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Potassium channel tetramerisation domain containing 10

KCTD10, potassium channel tetramerisation domain-containing 10
Top mentioned proteins: PDIP1, PCNA, CAN, POLYMERASE, mevalonate kinase
Papers on KCTD10
Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study.
Crawford et al., Nashville, United States. In Invest Ophthalmol Vis Sci, 2014
Four lipid-associated SNPS (LPL rs328, TRIB1 rs6987702, CETP rs1800775, and KCTD10/MVK rs2338104) were associated with AMD in African Americans and Mexican Americans (P<0.05), but these associations did not survive strict corrections for multiple testing.
KCTD10 is critical for heart and blood vessel development of zebrafish.
Zhang et al., Changsha, China. In Acta Biochim Biophys Sin (shanghai), 2014
KCTD10 is a member of the PDIP1 family, which is highly conserved during evolution, sharing a lot of similarities among human, mouse, and zebrafish.
Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish.
Zhang et al., Beijing, China. In Nat Commun, 2013
The affected gene is identified as kctd10, a member of the potassium channel tetramerization domain (KCTD)-containing family.
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
Zhang et al., Changsha, China. In Plos One, 2013
As a member of the polymerase delta-interacting protein 1 (PDIP1) gene family, potassium channel tetramerisation domain-containing 10 (KCTD10) interacts with proliferating cell nuclear antigen (PCNA) and polymerase δ, participates in DNA repair, DNA replication and cell-cycle control.
Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development.
Baranova et al., Moscow, Russia. In Bioessays, 2013
In particular, we predict that KCTD20 participates in the AKT-mTOR-p70 S6k signaling cascade, KCTD5 plays a role in cytokinesis in a NEK6 and ch-TOG-dependent manner, KCTD10 regulates the RhoA/RhoB pathway.
Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor.
Kondo et al., Tokyo, Japan. In Plos One, 2012
We also examined the clinical utility and functions of its downstream gene, potassium channel tetramerization domain containing protein 10 (KCTD10).
TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.
Zhang et al., Changsha, China. In Mol Biol Rep, 2012
Potassium channel tetramerisation domain containing 10 (KCTD10) was identified as TNFAIP1-interacting partner.
Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK.
Mohlke et al., Chapel Hill, United States. In Hum Mol Genet, 2010
In contrast, MVK, UBE3B, KCTD10 and ACACB did not show significant AEI (P > or = 0.05).
Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.
GeneRIF
Ordovás et al., Boston, United States. In Am J Clin Nutr, 2009
For the SNPs KCTD10_i5642G-->C and MVK_S52NG-->A, homozygotes for the major alleles (G) had lower HDL-cholesterol concentrations than did carriers of the minor alleles (P = 0.005 and P = 0.019, respectively).
KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation.
GeneRIF
Hui et al., Beijing, China. In J Cell Biochem, 2009
KCTD10 may be associated with DNA synthesis and cell proliferation
The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.
Zhang et al., Nanjing, China. In J Cell Biochem, 2009
Transient transfection assays using four promoters containing AP-2-binding sites confirmed that KCTD1 significantly repressed AP-2alpha-mediated transactivation through the BTB domain, whereas KCTD1 siRNA strongly relieved KCTD1-mediated repression of AP-2alpha transcriptional activity, and other BTB domain proteins such as PDIP1, KCTD10, and TNFAIP1 did not markedly inhibit the transcriptional activity of AP-2alpha, suggesting that KCTD1 specifically acts as a negative regulator of AP-2alpha.
Transcription factor specificity protein 1 (SP1) and activating protein 2alpha (AP-2alpha) regulate expression of human KCTD10 gene by binding to proximal region of promoter.
GeneRIF
Zhang et al., China. In Febs J, 2009
binding of SP1 to the proximal promoter region stimulated the promoter activity and endogenous KCTD10 expression, whereas binding of AP-2alpha to this region showed opposite effects.
[Preparation of mouse KCTD10 antibody and expression analysis of KCTD10 in neuroepithelium of neural tube and dorsal root ganglion].
Zhou et al., Changsha, China. In Sheng Wu Gong Cheng Xue Bao, 2007
KCTD10 is a TNF-alpha inducible protein that can interact with the small subunit of DNA polymerase a and PCNA.
A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta.
Zhang et al., Changsha, China. In Biochim Biophys Acta, 2005
Rat potassium channel tetramerisation domain-containing 10 (KCTD10) gene was cloned and identified as a novel member of polymerase delta-interacting protein 1 (PDIP1) gene family.
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