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Potassium large conductance calcium-activated channel, subfamily M, beta member 1

KCNMB1, H-beta, BKbeta1, hbeta1
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, OUT
Papers on KCNMB1
Regulation of gene expression by 17β-estradiol in the arcuate nucleus of the mouse through ERE-dependent and ERE-independent mechanisms.
Roepke et al., New Brunswick, United States. In Steroids, Feb 2016
Of note, Cacna1g and Kcnmb1 channel expression was increased by E2B in WT females only, suggesting an ERE-dependent regulation.
7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.
An et al., Pusan, South Korea. In Biochem Biophys Res Commun, Mar 2015
β1-Subunit of BKCa channel (KCNMB1; MaxiKβ1) has been reported as a modulator of vascular flexibility.
Solvent effects in acid-catalyzed biomass conversion reactions.
Dumesic et al., Madison, United States. In Angew Chem Int Ed Engl, 2014
This same behavior is displayed by strong solid Brønsted acid catalysts, such as H-mordenite and H-beta.
Mechanistic investigation of methanol to propene conversion catalyzed by H-beta zeolite: a two-layer ONIOM study.
Han et al., Shanghai, China. In J Mol Model, 2013
Two-layer ONIOM calculations have been carried out to study methanol to propene (MTP) conversion reactions catalyzed by H-beta zeolite.
Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent.
Dopico et al., Memphis, United States. In Mol Pharmacol, 2013
HENA failed to dilate the arteries from the KCNMB1 knockout mouse, underscoring BK β1's role in HENA action.
Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension.
Zeng et al., China. In Hypertension, 2013
and β1-subunit (KCNMB1) of BK(Ca) channels in isolated human vascular smooth muscle cells and mesenteric arteries from normotensive and hypertensive patients.
Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Lee et al., Rochester, United States. In Diabetes, 2012
these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
MOFs as multifunctional catalysts: one-pot synthesis of menthol from citronellal over a bifunctional MIL-101 catalyst.
Corma et al., Valencia, Spain. In Dalton Trans, 2012
The MOF was found to be stable under the reaction conditions used, and the results obtained indicate that the performance of this bifunctional solid catalyst is comparable with other state-of-the-art materials for the tandem reaction: Full citronellal conversion was attained over Pd@MIL-101 in 18 h, with 86% selectivity to menthols and a diastereoselectivity of 81% to the desired (-)-menthol, while up to 30 h were necessary for attaining similar values over Ir/H-beta under analogous reaction conditions.
Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice.
Fink et al., East Lansing, United States. In J Cardiovasc Pharmacol, 2012
Reduced vascular BK channel function does not protect against hypotension in the early stage of septic shock; in the later stage, smooth muscle BK channel deficiency enhances organ damage and mortality
Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells.
Cornfield et al., Stanford, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter
Conversion of isoprenoid oil by catalytic cracking and hydrocracking over nanoporous hybrid catalysts.
Asaoka et al., Kitakyūshū, Japan. In J Biomed Biotechnol, 2011
To evaluate the reaction scheme and products from model isoprenoid compounds of microalgae oil, nanoporous hybrid catalyst technologies (CC: ns Al₂O₃/H-USY and ns Al₂O₃/H-GaAlMFI; HC: [Ni-Mo/γ-Al₂O₃]/ns Al₂O₃/H-beta) were studied.
Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol.
Dopico et al., Memphis, United States. In Arterioscler Thromb Vasc Biol, 2011
Vascular smooth muscle cell cholesterol and BK beta1 are both required for ethanol inhibition of BK and resulting cerebral artery constriction, with health-related implications for manipulating cholesterol levels in alcohol-induced cerebrovascular disease.
Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
Prüss et al., Berlin, Germany. In Glia, 2011
BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells, to a lesser degree than BKbeta4 channels.
BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons.
Derst et al., Berlin, Germany. In Cell Mol Neurobiol, 2010
Immunocytochemical staining of rat hypothalamic neurons indicates strong BKbeta1 expression in the supraoptic nucleus and the magno- and parvocellular parts of the paraventricular nucleus.
Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease.
Köhler, Odense, Denmark. In Pflugers Arch, 2010
BKCa channel's ion-conducting alpha-subunit is encoded by the KCa1.1 gene, and the accessory and Ca2+-sensitivity modulating beta1-subunit is encoded by the KCNMB1 gene.
Beta-aminopeptidase-catalyzed biotransformations of beta(2)-dipeptides: kinetic resolution and enzymatic coupling.
Geueke et al., Dübendorf, Switzerland. In Chembiochem, 2010
BapA was shown to convert a diastereomeric mixture of the beta(2)-peptide H-beta(2)hPhe-beta(2)hAla-OH, but did not act on diastereomerically pure beta(2),beta(3)-dipeptides containing an N-terminal beta(2)-homoalanine.
Common charge-shift mutation Glu65Lys in K+ channel β₁-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease.
O'Connor et al., San Diego, United States. In Am J Nephrol, 2009
Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries.
BK channels in the kidney.
Sansom et al., Omaha, United States. In Curr Opin Nephrol Hypertens, 2007
ROMK-/- and wild-type mice on a high potassium diet exhibit BK-mediated potassium secretion, and studies of BK-alpha-/- and BK-beta1-/- mice suggest that flow-induced potassium secretion is mediated by BK-alpha/beta1, which is specifically localized in the apical membrane of the connecting tubule of the mouse and connecting tubule plus initial cortical collecting duct of the rabbit.
Neurofilaments in health and disease.
Gotow, Takarazuka, Japan. In Med Electron Microsc, 1999
Transgenic mice expressing NF-H-beta-galactosidase protein also showed NF accumulation in the perikarya, which was similar in organization and NF-H phosphorylation to that in aluminum-treated rabbits, but NFs were almost absent from the axonal compartment in these mice that did not show any overt phenotype.
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