K-Cl cotransporters, cell volume homeostasis, and neurological disease.
Boston, United States. In Trends Mol Med, 01 Aug 2015
Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich kinase (SPAK) serine-threonine kinases, have demonstrated the evolutionary necessity of these molecules for nervous system cell volume regulation, structure, and function, and their involvement in neurological disease.
SPAK mediates KCC3-enhanced cervical cancer tumorigenesis.
Tainan City, Taiwan. In Febs J, May 2014
Ste20-related proline/alanine-rich kinase (SPAK) plays a role in regulating many biological activities, and interacts with K-Cl co-transporter 3 (KCC3); however, the importance of SPAK for KCC3 function has not been demonstrated.
[Pathophysiological aspects of K+: Cl- cotransporters].
Nueva San Salvador, El Salvador. In Rev Invest Clin, Mar 2014
KCCs belong to the SLC12 (Solute Carrier Family 12) family of electroneutral cation-chloride cotransporters (CCC), and they are secondary active ion transporters because use the established gradients from the primary active transporter through the Na+/K+- ATPase.
Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Mexico. In Am J Physiol Renal Physiol, 2013
K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated cells of the collecting duct.