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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 12, member 7

Top mentioned proteins: KCC3, ACID, HAD, V1a, CAN
Papers on KCC4
DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma.
Carling et al., New Haven, United States. In Surgery, Jan 2016
BACKGROUND: Overexpression of Solute carrier family 12 member 7 (SLC12A7) promotes tumor aggressiveness in various cancers.
Expression of GABA receptors subunits in peripheral blood mononuclear cells is gender dependent, altered in pregnancy and modified by mental health.
Birnir et al., Uppsala, Sweden. In Acta Physiol (oxf), Mar 2015
The GABA-B1 receptor was up-regulated by depression in pregnant women, while the transporters NKCC1 and KCC4 were down-regulated by pregnancy.
Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume.
Fowke et al., Nashville, United States. In Plos One, 2014
Other noteworthy SNPs that were nominally associated (p-value < 1x10(-4)) with log-PV included rs9583484 (intronic SNP in COL4A2), rs10146527 (intronic SNP in NRXN3), rs9909466 (SNP near RPL32P31), and rs2241606 (synonymous SNP in SLC12A7).
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.
Zhang et al., Dundee, United Kingdom. In Biochem J, 2014
We also observe that KCCs are directly phosphorylated by SPAK/OSR1, at a novel Site-3 (Thr5 in KCC1/KCC3 and Thr6 in KCC2/KCC4), and a previously recognized KCC3-specific residue, Site-4 (Ser96).
[Pathophysiological aspects of K+: Cl- cotransporters].
Melo et al., Nueva San Salvador, El Salvador. In Rev Invest Clin, 2014
Among them are two loop diuretics-sensitive Na+:K+:2Clcotransporters (NKCC1/NKCC2), the thiazide-sensitive Na+:Cl- cotransporter (NCC), and finally the K+:Cl- cotransporters (KCC), encoded for at least four homologous genes (KCC1-KCC4), and from which there are many isoforms due to alternative splicing.
Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
Joiner et al., Los Angeles, United States. In Am J Hematol, 2014
Both VEGF and PlGF treatment of human erythroid K562 cells increased both mRNA and protein levels of KCC1, KCC3b, and KCC4.
Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Gamba et al., Mexico. In Am J Physiol Renal Physiol, 2013
K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated cells of the collecting duct.
Glycosylation regulates the function and membrane localization of KCC4.
Chou et al., Tainan City, Taiwan. In Biochim Biophys Acta, 2013
However, the importance of glycosylation for KCC4 function has not previously been demonstrated.
K+-Cl- cotransporter-2 KCC2 in chicken cardiomyocytes.
Payne et al., Davis, United States. In Am J Physiol Cell Physiol, 2013
In silico analysis showed that while exon 22 of KCC2 is unique to this isoform in therian mammals, it is retained in KCC2's closest paralog, KCC4, of lower vertebrates, including chicken.
A molecular analysis of the Na(+)-independent cation chloride cotransporters.
Di Fulvio et al., Saskatoon, Canada. In Cell Physiol Biochem, 2012
In this review, we will look at the exceptionally large variety of potential splice variants within the Na(+)-independent cation-chloride cotransporter (SLC12A4-SLC12A7) genes, their initial tissue identification, and their physiological relevance.
cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium.
Marcus et al., Manhattan, United States. In Bmc Physiol, 2012
Expression of transcripts for CFTR; for KCC1, KCC3a, KCC3b and KCC4, but not KCC2; for NKCC1 but not NKCC2 and for WNK1 but only very low WNK4 was determined.
K-Cl cotransporter gene expression during human and murine erythroid differentiation.
Joiner et al., Cincinnati, United States. In J Biol Chem, 2011
KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity
Similar effects of all WNK3 variants on SLC12 cotransporters.
Mercado et al., Mexico. In Am J Physiol Cell Physiol, 2011
The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
Frog oocytes to unveil the structure and supramolecular organization of human transport proteins.
Fotiadis et al., Bern, Switzerland. In Plos One, 2010
Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.
WNK3 is a putative chloride-sensing kinase.
Gamba et al., Mexico. In Cell Physiol Biochem, 2010
Using the Xenopus laevis oocyte heterologous expression system, it has been shown that WNK3 activates the Na(+)-coupled chloride cotransporters NKCC1, NKCC2, and NCC and inhibits the K(+)-coupled chloride cotransporters KCC1 through KCC4.
Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.
Sakai et al., Toyama, Japan. In Biol Pharm Bull, 2010
Recent our studies have demonstrated that K⁺-Cl⁻ cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells.
Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.
Nothwang et al., Oldenburg, Germany. In J Biol Chem, 2010
analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4
A mathematical model of rat ascending Henle limb. I. Cotransporter function.
Weinstein, In Am J Physiol Renal Physiol, 2010
Kinetic models of Na+-K+-2Cl- costransporter (NKCC2) and K+-Cl- cotransporter (KCC4), two of the key cotransporters of the Henle limb, are fashioned with inclusion of terms representing binding and transport of NH4+.
Functional significance of channels and transporters expressed in the inner ear and kidney.
Wangemann et al., Tübingen, Germany. In Am J Physiol Cell Physiol, 2007
Defective connexins (GJB2 and GJB6), pendrin (SLC26A4), K(+) channels (KCNJ10, KCNQ1, KCNE1, and KCNMA1), Na(+)-2Cl(-)-K(+) cotransporter (SLC12A2), K(+)/Cl(-) cotransporters (KCC3 and KCC4), Cl(-) channels (BSND and CLCNKA + CLCNKB), and H(+)-ATPase (ATP6V1B1 and ATPV0A4) cause hearing loss.
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Jentsch et al., Hamburg, Germany. In Nature, 2002
Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown.
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