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Potassium voltage-gated channel, Isk-related family, member 4

KCNE4
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KCNE1, KCNQ1, CAN, Kv1.4, ACID
Papers on KCNE4
Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice.
New
Abbott et al., Irvine, United States. In Faseb J, Jan 2016
Here, we show that the transcript for KCNE4, a voltage-gated potassium (Kv) channel β subunit associated with human atrial fibrillation, was 8-fold more highly expressed in the male left ventricle compared with females in young adult C57BL/6 mice (P < 0.05).
Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone.
New
Greenwood et al., Copenhagen, Denmark. In J Physiol, Jan 2016
KEY POINTS: KCNE4 alters the biophysical properties and cellular localization of voltage-gated potassium channel Kv7.4.
Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
Bocksteins et al., Copenhagen, Denmark. In Sci Rep, 2014
current extensively, whereas KCNE2 and KCNE4 only exert minor effects.
The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues.
Bogoyevitch et al., Melbourne, Australia. In Biochem Biophys Res Commun, 2014
ΔN JNK3α1), and interaction evaluation in the yeast two-hybrid system defined the interacting partners as either JNK1-specific interactors (ATF7, FUS, KCNE4, PIAS1, SHANK1, TKT), typical JBD-dependent interactors shared by JNK1α1 and JNK3α1 (AKAP6, BMPR2, EEF1A1, GFAP, GRIP2, GTF2F1, HDAC2, MAP1B, MYO9B, PTPN2, RABGAP1, RUSC2, SUMO1, SYPL1, TOPBP1, ZNF668), or JNK3-specific partners (ATXN1, NNAT, PTGDS) dependent on interaction with the JNK3 N-terminal extension.
[Association of single nucleotide polymorphism of KCNE1 and KCNE4 gene with atrial fibrillation in Xinjiang Uygur and Han population].
Tang et al., Ürümqi, China. In Zhonghua Xin Xue Guan Bing Za Zhi, 2013
OBJECTIVE: To investigate the association between the KCNE1 gene G38S and the KCNE4 gene E145D and atrial fibrillation in Uygur and Han populations living in Xinjiang.
KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium.
Hughes et al., In Exp Eye Res, 2013
Among the five members of the KCNE gene family, transcripts for KCNE1, KCNE2, KCNE3, and KCNE4 were detected in bovine RPE, but only KCNE1 and KCNE2 proteins were detected.
KCNQ and KCNE Potassium Channel Subunit Expression in Bovine Retinal Pigment Epithelium.
Hughes et al., Ann Arbor, United States. In Exp Eye Res, 2013
Among the five members of the KCNE gene family, transcripts for KCNE1, KCNE2, KCNE3, and KCNE4 were detected in bovine RPE, but only KCNE1 and KCNE2 proteins were detected.
[Effect of additional disease (comorbidity) on association of allergic rhinitis with KCNE4 gene rs12621643 variant].
Puzyrev et al., In Genetika, 2013
Analysis of association of allergic rhinitis with the KCNE4 gene rs12621643 variant was conducted in Russian residents of Western Siberia (taking into account comorbidity with bronchial asthma).
Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease.
Chandy et al., Irvine, United States. In J Biol Chem, 2013
The topological similarity of MMP23-PD to KCNE1, KCNE2, and KCNE4 proteins that trap KV1.3, KV1.4,
[Genome-wide association study of allergic diseases in Russians of Western Siberia].
Puzyrev et al., In Mol Biol (mosk), 2011
Genes located in the loci, YWHAB and PPP1R12B for asthma and KCNE4 for allergic rhinitis, are new genes for these diseases.
KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.
GeneRIF
George et al., Nashville, United States. In J Biol Chem, 2011
KCNE4 juxtamembrane region is required for interaction with calmodulin and for functional suppression of KCNQ1.
The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study.
Christiansen et al., Copenhagen, Denmark. In J Negat Results Biomed, 2010
RESULTS: The coding regions of KCNE1, KCNE2, KCNE3, KCNE4, and KCNE5 were examined, by direct DNA sequencing, in a cohort of 93 unrelated HCM probands and 188 blood donor controls.Fifteen genetic variants, four previously unknown, were identified in the HCM probands.
The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.
GeneRIF
Goldstein et al., Chicago, United States. In J Physiol, 2010
MiRP3 modulates Kv4.2 current activation, inactivation and recovery from inactivation. MiRP3 shifts the half-maximal voltage for activation and slows time to peak ~ 100%.
Does a physiological role for KCNE subunits exist in the immune system?
Felipe et al., Barcelona, Spain. In Commun Integr Biol, 2010
We have described for the first time a molecular interaction between KCNE4 and the voltage-dependent potassium channel K(V)1.3.
KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating.
GeneRIF
Felipe et al., Barcelona, Spain. In J Cell Sci, 2009
KCNE4 (potassium voltage-gated channel subfamily E member 4), but not KCNE2, functions as an inhibitory Kv1.3 partner in leukocytes.
KCNE4 domains required for inhibition of KCNQ1.
GeneRIF
George et al., Nashville, United States. In J Physiol, 2009
Specific KCNE4 domains responsible for the inhibitory effects on heterologously expressed KCNQ1 were identified. The KCNE4 C-terminus is critical for KCNQ1 modulation and physically interacts with KCNQ1.
MiRP3 acts as an accessory subunit with the BK potassium channel.
GeneRIF
Goldstein et al., Chicago, United States. In Am J Physiol Renal Physiol, 2008
MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion.
[Thyrotoxic hypokalemic periodic paralysis, an endocrine emergency: clinical and genetic features in 25 patients].
Review
Maciel et al., São Paulo, Brazil. In Arq Bras Endocrinol Metabol, 2004
We identified the mutation R83H in the KCNE3 gene in one sporadic case, and M58V in the KCNE4 gene in one case with family history.
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