Scutellaria barbata D. Don inhibits tumor angiogenesis via suppressing proliferation, migration and tube formation of endothelial cells and downregulating the expression of VEGF-A in cancer cellsmore suppliers
In International Journal of Molecular Sciences, 2010
... CD31, SHH, PTCH-1, SMO, Gli-1, VEGF-A and VEGFR2 antibodies, secondary antibodies were obtained from Cell Signaling (Beverly, MA, USA) ...
Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.
Villejuif, France. In N Engl J Med, Dec 2015
BACKGROUND: Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) as well as MET and AXL, each of which has been implicated in the pathobiology of metastatic renal-cell carcinoma or in the development of resistance to antiangiogenic drugs.
Treatment of advanced squamous cell carcinoma of the lung: a review.
Chicago, United States. In Transl Lung Cancer Res, Oct 2015
Current studies have confirmed an expanding role for immunotherapy [including programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibition], a potential opportunity for VEGFR inhibition, and even future targets in fibroblast growth factor receptor (FGFR) and PI3K-AKT that collectively should improve survival as well as quality of life for those affected by squamous cell lung cancer over the next decade.
Endophilin marks and controls a clathrin-independent endocytic pathway.
Cambridge, United Kingdom. In Nature, Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Overview of fundamental study of pazopanib in cancer.
More papers using
Tianjin, China. In Thorac Cancer, 2014
In vivo xenograft studies and phase I/II clinical trials revealed a series of plasma cytokine and angiogenic factors, such as interleukin (IL)-6, IL-12, hepatocyte growth factor (HGF), and soluble VEGFR2, which have significant association with clinical curative effect.
Gastrointestinal stromal tumors: chemotherapy and
In Rare Tumors, 2001
... immunohistochemically using antibodies recognizing vascular endothelial growth factor receptor 2 (VEGFR2, 1:200, R&D-Systems, Wiesbaden, Germany), stem cell growth factor receptor (c-kit, 1:20, Dako, Hamburg, Germany), platelet-derived ... VEGF receptor signal transduction.
In PLoS ONE, 2000
... Signaling #9102); rabbit anti-phospho-PLC-γ (Tyr 783, Cell Signaling #2821S); rabbit anti-PLC-γ (Cell Signaling #2822); rabbit anti-phospho-VEGFR2 (Tyr 951, Cell Signaling #4991S; Tyr 1054 Upstate ...