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Potassium large conductance calcium-activated channel, subfamily M beta member 3

KCNMB3, hbeta3, KCNMB2, hbeta2, hKCNMB3
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: beta2, hbeta4, KCNMB1, HAD, beta-4
Papers on KCNMB3
Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells.
New
Chapman et al., Sheffield, United Kingdom. In Mol Hum Reprod, Nov 2015
DNA sequences in these regions, from both unstimulated or TNF-stimulated PHM1-31 cultures, were associated with genic regions including IκBα, COX-2, IL6RN, Jun and KCNMB3.
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
Montine et al., Miami, United States. In Plos Genet, 2014
GalNAc transferase 7 (GALNT7), ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1), and an intergenic region on chromosome 9 were associated with NP score; and Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 2 (KCNMB2) was strongly associated with HS.
IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction.
Salathe et al., Miami, United States. In Am J Physiol Lung Cell Mol Physiol, 2014
IFN-γ changed mRNA levels of the BK β-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased).
Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance.
Lai et al., Hangzhou, China. In Plos One, 2012
BACKGROUND: Neighboring genes PIK3CA and KCNMB3 are both important for insulin signaling and β-cell function, but their associations with glucose-related traits are unclear.
A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts.
Evans et al., Cardiff, United Kingdom. In Am J Physiol Cell Physiol, 2009
RT-PCR showed the presence of KCNMA1, KCNMB1, KCNMB2, KCNMB3, and KCNMB4 subunits.
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia.
GeneRIF
Cui et al., Saint Louis, United States. In J Physiol, 2009
Report beta subunit (KNMB1-4)-specific modulations of BK channel function by a Slo1 mutation associated with epilepsy and dyskinesia.
Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2-q29 in squamous cell carcinoma of the lung.
Kim et al., New York City, United States. In Bmc Cancer, 2008
In addition, we identified the following possible target genes (> 30% of patients) at 3q26.2-q29: LOC389174 (3q26.2),KCNMB3
A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2-q26.33.
Liu et al., Wuhan, China. In Hum Genet, 2008
Mutation analysis of KCNMB2 and KCNMB3, which were two potassium-channel genes in this linkage region, did not reveal a disease causing mutation.
Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.
Steinbach et al., Saint Louis, United States. In J Biol Chem, 2008
We have identified three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor.
Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits.
GeneRIF
Lingle et al., Saint Louis, United States. In J Gen Physiol, 2008
The KCNMB3 isoforms beta3a-d may have unique functions in primates.
Four-turn alpha-helical segment prevents surface expression of the auxiliary hbeta2 subunit of BK-type channel.
Ding et al., Wuhan, China. In J Biol Chem, 2008
The extracellular loop of hbeta2 acting as the channel regulator influences the rectification and toxin sensitivity of BK channels, and the inactivation domain at its N terminus induces rapid inactivation.
Expression of the human beta3 integrin subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and proliferation.
Clemmons et al., Chapel Hill, United States. In J Cell Physiol, 2008
In contrast, when human beta3 (hbeta3) was introduced into mSMC, there was an enhanced VN binding in spite of an equivalent amount of total beta3 expression, and IGF-I-dependent beta3, and SHPS-1 phosphorylation were detected.
Lysine-rich extracellular rings formed by hbeta2 subunits confer the outward rectification of BK channels.
Ding et al., Wuhan, China. In Plos One, 2007
Here we describe a functional element of the extracellular segment of hbeta2 auxiliary subunits that acts as the positively charged rings to modify the BK channel conductance.
Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.
Xu et al., Wuhan, China. In J Cell Physiol, 2007
The properties of native BK(i) currents obtained from both whole-cell and inside-out patches are very similar to inactivating BK channels produced by co-expressing mSlo1 alpha- and hbeta2-subunits in Xenopus oocytes.
Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel.
GeneRIF
Toro et al., Los Angeles, United States. In Neuroscience, 2007
reports that coexpression of beta2 subunit (KCNMB2) with hSlo can also modulate hSlo surface expression levels in HEK293T cells
BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism.
GeneRIF
Lingle et al., Saint Louis, United States. In J Neurosci, 2007
significance of inactivation in BK channels mediated by beta subunits arises not from inactivation, but from differences in the amplitude and duration of repolarizing currents arising from the beta-subunit-specific energetics of recovery from inactivation
Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy.
GeneRIF
Sander et al., Berlin, Germany. In Am J Med Genet B Neuropsychiatr Genet, 2007
The frequency of the delA750 mutation was significantly increased in idiopathic generalized epilepsy (7.9%) compared to that in the controls (5.5%; P = 0.016, one-sided; OR = 1.52; 95%-CI: 1.05-2.21).
Impact of rosiglitazone on the expression of beta3-AR in the stable cell lines expressed beta3-AR gene.
Liu et al., Changsha, China. In Clin Chem Lab Med, 2006
METHODS: We cloned the cDNA sequences of human PPAR-gamma2 (hPPAR-gamma2) gene and human wild type and mutant beta3-adrenergic receptor (hbeta3-AR) genes and established their eukaryotic expression vectors.
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