Enzymatic production of specifically distributed hyaluronan oligosaccharides.
Wuxi, China. In Carbohydr Polym, Oct 2015
By modulating the concentrations of HAase and controlling the hydrolysis time, any molar-mass-defined HA oligomers could be efficiently and specifically produced on a large scale (40 g/L), such as HA oligosaccharides with weight-average molar mass of 4000, 10,000, and 30,000Da and end hydrolysates containing only HA6 and HA4.
Toxic effects of D-galactose on thymus and spleen that resemble aging.
Nagoya, Japan. In J Immunotoxicol, 2010
The results showed that galactose-treated mice develop histologic changes in their thymic cortical and medullary regions; immunohistochemical analysis revealed unorganized distributions of keratin-5 and keratin-8 proteins in the thymus of these hosts.