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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Kinase insert domain receptor

KDR, Vascular Endothelial Growth Factor Receptor-2, Flk-1, VEGFR-2, VEGFR
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, Flt-1, V1a, HAD
Papers using KDR antibodies
Scutellaria barbata D. Don inhibits tumor angiogenesis via suppressing proliferation, migration and tube formation of endothelial cells and downregulating the expression of VEGF-A in cancer cells
Supplier
Peng Jun et al., In International Journal of Molecular Sciences, 2010
... CD31, SHH, PTCH-1, SMO, Gli-1, VEGF-A and VEGFR2 antibodies, secondary antibodies were obtained from Cell Signaling (Beverly, MA, USA) ...
Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease.
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Conklin Daniel J. et al., In Environmental Health Perspectives, 2009
... label bone marrow-derived cells (BMDCs), fixed cells were incubated with FITC-Sca-1 (1:25; BD BioSciences) and APC-Flk-1 (1:15, BD BioSciences) antibodies (1 hr at ...
Extracellular superoxide dismutase is a growth regulatory mediator of tissue injury recovery.
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Stadler Krisztian, In PLoS ONE, 2008
... Antibodies to phospho-VEGFR2 (pY1175) were from Cell Signaling.
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration
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Stetler-Stevenson William George et al., In Laboratory investigation; a journal of technical methods and pathology, 2007
... Anti-VEGFR-2 antibody was obtained from Santa Cruz Biotechnology (Santa Cruz, CA).
Arterial-venous endothelial cell fate is related to vascular endothelial growth factor and Notch status during human bone mesenchymal stem cell differentiation
Supplier
Kielty Cay M. et al., In Stem Cell Research, 2007
... adhesion molecule-1 (PECAM-1) (89C2) (3528), rabbit anti-human vascular endothelial cadherin (VE-cadherin) (2158) and rabbit anti-human VEGFR2 (55B11) (2479) were all from Cell Signaling Technology ...
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Papers on KDR
Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor.
New
Cheung et al., Salt Lake City, United States. In J Vasc Res, Feb 2016
RESULTS: In an in vivo porcine model, PDGF, VEGF and their receptors PDGFR-α and VEGFR-2 were upregulated at the venous anastomosis within 2 weeks after AVG placement, with NH development by 4 weeks.
Fully quantified spectral imaging reveals in vivo membrane protein interactions.
New
Hristova et al., Baltimore, United States. In Integr Biol (camb), Feb 2016
We use the FSI method to study the lateral interactions of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), a member of the receptor tyrosine kinase (RTK) superfamily, in plasma membranes, in vivo.
Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs.
Review
New
Ouyang et al., Shenyang, China. In Eur J Med Chem, Jan 2016
UNASSIGNED: Vascular endothelial growth factor receptor (VEGFR) is a very important receptor tyrosine kinase (RTK) that can induce angiogenesis, increase cell growth and metastasis, reduce apoptosis, alter cytoskeletal function, and affect other biologic changes.
Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing.
New
Pasquinelli et al., Bologna, Italy. In Stem Cells Int, Dec 2015
HGF/SF did not increase hVW-MSC proliferation, whereas it enhanced the cell migration, the formation of capillary-like structures, and the expression of angiogenic markers (vWF, CD31, and KDR).
Characterization of the expression and clinical features of epidermal growth factor receptor and vascular endothelial growth factor receptor-2 in esophageal carcinoma.
New
Awut et al., Ürümqi, China. In Oncol Lett, Dec 2015
UNASSIGNED: The present study aimed to understand the expression characteristics of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2) in individuals of Uygur, Han and Kazak ethnicity with esophageal carcinoma in Xinjiang (China) and their interrelation analysis, and to investigate the expression differences in these genes between esophageal carcinoma and pericarcinoma tissue samples, and between the three ethnic groups.
Prognostic value of vascular endothelial growth factor-C and podoplanin mRNA expression in esophageal cancer.
New
Nikliński et al., Białystok, Poland. In Oncol Lett, Dec 2015
UNASSIGNED: Vascular endothelial growth factor-C (VEGF-C), VEGF-D, VEGF receptor-3 (VEGFR-3) and podoplanin (PDPN) are involved in the spread of cancer.
Systemic therapy beyond first-line in advanced gastric cancer: An overview of the main randomized clinical trials.
Review
New
Fazio et al., Milano, Italy. In Crit Rev Oncol Hematol, Dec 2015
Combination of weekly paclitaxel and ramucirumab, a novel anti-angiogenic VEGFR2 antibody, pushes the overall survival up to over 9.5 months, whereas apatinib, a novel oral VEGFR2 tyrosine kinase inhibitor, seems to be promising in heavily pretreated patients.
Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.
New
Impact
METEOR Investigators et al., Villejuif, France. In N Engl J Med, Dec 2015
BACKGROUND: Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) as well as MET and AXL, each of which has been implicated in the pathobiology of metastatic renal-cell carcinoma or in the development of resistance to antiangiogenic drugs.
Treatment of advanced squamous cell carcinoma of the lung: a review.
Review
New
Fidler et al., Chicago, United States. In Transl Lung Cancer Res, Oct 2015
Current studies have confirmed an expanding role for immunotherapy [including programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibition], a potential opportunity for VEGFR inhibition, and even future targets in fibroblast growth factor receptor (FGFR) and PI3K-AKT that collectively should improve survival as well as quality of life for those affected by squamous cell lung cancer over the next decade.
VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection.
New
Impact
Bell et al., Ottawa, Canada. In Cancer Cell, Sep 2015
VEGF/VEGFR2 signaling through Erk1/2 and Stat3 leads to upregulation, nuclear localization, and activation of the transcription repressor PRD1-BF1/Blimp1.
VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature.
Review
New
Săftoiu et al., In Rom J Intern Med, Jul 2015
VEGF protein family currently comprises several members: VEGF (or VEGF-A), VEGF-B, VEGF-C and VEGF-D, VEGF-F, placental growth factor (PlGF), and their receptors VEGFR-1, VEGFR-2 and VEGFR-3.
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.
New
Impact
Wennerberg et al., Helsinki, Finland. In Nature, Apr 2015
Here we combine comprehensive drug sensitivity and resistance profiling of patient cells ex vivo with structural analysis to establish the VEGFR tyrosine kinase inhibitor axitinib as a selective and effective inhibitor for T315I-mutant BCR-ABL1-driven leukaemia.
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Overview of fundamental study of pazopanib in cancer.
Review
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
In vivo xenograft studies and phase I/II clinical trials revealed a series of plasma cytokine and angiogenic factors, such as interleukin (IL)-6, IL-12, hepatocyte growth factor (HGF), and soluble VEGFR2, which have significant association with clinical curative effect.
Neurons limit angiogenesis by titrating VEGF in retina.
Impact
Kubota et al., Tokyo, Japan. In Cell, 2014
VEGFR2, a critical endothelial receptor for VEGF, was more abundantly expressed in retinal neurons than in endothelial cells, including endothelial tip cells.
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
GeneRIF
Morello et al., Italy. In Arterioscler Thromb Vasc Biol, 2012
Pharmacological activation of endothelial LXRs reduces angiogenesis by restraining cholesterol-dependent vascular endothelial growth factor receptor-2 compartmentation and signaling.
Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice.
GeneRIF
Fong et al., Farmington, United States. In Circulation, 2012
Upregulation of VEGFR-2 abundance at the protein level contributes in part to increased angiogenesis in VEGFR-1-deficient mice.
VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.
Impact
GeneRIF
Bergers et al., San Francisco, United States. In Cancer Cell, 2012
demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment of the protein tyrosine phosphatase 1B (PTP1B) to a MET/VEGFR2 heterocomplex
SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.
GeneRIF
Wei et al., Boston, United States. In J Exp Med, 2012
Data show that beta-TRCP knockdown causes accumulation of VEGFR2, resulting in increased activity of signaling pathways downstream of VEGFR2.
The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis.
GeneRIF
Ahmed et al., Edinburgh, United Kingdom. In Nat Commun, 2011
The findings indicate that VEGFR-1 subunits modulate VEGF activity predominantly by forming heterodimer receptors with VEGFR-2 subunits and such heterodimers regulate endothelial cell homeostasis.
More papers using KDR antibodies
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
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Perez-Gracia J L et al., In British Journal of Cancer, 2007
... Purified anti-VEGFR-1 and VEGFR-2 mAbs were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
The blood-brain barrier in health and chronic neurodegenerative disorders
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Brito Maria A. et al., In Frontiers in Cellular Neuroscience, 2007
... Horseradish peroxidase-labeled goat anti-rabbit IgG, mouse anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH), rabbit anti-VEGF, and mouse anti-VEGFR-2 were acquired from Santa Cruz Biotechnology, Inc ...
Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
Supplier
Eibl Guido et al., In Molecular Imaging and Biology, 2004
... Rat anti-mouse PECAM-1 (CD-31) antibody was purchased from Angio-Proteomie (mAP-0032, Boston, MA, USA), and rabbit anti-VEGFR2 antibody was from Cell Signaling Technology, Inc ...
Assessing microvessels and angiogenesis in human breast cancer, using VE-cadherin.
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Fadini Gian Paolo, In PLoS ONE, 2004
... VEGFA neutralizing antibody was obtained from (R&D Systems, Minneapolis, MN, USA) and VEGFR-1 and VEGFR-2 neutralizing antibodies were obtained from Santa Cruz Biotechnology Inc ...
Cathelicidins, multifunctional peptides of the innate immunity
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Ståhle M et al., In Oncogene, 2003
... (PY99), ubiquitin (P4D1) and polyclonal antibodies against IGF-1R (H-60), GAPDH (FL-335), β-arrestin-1 (K-16), PDGFR (C-20), VEGFR, mouse immunoglobulin G, rabbit immunoglobulin G and IR-α were from Santa Cruz Biotechnology Inc ...
IQGAP proteins are integral components of cytoskeletal regulation.
Supplier
Gay Nick, In PLoS ONE, 2002
... Rabbit monoclonal anti-phospho-VEGFR-2 (pY1173) was purchased from Cell Signaling Technology (Beverly, MA) ...
Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly
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Ganjoo Kristen et al., In Case Reports in Oncology, 2002
... unit # sc-7603), mouse anti-human VEGFR1 monoclonal antibody (Santa Cruz Biotechnology, Inc.; unit # sc-65442), rabbit anti-human VEGFR2 polyclonal antibody (Abcam, Cambridge, UK; unit # ab45010), ...
Gastrointestinal stromal tumors: chemotherapy and imatinib
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K. Breuhahn et al., In Rare Tumors, 2001
... immunohistochemically using antibodies recognizing vascular endothelial growth factor receptor 2 (VEGFR2, 1:200, R&D-Systems, Wiesbaden, Germany), stem cell growth factor receptor (c-kit, 1:20, Dako, Hamburg, Germany), platelet-derived ...
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148
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Dejana Elisabetta et al., In The Journal of Cell Biology, 2001
... ), and expression of VEGFR-2 was tested with sc504 by Santa Cruz Biotechnology, Inc ...
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
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Bhatia Mickie et al., In The Journal of Experimental Medicine, 2000
... Single cells dissociated from d 10 hEBs were stained with human PECAM-1 or Flk-1-FITC (BD Biosciences) and CD45-APC (Becton Dickinson), ...
Covalently conjugated VEGF—fibrin matrices for endothelialization
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Iruela-Arispe M. Luisa et al., In The Journal of Cell Biology, 2000
... For the detection of internalized VEGFR2, anti–human VEGFR2 (single-chain recombinant; clone scFvA7 with E tag; RDI and Fitzgerald) in combination with rabbit ...
Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)
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Zachary I et al., In British Journal of Cancer, 2000
... Antibodies against NRP1, NRP2, VEGFR-1, and VEGFR-2 were purchased from Santa Cruz Biotechnology Inc ...
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
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Dejana Elisabetta et al., In The Journal of Cell Biology, 2000
... For the detection of VEGFR-2, anti–human VEGFR-2 (single chain recombinant; clone scFvA7 with E tag; RDI and Fitzgerald) and anti–mouse VEGFR-2 (rat ...
VEGF receptor signal transduction.
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Kume Tsutomu, In PLoS ONE, 2000
... Signaling #9102); rabbit anti-phospho-PLC-γ (Tyr 783, Cell Signaling #2821S); rabbit anti-PLC-γ (Cell Signaling #2822); rabbit anti-phospho-VEGFR2 (Tyr 951, Cell Signaling #4991S; Tyr 1054 Upstate ...
Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
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Dimmeler Stefanie et al., In The Journal of Experimental Medicine, 1997
... cells were incubated with biotinylated Flk-1 antibodies (DSB-X biotin protein labeling kit; Molecular Probes; antibody was obtained from BD Biosciences) for 30 min at ...
Consumption of dairy produce and alcohol in a case-control study of breast cancer
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Bieberich Erhard et al., In Breast Cancer Research : BCR, 1985
... DC and the VEGF receptor (VEGFR)2/Flk-1 antagonist SU5416 was from Sigma Aldrich (St ...
Architecture of the human lung. Use of quantitative methods establishes fundamental relations between size and number of lung structures
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Snyder Brian D. et al., In Clinical Orthopaedics and Related Research, 1961
... VEGFR-2Angiogenesis signalingSanta Cruz Biotechnology Inc, Santa Cruz, CA ...
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