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Centrosomal protein 170kDa

KAB, Cep170
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Kir4.1, KIR, ROMK
Papers on KAB
[Limiting metabolic steps in the utilization of D-xylose by recombinant Ralstonia eutropha W50-EAB].
New
Weng et al., In Wei Sheng Wu Xue Bao, Mar 2015
The resulting recombinant plasmids were transformed into W50-EAB to generate W50-KAB, W50-CAB and W50-TAB, respectively.
Gene expression microarray analysis of the sciatic nerve of mice with diabetic neuropathy.
New
Wang et al., Shanghai, China. In Int J Mol Med, Feb 2015
Three genes [myristoylated alanine-rich protein kinase C substrate (Marcks), GLI pathogenesis-related 2 (Glipr2) and centrosomal protein 170 kDa (Cep170)] were found to be co-regulated by both STZ and Rosi, the protein structure of which was predicted and certain binding activity to Rosi was docked.
Mutagenetic and electron microscopy analysis of actin filament severing by Cordon-Bleu, a WH2 domain protein.
Carlier et al., Gif-sur-Yvette, France. In Cytoskeleton (hoboken), 2014
To understand which primary sequence elements determine the filament severing activity of the WH2 repeats, here we combine a mutagenetic/domain swapping approach of the minimal fully active Cobl-KAB construct, which comprises the lysine rich region K preceding the two first WH2 domains A and B. The mutated Cobl constructs display variable loss of the original filament nucleating activities of native Cobl-KAB, without any strict correlation with a loss in actin binding, which emphasizes the functional importance of the electrostatic environment of WH2 domains.
The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.
Cheeseman et al., Cambridge, United States. In Mol Biol Cell, 2012
We identify the spindle-localized proteins Cep170 and Cep170R (KIAA0284) as specifically associating with Kif2b.
Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors.
McKay et al., Pasadena, United States. In Acs Chem Neurosci, 2012
Three amino acids (Phe118, Glu60, and Thr58) on the β2 subunit were shown to participate in the inhibitory properties of the selective antagonist KAB-18 and provided insights into its antagonism of human α4β2 nAChRs.
Covering their butts: responses to the cigarette litter problem.
McDaniel et al., San Francisco, United States. In Tob Control, 2011
The industry developed anti-litter programs with Keep America Beautiful (KAB) and similar organisations.
Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors.
Li et al., Columbus, United States. In Plos One, 2010
The T58K mutation resulted in an eight-fold decrease in the potency of KAB-18, a compound that exhibits preferential antagonism for human α4β2 over α3β4 nAChRs, while the F118L mutation resulted in a loss of inhibitory activity for KAB-18 at concentrations up to 100 µM.
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.
McKay et al., Columbus, United States. In J Pharmacol Exp Ther, 2010
A lead molecule, KAB-18, was identified that shows relative selectivity for Halpha4beta2 nAChRs.
Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs.
Grimbert et al., Grenoble, France. In Crit Care, 2008
A two-compartment model (blood and alveoli) was used to calculate KAB, the transport rate coefficient of FITC-D70 from blood to alveoli.
Validity of methyl mercury hair analysis: mercury monitoring in human scalp/nude mouse model.
Clarkson et al., Rochester, United States. In J Appl Toxicol, 2008
RESULTS: Human scalp hair grown in nude mice showed long-term persistence of human features including the expression of histocompatibility antigens (KAB 3, W 6/32, SF 1-1.1.1)
Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms.
Duensing et al., Pittsburgh, United States. In Virology, 2008
Here, we determined the frequency of centrosome overduplication in HPV-associated anal lesions using a recently identified marker for mature maternal centrioles, Cep170.
Cep164, a novel centriole appendage protein required for primary cilium formation.
Nigg et al., Martinsried, Germany. In J Cell Biol, 2007
In contrast to ninein and Cep170, two components of subdistal appendages, Cep164 persisted at centrioles throughout mitosis.
p21(Waf1/Cip1) deficiency stimulates centriole overduplication.
Duensing et al., Pittsburgh, United States. In Cell Cycle, 2006
Using a novel marker for maternal centrioles, Cep170, we show here that knock-down of p21 protein expression in murine myeloblasts can stimulate excessive centriole numbers in the presence of only one mature centriole.
The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
GeneRIF
Nigg et al., Martinsried, Germany. In Mol Biol Cell, 2005
Cep170 interacts with Polo-like kinase 1 in mature centrioles [Cep170]
Inwardly rectifying potassium channels: their molecular heterogeneity and function.
Review
Kurachi et al., Suita, Japan. In Jpn J Physiol, 1997
ROMK1 and KAB-2 are characterized with a Walker type-A ATP-binding motif in their carboxyl termini, and may be involved in K+ transport in renal epithelial and brain glial cells.
[Molecular and biophysical aspects of potassium channels].
Review
Kurachi et al., Ōsaka, Japan. In Nihon Rinsho, 1996
Several types of inwardly rectifying K+ channels, containing two putative transmembrane domains in each subunit, have recently been cloned and can be classified into four groups: 1) IRK family; classical inward rectifying, 2) GIRK family; G-protein-activated, 3) KATP family; ATP-inhibited, and 4) KAB family; ATP-dependent.
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