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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Histone acetyltransferase 1

KAT1, HAT1, glutamine transaminase K
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: ACID, Histone, CAN, HAD, H4
Papers on KAT1
Oint genetic and network analyses identify loci associated with root growth under NaCl stress in Arabidopsis thaliana.
New
Koyama et al., Gifu, Japan. In Plant Cell Environ, Jan 2016
Several known salinity tolerance genes such as potassium channel KAT1 and calcium sensor SOS3 were also linked to SNPs in the top 200.
In vitro maturation affects chromosome segregation, spindle morphology and acetylation of lysine 16 on histone H4 in horse oocytes.
New
Luciano et al., In Reprod Fertil Dev, Jan 2016
Experiments were conducted to compare: (1) the incidence of aneuploidy, (2) the morphology of the spindle, (3) the acetylation of lysine 16 on histone H4 (H4K16) and (4) the relative amount of histone acetyltransferase 1 (HAT1), K(lysine) acetyltransferase 8 (KAT8, also known as MYST1), histone deacetylase 1 (HDAC1) and NAD-dependent protein deacetylase sirtuin 1 (SIRT1) mRNA in metaphase II stage oocytes that were in vitro matured or collected from peri-ovulatory follicles.
MiR-486 Regulates Cholesterol Efflux by Targeting HAT1.
New
Tang et al., Hengyang, China. In Biochem Biophys Res Commun, Jan 2016
METHODS AND RESULTS: Based on bioinformatics analysis and luciferase reporter assay, we transfected miR-486 mimic and miR-486 inhibitor into THP-1 macrophage-derived foam cells, and found that miR-486 directly bound to histone acetyltransferase-1 (HAT1) 3'UTR, and downregulated its mRNA and protein expression.
A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
New
Lusser et al., Innsbruck, Austria. In Nucleic Acids Res, Dec 2015
Notably, we identified a novel complex consisting of the histone acetyltransferase Hat1, Caf1 and CENP-A/H4.
CmWRKY15 Facilitates Alternaria tenuissima Infection of Chrysanthemum.
Chen et al., Nanjing, China. In Plos One, 2014
NCED3A, NCED3B, GTG1, AKT1, AKT2, KAT1, KAT2, and KC1were compared between transgenic plants and controls.
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening.
Xie et al., Shanghai, China. In Cell Biosci, 2014
RESULTS: Depletion of KAT8 or HAT1 via RNA interference (RNAi) markedly down-regulated HBV-DNA and pgRNA levels in HepG2.2.15 cells, with KAT8 knockdown reducing both HBsAg and HBeAg more than HAT1 knockdown.
Histone acetyltransferase 1: more than just an enzyme?
Review
Parthun, Columbus, United States. In Biochim Biophys Acta, 2013
Histone acetyltransferase 1 (HAT1) is an enzyme that is likely to be responsible for the acetylation that occurs on lysines 5 and 12 of the NH2-terminal tail of newly synthesized histone H4.
Ion channels in plants.
Review
Impact
Hedrich, Würzburg, Germany. In Physiol Rev, 2012
Interestingly, one of the first identified potassium-channel genes encoding the Shaker-type channel KAT1 was shown to be highly expressed in guard cells.
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
GeneRIF
Puglielli et al., Madison, United States. In J Biol Chem, 2012
IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1
Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4.
GeneRIF
Zhang et al., Rochester, United States. In J Biol Chem, 2012
HAT1 differentially impacts nucleosome assembly of H3.1-H4 and H3.3-H4.
The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids.
GeneRIF
Dreyer et al., Talca, Chile. In Biochem J, 2012
instead of single key amino acids, several titratable residues contribute to the pH-sensor of the plant Kin channel KAT1
Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin.
GeneRIF
Gärtner et al., Göttingen, Germany. In Am J Hum Genet, 2012
Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1.
New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine γ-lyase.
GeneRIF
Cooper et al., Macon, United States. In Arch Biochem Biophys, 2012
CH(3)Hg-S-Cys and Cys-S-Hg-S-Cys are substrates and reversible inhibitors of GTK.
SnRK2 protein kinases--key regulators of plant response to abiotic stresses.
Review
Dobrowolska et al., Warsaw, Poland. In Omics, 2011
The regulation of the plant response to ABA via SnRK2s pathways occurs by direct phosphorylation of various downstream targets, for example, SLAC1, KAT1, AtRbohF, and transcription factors required for the expression of numerous stress response genes.
Abscisic acid signal off the STARting block.
Review
Leung et al., Gif-sur-Yvette, France. In Mol Plant, 2011
thus unleashing the pathway by freeing them to phosphorylate downstream targets that now include several b-ZIP transcription factors, ion channels (SLAC1, KAT1), and a NADPH oxidase (AtrbohF).
A brand new START: abscisic acid perception and transduction in the guard cell.
Review
Leung et al., Gif-sur-Yvette, France. In Sci Signal, 2010
In guard cells, a specific SnRK2, OPEN STOMATA 1 (OST), stimulates H(2)O(2) production by NADPH oxidase respiratory burst oxidase protein F and inhibits potassium ion influx by the inward-rectifying channel KAT1.
Structure prediction for the down state of a potassium channel voltage sensor.
Impact
GeneRIF
Jan et al., In Nature, 2007
Structure prediction for the down state of the Kat1 voltage sensor
Endocytotic cycling of PM proteins.
Review
Impact
Peer et al., West Lafayette, United States. In Annu Rev Plant Biol, 2004
Recent evidence of plasma membrane cycling of members of the PIN auxin efflux facilitator family and the KAT1 inwardly rectifying potassium channel demonstrates that endocytotic cycling of some form occurs in plants.
Structural basis for modulation and agonist specificity of HCN pacemaker channels.
Impact
Gouaux et al., Seattle, United States. In Nature, 2003
On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism.
Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA.
Impact
Gaber et al., San Diego, United States. In Science, 1993
This report shows that a single messenger RNA transcript from the Arabidopsis thaliana KAT1 complementary DNA confers the functional expression of a hyperpolarization-activated K+ channel in Xenopus oocytes.
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