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Glutamate receptor, ionotropic, kainate 5

glutamate receptor subunit KA2; associates with subunits of the GluR5-7 family to form heteromeric kainate-preferring glutamate receptpors [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GluR6, KA1, metabotropic glutamate receptor, ACID, GluR1
Papers on KA2
Identifying a Highly Active Copper Catalyst for KA2 Reaction of Aromatic Ketones.
Ma et al., Shanghai, China. In Chemistry, Jan 2016
UNASSIGNED: The well-established A3-coupling reaction of terminal alkynes, aldehydes, and amines provides the most straightforward approach to propargylic amines.
Isolation and characterization of a novel marine Bacteroidetes as Algitalea ulvae gen. nov., sp. nov., isolated from the green alga Ulva pertusa.
Kasai et al., Taegu, South Korea. In Antonie Van Leeuwenhoek, Aug 2015
A polyphasic taxonomic investigation was performed on a bacterial strain, 38-Ka-2(T), which was isolated from the green alga Ulva pertusa Kjellman (Chlorophyta) in Hokkaido, Japan.
Large-scale biodiesel production using flue gas from coal-fired power plants with Nannochloropsis microalgal biomass in open raceway ponds.
Pan et al., Qingdao, China. In Bioresour Technol, 2014
In this study, three strains of the genus Nannochloropsis (4-38, KA2 and 75B1) survived this type of culture and bloomed using flue gas from coal-fired power plants in 8000-L open raceway ponds.
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Kosaki et al., Tokyo, Japan. In Am J Med Genet A, 2014
Among the five known GRIK family members, haploinsufficiency of GRIK1, GRIK2, and GRIK4 are known to cause developmental delay, whereas the roles of GRIK3 and GRIK5 remain unknown.
N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia.
Meador-Woodruff et al., Birmingham, United States. In Neuroreport, 2013
The NR1, NR2A, NR2B, GluR6, and KA2 subunits were all sensitive to treatment with Endo H and PNGase F. The GluR6 KA receptor subunit was significantly more sensitive to Endo H-mediated deglycosylation in schizophrenia, suggesting a larger molecular mass of N-linked high mannose and/or hybrid sugars on GluR6.
Therapeutic drug monitoring and pharmacokinetic compartmental analysis of sulpiride double-peak absorption profile after oral administration to human volunteers.
Helmy, Damanhûr, Egypt. In Biopharm Drug Dispos, 2013
The parameters determined were k21 (0.68±0.2 h(-1)), ka1 (0.7±0.27 h(-1)), ka2 (2.7±1.8 h(-1)) Vc/F (45.1±15.7 L), α (33.3±1.5 h(-1)), β (0.11±0.03 h(-1)) and time for the beginning of the absorption from the second site (4.4±2.1 h).
Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors.
Banik et al., Charleston, United States. In Neuroscience, 2012
In addition we detected increases in metabotropic glutamate receptor (mGluR) 2/3, mGluR5 and kainic acid receptor subunits KA1 (Grik4) and KA2 (Grik5) in patients' hippocampi.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that Grik5 gene expression in mouse dorsal raphe nucleus
Synaptic Pattern of KA1 and KA2 upon the Direction-Selective Ganglion Cells in Developing and Adult Mouse Retina.
Jeon et al., Taegu, South Korea. In Acta Histochem Cytochem, 2012
In this article, we investigated the distributions of kainate glutamate receptor subtypes KA1 and KA2 on the dendritic arbors of DS-RGCs in developing (5, 10) days postnatal (PN) and adult mouse retina to search for anisotropies.
Distinct functional roles of subunits within the heteromeric kainate receptor.
Mott et al., Columbia, United States. In J Neurosci, 2011
Heteromeric GluK2/K5 receptors expressed in human HEK-293T cells show markedly higher glutamate sensitivity than GluK2 homomers and do not desensitize at low glutamate concentrations.
Subtype selective kainic acid receptor agonists: discovery and approaches to rational design.
Krogsgaard-Larsen et al., Copenhagen, Denmark. In Med Res Rev, 2009
Within the iGluRs, five subtypes (KA1, KA2, iGluR5-7) show high affinity and express full agonist activity upon binding of the naturally occurring amino acid kainic acid (KA).
Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes.
Jacobson et al., Bethesda, United States. In J Neuroimmune Pharmacol, 2008
Functional dysregulation of glutamate uptake was associated with early increases in mRNA and protein expression of the glial glutamate transporter EAAT-2 followed by a sustained decrease in mRNA expression in astrocytes infected with both HHV-6A & HHV-6B.
Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2.
Roche et al., Bethesda, United States. In J Neurosci, 2006
Trafficking motifs in both intracellular loop and C terminus regulate KA2 surface expression; however, in neurons, GluR6 oligomerization is required for egress of KA2 from endoplasmic reticulum and transport to cell surface.
Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I (COPI) and 14-3-3 chaperone systems.
Swanson et al., Galveston, United States. In J Biol Chem, 2006
Association between COPI proteins and KA2 subunits was significantly reduced upon alanine substitution of this signal in the cytoplasmic tail of KA2.
Peripheral glutamate receptors: molecular biology and role in taste sensation.
Conn et al., Atlanta, United States. In J Nutr, 2000
Fifteen functional subunits assemble together in heteromultimeric complexes to form these receptors as follows: GluR1-GluR4 for AMPA; GluR5-GluR7 and KA1-KA2 for kainate; and NR1, NR2A-NR2D and NR3 for NMDA receptors.
Genetic regulation of glutamate receptor ion channels.
Borges et al., Atlanta, United States. In Annu Rev Pharmacol Toxicol, 1998
The promoters of the genes that encode the NR1, NR2B, NR2C, GluR1, GluR2, and KA2 subunits share several characteristics that include multiple transcriptional start sites within a CpG island, lack of TATA and CAAT boxes, and neuronal-selective expression.
The synaptic activation of kainate receptors.
Collingridge et al., Bristol, United Kingdom. In Nature, 1997
Kainate receptors are formed from a separate set of genes (GluR5-7, KA-1 and KA-2) and are widely distributed throughout the brain.
Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.
Huganir et al., Baltimore, United States. In Nature, 1993
On the basis of sequence similarity and pharmacological properties, the recently cloned glutamate receptor subunits have been assigned as components of NMDA (NMDAR1, 2A-D), AMPA (GluR1-4) and KA (GluR5-7, KA1, KA2) receptors.
Additive inheritance of resistance to pod rot caused by Phytophthora palmivora in cocoa.
Tan et al., Portugal. In Theor Appl Genet, 1990
Other parental clones - KA2-101, KA5-201, KEE 2, KEE 5, and KEE 52 - produced progenies which were susceptible to Ppr.
Properties of immunoglobulin G-Fc receptors from neonatal rat intestinal brush borders.
Rees et al., In Ciba Found Symp, 1982
Two classes of binding site are resolved by their affinities (KA1 = 1.3 X 10(8) M; KA2 = 5.15 X 10(6) M).
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