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Potassium channel, subfamily K, member 7

KCNK7, two pore domain K+ channel
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TREK-1, ACID, TWIK-1, TASK-2, TRAAK
Papers on KCNK7
Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.
Lesage et al., Antibes, France. In Pflugers Arch, May 2015
Other silent channels KCNK7, TWIK2, and TASK5 are still under study.
Presence of task-1 channel in the laryngeal mucosa in the newborn lamb.
Praud et al., Sherbrooke, Canada. In Exp Lung Res, 2011
Of these are found several members of the 4-transmembrane domain, 2-pore K(+) channel family (K2P family), namely Twik-1 and -2, Trek-1 and -2, Task-2, -3, and -4, Thik-1, and KCNK7.
Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.
Sonner et al., San Francisco, United States. In Behav Brain Res, 2008
In this study we tested whether inactivation of another member of this ion channel family, KCNK7, in a knockout mouse displayed altered sensitivity to the anesthetizing effect of volatile anesthetics.
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.
Pangalos et al., Harlow, United Kingdom. In Brain Res Mol Brain Res, 2001
TWIK-1 and the TWIK-1-like channel KCNK7 were predominantly expressed in the CNS, in contrast to TWIK-2 which was preferentially expressed in peripheral tissues such as pancreas, stomach, spleen and uterus.
TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons.
Bayliss et al., Charlottesville, United States. In Neuron, 2000
We show that TASK-1, a two pore domain K+ channel, provides a prominent leak K+ current and target for neurotransmitter modulation in hypoglossal motoneurons (HMs).
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.
Lazdunski et al., Antibes, France. In J Biol Chem, 1999
A closely related human KCNK7-A subunit has been cloned.
Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.
Lazdunski et al., Antibes, France. In J Biol Chem, 1998
A complementary DNA encoding a novel K+ channel, called TASK-2, was isolated from human kidney and its gene was mapped to chromosome 6p21.
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