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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD82 molecule

KAI1, CD82, C33
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tetraspanin, CD81, CAN, HAD, CD63
Papers on KAI1
Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37.
New
Wright et al., Melbourne, Australia. In J Immunol, Feb 2016
UNASSIGNED: This study supports a new concept where the opposing functions of the tetraspanins CD37 and CD82 may coordinate changes in migration and Ag presentation during dendritic cell (DC) activation.
Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors.
New
Gu et al., Shanghai, China. In Oncol Rep, Jan 2016
Sulf2 upregulated c-fos induced growth factor (FIGF) and nuclear receptor subfamily 4 group A member 3 (NR4A3) expression and downregulated the cluster of differentiation 82 (CD82) and platelet-derived growth factor C (PDGFC) expression in breast cancer.
[Expressions of Snail, Slug and KAI1 proteins in cervical carcinoma and their clinicopathological significance].
New
Cheng et al., Bengbu, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jan 2016
OBJECTIVE: To explore the expression of Snail and Slug in primary cervical squamous cell carcinoma (CSCC) and their relationship with KAI1 expression.
GM3 and cancer.
Review
New
Handa et al., Seattle, United States. In Glycoconj J, Feb 2015
GM3 is highly enriched in a type of membrane microdomain termed "glycosynapse", and forms complexes with co-localized cell signaling molecules, including Src family kinases, certain tetraspanins (e.g., CD9, CD81, CD82), integrins, and GFRs (e.g., fibroblast growth factor receptor and hepatocyte growth factor receptor c-Met).
Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis.
Wang et al., Linqing, China. In Genet Mol Res, 2014
The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree.
Chromophobe renal cell carcinoma, eosinophilic variant with papillary growth: a case report.
Shuin et al., Kōchi, Japan. In Int J Clin Exp Pathol, 2014
Immunohistochemical staining with anti-monoclonal antibody 31 and -CD82 antibody, and choroid iron staining, were positive.
Recent advances of immunohistochemistry for diagnosis of renal tumors.
Review
Nagashima et al., Kōchi, Japan. In Pathol Int, 2013
CD82 and epithelial-related antigen (MOC31) may be helpful in the distinction between chromophobe RCC and renal oncocytoma.
Carbohydrate to carbohydrate interaction in development process and cancer progression.
Review
Hakomori et al., United States. In Glycoconj J, 2012
Also, the complex with GM3 and GM2 has been shown to inhibit the activation of hepatocyte growth factor (HGF) receptor, cMet, through its association with tetraspanin CD82, and results in the inhibition of cell motility.
Utility of immunohistochemical analysis of KAI1, epithelial-specific antigen, and epithelial-related antigen for distinction of chromophobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma.
GeneRIF
Uemura et al., Hirakata, Japan. In Med Mol Morphol, 2012
Results suggest that immunohistochemical analysis of CD82 (KAI1) and epithelial-specific antigen (ESA) to distinguish chromophobe renal cell carcinoma (ChRCC) from renal oncocytoma (RO).
CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro.
GeneRIF
Yan et al., Dalian, China. In Exp Biol Med (maywood), 2012
CD82 expression affects endometrial receptivity of the uterine epithelial cells in vitro
KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer.
GeneRIF
Lee et al., Seoul, South Korea. In Bmc Cancer, 2011
These novel observations may indicate that KAI1 exerts profound metastasis-suppressor activity in the tumor malignancy process via inhibition of CDCP1-mediated Src activation, followed by VHL-induced HIF-1alpha degradation and decreased VEGF expression.
CsA improves the trophoblasts invasiveness through strengthening the cross-talk of trophoblasts and decidual stromal cells mediated by CXCL12 and CD82 in early pregnancy.
GeneRIF
Li et al., Shanghai, China. In Int J Clin Exp Pathol, 2011
Cyclosporin A promotes trophoblasts invasiveness by stimulating the secretion of CXCL12, and also limits the invasiveness of trophoblasts by indirectly up-regulating the expression CD82.
Expression of CD82 in human trophoblast and its role in trophoblast invasion.
GeneRIF
Tan et al., Chongqing, China. In Plos One, 2011
Findings suggest that CD82 is an important negative regulator at maternal-fetal interface during early pregnancy, inhibiting human trophoblast invasion and migration.
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
Review
GeneRIF
Weissman et al., Frederick, United States. In Febs Lett, 2011
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
Tetraspanin functions during HIV-1 and influenza virus replication.
Review
Thali, Burlington, United States. In Biochem Soc Trans, 2011
We and others have shown that (i) HIV-1 assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of these proteins at exit sites and in viral particles inhibits virus-induced membrane fusion.
Chfr is linked to tumour metastasis through the downregulation of HDAC1.
Impact
Seol et al., Seoul, South Korea. In Nat Cell Biol, 2009
Ectopic expression of Chfr in cancer cells that normally do not express it results in downregulation of HDAC1, leading to upregulation of the Cdk inhibitor p21(CIP1/WAF1) and the metastasis suppressors KAI1 and E-cadherin.
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.
Impact
GeneRIF
Weissman et al., Frederick, United States. In Nat Med, 2007
gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
The DARC side of metastasis: shining a light on KAI1-mediated metastasis suppression in the vascular tunnel.
Impact
Quigley et al., Nashville, United States. In Cancer Cell, 2006
In the August issue of Nature Medicine, demonstrate that specific cell surface interactions between the metastasis suppressor KAI1 on tumor cells and the decoy cytokine receptor DARC on adjacent vascular cells triggers senescence in the tumor cells and suppresses metastasis.
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression.
Impact
Watabe et al., Springfield, United States. In Nat Med, 2006
CD82, also known as KAI1, was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.
Impact
Baek et al., Seoul, South Korea. In Nat Cell Biol, 2006
Recently, we have reported the dynamic role of a beta-catenin-reptin chromatin remodelling complex in regulating a metastasis suppressor gene KAI1 (ref.1), which is capable of inhibiting the progression of tumour metastasis.
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