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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Opioid receptor, kappa 1

kappa-opioid receptor, KOR, a kappa-opioid receptor
Top mentioned proteins: mu-opioid receptor, CAN, HAD, V1a, ACID
Papers using kappa-opioid receptor antibodies
Green fluorescent protein as a marker for gene expression
Okano Hideyuki et al., In Molecular Brain, 1993
... The numerical data for the KOr spectra were obtained at ...
Papers on kappa-opioid receptor
Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests.
Liu-Chen et al., Philadelphia, United States. In Neurosci Lett, Feb 2016
UNASSIGNED: Prototypical long-acting kappa opioid receptor (KOPR) antagonists [e.g., norbinaltorphimine (norBNI)] have been reported to exert anxiolytic-like effects in several commonly used anxiety tests in rodents including the novelty-induced hypophagia (NIH) and elevated plus maze (EPM) tests.
Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues.
Wiemer et al., In J Org Chem, Feb 2016
UNASSIGNED: Pawhuskin A is a prenylated stilbene that functions as an antagonist of the kappa opioid receptor.
Electroacupuncture relieves labour pain and influences the spinal dynorphin/κ-opioid receptor system in rats.
Feng et al., Nanning, China. In Acupunct Med, Feb 2016
BACKGROUND: The dynorphin (DYN)/κ-opioid receptor (KOR) system plays a key role in the control of labour pain.
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
Janecka et al., Łódź, Poland. In Eur J Med Chem, Jan 2016
The data obtained here showed that only cyclopeptides modified in position 4 retained the sub-nanomolar MOR and nanomolar κ-opioid receptor (KOR) affinity, similar but not better than that of a parent cyclopeptide.
Biased agonism at kappa opioid receptors: Implication in pain and mood disorders.
Yadav et al., Lucknow, India. In Eur J Pharmacol, Oct 2015
The kappa opioid receptor (k receptor) and its endogenous ligand dynorphin have received significant attention due to their involvement in pathophysiology of mood disorders, drug addiction, psychotic disorders and pain.
[Anti-inflammatory and synovial-opioid system effects of electroacupuncture intervention on chronic pain in arthritic rats].
Fang et al., In Zhongguo Zhen Jiu, Sep 2015
The levels of beta-endorphin (β-END), met-enkephalin (met-ENK), dynorphin A (Dyn A) were measured by radioimmunoassay; the mRNA expressions of mu opioid receptor (MOR), kappa opioid receptor (KOR) and delta opioid receptor (DOR) in synovial tissues of CIA rats were detected by I quantitative polymerase chain reaction (qPCR).
Nalbuphine, a non-controlled opioid analgesic, and its potential use in research mice.
Narver, Bethesda, United States. In Lab Anim (ny), Mar 2015
A kappa opioid receptor agonist and mu opioid receptor antagonist, nalbuphine causes fewer adverse effects than other opioid analgesics.
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.
Kreek et al., New York City, United States. In Front Pharmacol, 2014
Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the dynorphins) in higher functions, including cognition and perceptual effects.
Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi.
Gao et al., China. In Curr Med Chem, 2014
These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties.
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction.
Mavrikaki et al., Belmont, United States. In Front Neurosci, 2014
KOR agonists produce signs of anxiety, fear, and depression in laboratory animals and humans, findings that have led to the hypothesis that drug withdrawal-induced DYN release is instrumental in negative reinforcement processes that drive addiction.
Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
Chavkin et al., Seattle, United States. In J Neurosci, 2012
Repeated stress exposure reduces KOR inhibitory regulation on 5-serotonin (HT)neuronal excitability postsynaptically.
Centrally administered apelin-13 induces depression-like behavior in mice.
Chen et al., Lanzhou, China. In Brain Res Bull, 2012
Centrally administered apelin-13 elicited depression-like behavior in mice, which was mediated via APJ receptor and kappa-opioid receptor, but not CRF receptor.
Dynorphins regulate fear memory: from mice to men.
Zimmer et al., Bonn, Germany. In J Neurosci, 2012
A role is estsablished for dynorphin kappa-opioid receptor signaling in fear extinction.
Structure of the human κ-opioid receptor in complex with JDTic.
Stevens et al., Los Angeles, United States. In Nature, 2012
crystal structure of the human kappa-OR in complex with the selective antagonist JDTic, arranged in parallel dimers, at 2.9 A resolution
IFN-γ up-regulates κ opioid receptors (KOR) on murine macrophage cell line J774.
Brozovic et al., Zagreb, Croatia. In J Neuroimmunol, 2012
Macrophages express kappa opioid receptors, which signal via ERK1/2 phosphorylation and which are upregulated by proinflammatory IFN-gamma.
Transcriptional and epigenetic regulation of opioid receptor genes: present and future.
Loh et al., Minneapolis, United States. In Annu Rev Pharmacol Toxicol, 2010
Regulation of KOR expression is distinctly complex, and KOR exerts a unique function in neurite extension, indicating that KOR is not simply a pharmacological cousin of MOR and DOR.
Sitosterol-beta-glucoside as primer for cellulose synthesis in plants.
Delmer et al., Davis, United States. In Science, 2002
The cellulase encoded by the Korrigan (Kor) gene, required for cellulose synthesis in plants, may function to cleave SG from the growing polymer chain.
Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor.
Fields et al., San Francisco, United States. In Nature, 1997
The analgesic effect of clinically used exogenous opioids, such as morphine, is mediated primarily through mu-opioid receptors, but the function of the kappa-receptor in opioid analgesia is unclear.
The molecular basis of opioid receptor function.
Simonds, Bethesda, United States. In Endocr Rev, 1988
The kappa-opioid receptor from guinea pig brain exhibits a unique mobility on sucrose density gradient centrifugation but has not been characterized in purified form.
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
Goldstein et al., In Science, 1982
In the two preparations studied, the dynorphin receptor appears to be the same as the kappa opioid receptor.
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