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Zinc finger and BTB domain containing 33

Kaiso, xKaiso
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-?2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: CAN, V1a, E-cadherin, Armadillo, Rhodopsin
Papers on Kaiso
Knockout Zbtb33 gene results in an increased locomotion, exploration and pre-pulse inhibition in mice.
Prokhortchouk et al., Novosibirsk, Russia. In Behav Brain Res, Feb 2016
The Zbtb33 gene encodes the Kaiso protein-a bimodal transcriptional repressor.
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.
Yates et al., United States. In Oncotarget, Jan 2016
UNASSIGNED: Kaiso, a member of the BTB/POZ zinc finger protein family, functions as a transcriptional repressor by binding to sequence-specific Kaiso binding sites or to methyl-CpG dinucleotides.
MTSS1 is a critical epigenetically regulated tumor suppressor in CML.
Koschmieder et al., Aachen, Germany. In Leukemia, Jan 2016
CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors.
Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.
Daniel et al., Hamilton, Canada. In Biochim Biophys Acta, Dec 2015
Interestingly, Kaiso's regulation of HIF1A occurs primarily during hypoxia, which is consistent with the finding that Kaiso protein levels peak after 4 h of hypoxic incubation and return to normoxic levels after 24 h.
Kaiso represses the expression of glucocorticoid receptor via a methylation-dependent mechanism and attenuates anti-apoptotic activity of glucocorticoids in breast cancer cells.
Hu et al., Changsha, China. In Bmb Rep, Nov 2015
UNASSIGNED: Kaiso is a Pox Virus and Zinc Finger (POZ-ZF) transcription factor with bi-modal DNA-binding specificity.
Transcriptional activation of APAF1 by KAISO (ZBTB33) and p53 is attenuated by RelA/p65.
Hur et al., Seoul, South Korea. In Biochim Biophys Acta, Sep 2015
KAISO, a member of the POK protein family, is induced by DNA-damaging agents to enhance apoptosis in a p53-dependent manner.
Engineering of Human Corneal Endothelial Grafts.
Tseng et al., Miami, United States. In Curr Ophthalmol Rep, Sep 2015
Herein, we summarize our novel approach in engineering HCEC grafts based on selective activation of p120-Kaiso signaling that is coordinated with activation of Rho-ROCK-canonical BMP signaling to reprogram HCEC into neural crest progenitors.
p120-catenin in cancer - mechanisms, models and opportunities for intervention.
Derksen et al., Utrecht, Netherlands. In J Cell Sci, 2013
In this setting, p120 translocates to the cytosol where it exerts oncogenic properties through aberrant regulation of Rho GTPases, growth factor receptor signaling and derepression of Kaiso (also known as ZBTB33) target genes.
On how mammalian transcription factors recognize methylated DNA.
Defossez et al., Salt Lake City, United States. In Epigenetics, 2013
The last piece of the puzzle has been recently revealed by the structural resolution of two different zinc finger proteins, Kaiso and ZFP57, in complex with methylated DNA.
p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.
Anastasiadis et al., Jacksonville, United States. In Prog Mol Biol Transl Sci, 2012
Nuclear signaling is affected by the interaction of p120 with Kaiso, a transcription factor regulating Wnt-responsive genes as well as transcriptionally repressing methylated promoters.
Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO.
Deplancke et al., Lausanne, Switzerland. In Mol Cell, 2012
KAISO, similar to SMRT, accelerates the cell cycle and increases fat accumulation upon knockdown, identifying KAISO as an adipogenic repressor that likely modulates the mitotic clonal expansion phase of this process.
The role of methyl-binding proteins in chromatin organization and epigenome maintenance.
Defossez et al., Paris, France. In Brief Funct Genomics, 2012
Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-binding proteins (MBPs), which belong to three different structural families in mammals: the MBD family, the Kaiso and Kaiso-like proteins and the SRA domain proteins.
Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl-CpG DNA targets.
Wright et al., Los Angeles, United States. In Febs Lett, 2012
Data show that Kaiso requires all three zinc fingers plus adjacent protein regions for DNA recognition.
Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway.
McCrea et al., Houston, United States. In J Cell Sci, 2012
Dyrk1A positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (and canonical Wnt) gene targets such as siamois and wnt11.
P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
Wang et al., Shenyang, China. In Plos One, 2011
Results suggest that p120ctn isoforms 1 and 3 up-regulate cyclin D1, and thereby cyclin E, resulting in the promotion of cell proliferation and cell cycle progression in lung cancer cells.
Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition.
Tseng et al., Miami, United States. In Plos One, 2011
Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition.
Biological functions of methyl-CpG-binding proteins.
Stancheva et al., Paris, France. In Prog Mol Biol Transl Sci, 2010
In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins.
A role for Kaiso-p120ctn complexes in cancer?
McCrea et al., Gent, Belgium. In Nat Rev Cancer, 2005
Kaiso belongs to the zinc finger and broad-complex, tramtrack and bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein family that has been implicated in tumorigenesis.
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin.
McCrea et al., Houston, United States. In Nat Cell Biol, 2004
p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.
RImmunohistochemical Evaluation of E-cadherin/catenin (alpha-, beta-, gamma-catenin and p120CTN) Complex Expression in Early Gastric Cancer.
Suh et al., In Cancer Res Treat, 2003
Nuclear staining of the beta-catenin was observed in 5 (10.6%) cases, but nuclear staining of the p120CTN, a promotor of Kaiso transcriptional factor, was not seen.
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