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Glutamate receptor, ionotropic, kainate 4

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KA2, GluR6, metabotropic glutamate receptor, ACID, GluR1
Papers using KA1 antibodies
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
Lauri Sari E. et al., In Scientific Reports, 2006
... Developmental profile of kainate receptor subunit KA1 revealed by Cre expression in YAC transgenic mice ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
Shen Jie et al., In Nature, 2001
... We would like to thank Kazu Nakazawa and Susumu Tonegawa for KA1-Cre transgenic mice, Ray Kelleher for ...
Papers on KA1
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study.
Braff et al., San Diego, United States. In Schizophr Res, Jan 2016
Genotyping via a custom array of 1536 SNPs from 94 candidate genes identified associations for CTNNA2, ERBB4, GRID1, GRID2, GRIK3, GRIK4, GRIN2B, NOS1AP, NRG1, and RELN across multiple endophenotypes.
Optimization of crude oil degradation by Dietzia cinnamea KA1, capable of biosurfactant production.
Ghasempour et al., Tehrān, Iran. In J Basic Microbiol, Dec 2015
Among 11 isolates, 5 were able to emulsify crude oil in Minimal Salt Medium (MSM) among which one isolate, named KA1, showed the highest potency for growth rate and biodegradation.
Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.
Lerma et al., San Juan de Alicante, Spain. In J Neurosci, Nov 2015
Among these genes is GRIK4, a gene coding for a glutamate receptor subunit of the kainate type.
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
Sasai et al., Kōbe, Japan. In Nat Commun, 2014
Following long-term dissociation culture, these dorsomedial telencephalic tissues give rise to Zbtb20(+)/Prox1(+) granule neurons and Zbtb20(+)/KA1(+) pyramidal neurons, both of which were electrically functional with network formation.
Structural insight into the mechanism of synergistic autoinhibition of SAD kinases.
Wu et al., Beijing, China. In Nat Commun, 2014
Like other members of the AMPK family, SAD contains an N-terminal kinase domain followed by the characteristic UBA and KA1 domains.
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
Kosaki et al., Tokyo, Japan. In Am J Med Genet A, 2014
Among the five known GRIK family members, haploinsufficiency of GRIK1, GRIK2, and GRIK4 are known to cause developmental delay, whereas the roles of GRIK3 and GRIK5 remain unknown.
European Group for the Study of Resistant Depression (GSRD)--where have we gone so far: review of clinical and genetic findings.
Kasper et al., Vienna, Austria. In Eur Neuropsychopharmacol, 2012
Additional investigated candidate genes were DTNBP1, 5HT1A, PTGS2, GRIK4 and GNB3.
Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.
Contractor et al., Chicago, United States. In Behav Brain Res, 2012
This study demonstrated a clear anxiolytic and antidepressant phenotype associated with ablation of Grik4 and a parallel disruption in hippocampal plasticity.
GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status.
Pickard et al., Edinburgh, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2012
The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells.
Regulation of protein kinases by lipids.
Hurley et al., Bethesda, United States. In Curr Opin Struct Biol, 2011
Recent structural studies have identified a new membrane association domain, the Kinase Associated 1 (KA1) domain, which targets a number of yeast and mammalian protein kinases to membranes containing acidic phospholipids.
Glutamate signaling through the kainate receptor enhances human immunoglobulin production.
Conrad et al., Richmond, United States. In J Neuroimmunol, 2011
Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production.
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Lemmon et al., Philadelphia, United States. In Cell, 2011
Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids.
Kinases charging to the membrane.
Williams et al., Cambridge, United Kingdom. In Cell, 2011
In this issue, Moravcevic and colleagues (2010) survey membrane-interacting proteins in yeast and discover a new membrane-targeting module, the kinase associated-1 domain KA1, which ensures that proteins are active at the correct place and time.
Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice.
Han et al., Chŏnju, South Korea. In J Vet Sci, 2010
the KA1 KAR subunits are expressed in the SG of the Vc in mice and that the expression level of the KA1 KAR subunit decreases gradually with postnatal development.
Presynaptic kainate receptors increase GABAergic neurotransmission in rat periaqueductal gray neurons.
Jang et al., Taegu, South Korea. In Eur J Pharmacol, 2010
Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability.
The genetics of bipolar disorder.
Smoller et al., Boston, United States. In Neuroscience, 2009
Several of these genes have been associated with the disorder in independent studies (including BDNF, DAOA, DISC1, GRIK4, SLC6A4, and TPH2), but none has been established.
Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia.
Muir et al., Edinburgh, United Kingdom. In Neurotox Res, 2008
The genes GRIK4 and NPAS3, each associated with psychosis in patients with mental retardation are discussed to illustrate the value of rare cytogenetic events as a means to signpost neurobiological pathways of general importance for illness in the wider population.
Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses.
Isaac et al., Bristol, United Kingdom. In Nature, 1999
Although kainate-receptor subunits (GluR5-7, KA1 and 2) are widely expressed in the mammalian central nervous system, little is known about their function.
The synaptic activation of kainate receptors.
Collingridge et al., Bristol, United Kingdom. In Nature, 1997
Kainate receptors are formed from a separate set of genes (GluR5-7, KA-1 and KA-2) and are widely distributed throughout the brain.
Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.
Huganir et al., Baltimore, United States. In Nature, 1993
On the basis of sequence similarity and pharmacological properties, the recently cloned glutamate receptor subunits have been assigned as components of NMDA (NMDAR1, 2A-D), AMPA (GluR1-4) and KA (GluR5-7, KA1, KA2) receptors.
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