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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratin 36

K36, Keratin-5, HA6
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, HAIR, CAN, HAD, POLYMERASE
Papers on K36
Enzymatic production of specifically distributed hyaluronan oligosaccharides.
New
Kang et al., Wuxi, China. In Carbohydr Polym, Oct 2015
By modulating the concentrations of HAase and controlling the hydrolysis time, any molar-mass-defined HA oligomers could be efficiently and specifically produced on a large scale (40 g/L), such as HA oligosaccharides with weight-average molar mass of 4000, 10,000, and 30,000Da and end hydrolysates containing only HA6 and HA4.
Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice.
Lan et al., Hong Kong, Hong Kong. In Am J Respir Cell Mol Biol, 2014
To investigate the role of circulating latent TGF-β1 in bleomycin-induced lung injury, lung disease was induced in keratin-5 promoter-driven TGF-β1(wt) transgenic (Tg) mice by bleomycin.
Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice.
Akiyama et al., Tokyo, Japan. In Plos One, 2014
Exposure of mice to 2G for three days reduced the frequency of CD4+CD8+ thymocytes (DP) and mature medullary thymic epithelial cells (mTECs), accompanied by an increment of keratin-5 and keratin-8 double-positive (K5+K8+) TECs that reportedly contain TEC progenitors.
CtBP1 overexpression in keratinocytes perturbs skin homeostasis.
Zhang et al., Aurora, United States. In J Invest Dermatol, 2014
We generated keratinocyte-specific CtBP1 transgenic mice with a keratin-5 promoter (K5.CtBP1) to probe the pathological roles of CtBP1.
Superficial dermal fibroblasts enhance basement membrane and epidermal barrier formation in tissue-engineered skin: implications for treatment of skin basement membrane disorders.
Tredget et al., Edmonton, Canada. In Tissue Eng Part A, 2014
Tissue-engineered skin with superficial fibroblasts and keratinocytes formed a continuous epidermis with increased epidermal barrier function and expressed higher levels of epidermal proteins, keratin-5, and E-cadherin, compared to that with deep fibroblasts and keratinocytes, which had an intermittent epidermis.
MMP-9 and CXCL8/IL-8 are potential therapeutic targets in epidermolysis bullosa simplex.
Wally et al., Salzburg, Austria. In Plos One, 2012
Dowling-Meara, the major subtype of epidermolysis bullosa simplex, is inherited in an autosomal dominant manner and can be caused by mutations in either the keratin-5 (K5) or the keratin-14 (K14) gene.
Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis.
Mills et al., Austin, United States. In Oncogene, 2012
To test this idea, we generated a mouse model that expresses an epidermal-targeted keratin-5-UCP3 (K5-UCP3) transgene and exhibits significantly increased cutaneous mitochondrial respiration compared with wild type (FVB/N).
IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin.
Hu et al., United States. In Cell Death Differ, 2011
In the present study, we generated two mouse lines that expressed different levels of transgenic IKKα in the basal epidermis under the control of keratin-5 promoter and further evaluated their effects on the major pathways of inflammation, proliferation, and differentiation in the skin.
Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2).
Willecke et al., Bonn, Germany. In J Cell Sci, 2011
By contrast, keratin-5-Cre-mediated replacement of Cx26 with Cx32 or deletion of both Cx26 alleles revealed severe lymphedemas similar to the general Cx26KICx32 phenotype.
Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia.
Hursting et al., United States. In Cancer Prev Res (phila), 2011
Administration of a 30% CR diet for 14 weeks decreased serum IGF-1 levels and hindered pancreatic ductal lesion formation and dysplastic severity, relative to a higher calorie control diet, in transgenic mice overexpressing COX-2 [bovine keratin-5 promoter (BK5.COX-2)].
Enhanced isolation of adult thymic epithelial cell subsets for multiparameter flow cytometry and gene expression analysis.
Manilay et al., Merced, United States. In J Immunol Methods, 2011
Intracellular staining for keratin-5 and keratin-8 can also be added, but our results suggest that keratin expression alone cannot be used to distinguish adult TEC subsets.
Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge.
Varadarajan et al., Bengaluru, India. In Proc Natl Acad Sci U S A, 2010
The resulting construct (HA6) was expressed in Escherichia coli and refolded from inclusion bodies.
Toxic effects of D-galactose on thymus and spleen that resemble aging.
Isobe et al., Nagoya, Japan. In J Immunotoxicol, 2010
The results showed that galactose-treated mice develop histologic changes in their thymic cortical and medullary regions; immunohistochemical analysis revealed unorganized distributions of keratin-5 and keratin-8 proteins in the thymus of these hosts.
Dystroglycan is not required for maintenance of the luminal epithelial basement membrane or cell polarity in the mouse prostate.
Henry et al., Iowa City, United States. In Prostate, 2010
Dystroglycan expression remains in keratin-5-positive basal cells located in the proximal ducts where dystroglycan expression is elevated in regenerating prostates.
Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells.
GeneRIF
Richie et al., United States. In J Immunol, 2007
medulla formation and central tolerance depend on activating the alternative NF-kappaB signaling pathway selectively in keratin 5-expressing medullary thymic epithelial cells
Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth.
GeneRIF
Vaitheesvaran et al., Los Angeles, United States. In J Biol Chem, 2003
interaction with amelogenin in ameloblasts during enamel growth
Extracellular matrix recovery by human articular chondrocytes after treatment with hyaluronan hexasaccharides or Streptomyces hyaluronidase.
Knudson et al., Nagoya, Japan. In Mod Rheumatol, 2003
Abstract The treatment of human articular chondrocytes with Streptomyces hyaluronidase (St-HA'ase) or hyaluronan hexasaccharides (HA6) provides two approaches to the selective depletion of specific components of the extracellular matrix, and an opportunity to follow the reparative responses initiated by these changes.
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