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Potassium voltage-gated channel, shaker-related subfamily, member 10

KCNA10, Kcn1
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Kv1.3, ROMK, Kvbeta1, KH1
Papers on KCNA10
Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka.
Koizumi et al., Sydney, Australia. In Environ Health Prev Med, Sep 2015
RESULTS: Association study revealed rs34970857 (c.658G > A/p.V220M) located in the KCNA10 gene encoding a voltage-gated K channel as the most promising SNP with the highest odds ratio of 1.74.
A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction.
Morell et al., Rockville, United States. In Hear Res, 2013
KCNA10 is a voltage gated potassium channel that is expressed in the inner ear.
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
Yuan et al., San Diego, United States. In Am J Physiol Lung Cell Mol Physiol, 2006
BMP-2 (100 nM for 18-24 h) significantly (>2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2.
Renal potassium channels: recent developments.
Wang, Valhalla, United States. In Curr Opin Nephrol Hypertens, 2004
RECENT FINDINGS: Several types of voltage-gated K+ (Kv) channel, such as KCNQ1, KCNA10 and Kv1.3, are highly expressed at the apical membrane of proximal tubules and distal tubules.
Molecular cloning and partial functional characterization of Tsha3--a novel modulatory potassium channel alpha-subunit of trout CNS.
Jeserich et al., Osnabrück, Germany. In Brain Res Mol Brain Res, 2004
A novel Shaker-related potassium channel subunit termed Tsha3 that is widely expressed in the CNS of trout was PCR-cloned and sequenced: its deduced amino acid sequence showed an extended N-terminal domain with a high proportion of negatively charged residues and possessed highest similarity with KCNA10, a human epithelial potassium channel.
Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule.
Desir et al., New Haven, United States. In J Am Soc Nephrol, 2002
KCNA10 in human proximal tubular cells, glomerular and vascular endothelial cells, and also in vascular smooth muscle cells.
Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit.
Desir et al., New Haven, United States. In Am J Physiol Renal Physiol, 2002
The aim of the present study was to isolate accessory proteins for KCNA10, a novel Kv channel alpha-subunit functionally related to Kv and cyclic nucleotide-gated cation channels.
Genetic variations in five genes involved in the excitement of cardiomyocytes.
Tanaka et al., Tokyo, Japan. In J Hum Genet, 2000
We provide here 29 genetic variations, including 28 novel ones, in five genes that are potentially involved in the excitement of cardiomyocytes: we found 4 in KCNA10, 2 in KCNK1, 8 in KCNK6, 11 in SLC18A1 (VMAT1), and 4 in SLC6A2 (norepinephrine transporter).
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.
Desir et al., Burlington, United States. In Am J Physiol Renal Physiol, 2000
Because Kcn1 did not express well (peak current in Xenopus laevis oocytes of 0.3 microA at +60 mV), the human homolog (KCNA10) was isolated, and its expression was optimized in oocytes.
Genomic localization of the human gene for KCNA10, a cGMP-activated K channel.
Desir et al., New Haven, United States. In Genomics, 1997
KCNA10 represents a new class of K channel specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP.
Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel.
Desir et al., New Haven, United States. In Am J Physiol, 1996
We recently cloned a novel rabbit gene that encodes a 725-amino acid protein (Kcn1) (Y.
Primary structure and functional expression of a cGMP-gated potassium channel.
Desir et al., New Haven, United States. In Proc Natl Acad Sci U S A, 1996
Herein we report the isolation from rabbit of a gene encoding a K channel (Kcn1) that is specifically activated by cGMP and not by cAMP.
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