SPAK mediates KCC3-enhanced cervical cancer tumorigenesis.
Tainan City, Taiwan. In Febs J, May 2014
Ste20-related proline/alanine-rich kinase (SPAK) plays a role in regulating many biological activities, and interacts with K-Cl co-transporter 3 (KCC3); however, the importance of SPAK for KCC3 function has not been demonstrated.
[Pathophysiological aspects of K+: Cl- cotransporters].
Nueva San Salvador, El Salvador. In Rev Invest Clin, Mar 2014
KCCs belong to the SLC12 (Solute Carrier Family 12) family of electroneutral cation-chloride cotransporters (CCC), and they are secondary active ion transporters because use the established gradients from the primary active transporter through the Na+/K+- ATPase.
Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Mexico. In Am J Physiol Renal Physiol, 2013
K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated cells of the collecting duct.
Functional significance of channels and transporters expressed in the inner ear and kidney.
Tübingen, Germany. In Am J Physiol Cell Physiol, 2007
Defective connexins (GJB2 and GJB6), pendrin (SLC26A4), K(+) channels (KCNJ10, KCNQ1, KCNE1, and KCNMA1), Na(+)-2Cl(-)-K(+) cotransporter (SLC12A2), K(+)/Cl(-) cotransporters (KCC3 and KCC4), Cl(-) channels (BSND and CLCNKA + CLCNKB), and H(+)-ATPase (ATP6V1B1 and ATPV0A4) cause hearing loss.
Molecular genetics of bipolar disorder and depression.
Wako, Japan. In Psychiatry Clin Neurosci, 2007
Several candidate genes for schizophrenia may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6.