 1 (Keap1).
[Recent advances in the study of Nrf2 and inflammatory respiratory diseases].
Review
New
Hou et al., In Yao Xue Xue Bao, Sep 2015
A large body of research showed that Nrf2-Keap1 (Kelch-like ECH-associated protein 1, Keap 1)-ARE signaling pathway is involved in the endogenous antioxidant defense mechanisms.
Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention.
Review
New
Zhang et al., Tucson, United States. In Biochem Soc Trans, Sep 2015
Detailed mechanistic investigations have shown the Kelch-like ECH-associated protein 1 (Keap1)-cullin3 (Cul3)-ring-box1 (Rbx1) E3-ligase to be the primary Nrf2 regulatory system.
Hormesis: Decoding Two Sides of the Same Coin.
Review
Efferth et al., Thanjāvūr, India. In Pharmaceuticals (basel), 2014
We talk about common pathways through which cancer progresses (such as nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1), sirtuin-forkhead box O (SIRT-FOXO) and others), analyzing how diverse molecules associated with these pathways conform to hormesis.
Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.
Impact
Park et al., Seoul, South Korea. In J Clin Oncol, 2014
Seven genes demonstrated statistical enrichment for mutation: TP53, RB1, PTEN, NFE2L2, KEAP1, MLL2, and PIK3CA).
Integrated molecular analysis of clear-cell renal cell carcinoma.
Impact
Ogawa et al., Tokyo, Japan. In Nat Genet, 2013
Other newly identified pathways and components recurrently mutated in ccRCC included PI3K-AKT-mTOR signaling, the KEAP1-NRF2-CUL3 apparatus, DNA methylation, p53-related pathways and mRNA processing.
Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy.
Review
Impact
Paik et al., New York City, United States. In Lancet Oncol, 2012
Additionally, evidence of unique biology has emerged with the discovery of SOX2 amplification, NFE2L2 and KEAP1 mutations, PI3K pathway changes, FGFR1 amplification, and DDR2 mutations.
Comprehensive genomic characterization of squamous cell lung cancers.
Impact
Cancer Genome Atlas Research Network, Cambridge, United States. In Nature, 2012
Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours.
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
GeneRIF
Yamamoto et al., Sendai, Japan. In Proc Natl Acad Sci U S A, 2012
The autophagy pathway maintains the integrity of the Keap1-Nrf2 system for the normal liver function by governing the Keap1 turnover
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.
GeneRIF
Shinohara et al., Omaha, United States. In Biochem Biophys Res Commun, 2012
the failure of antioxidant protection due to demethylation of the CpG islands in the Keap1 promoter is linked to the diabetic cataracts and possibly age-related cataracts.
Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
GeneRIF
Johnson et al., Madison, United States. In Neurotoxicology, 2012
Activation of endogenous intracellular levels of Nrf2 by siRNA knockdown of Keap1 is sufficient to protect in models of oxidative stress and Parkinson's disease.
Somatic mutations of the KEAP1 gene in common solid cancers.
GeneRIF
Lee et al., Seoul, South Korea. In Histopathology, 2012
KEAP1 mutations occur widely in solid cancers, irrespective of histological type.
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus.
GeneRIF
Chen et al., Durham, United States. In Plos One, 2011
Morphological changes of the esophageal epithelium are associated with dynamic changes in gene expression. Nrf2/Keap1 pathway activity is required for maturation of mouse esophageal epithelium.
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