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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratin 76

K2P, K76, cytokeratin 2
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009] (from NCBI)
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Top mentioned proteins: CAN, TREK-1, ACID, HAD, TASK-3
Papers on K2P
Potassium channels in neuropathic pain: advances, challenges, and emerging ideas.
New
López García et al., Madrid, Spain. In Pain, Feb 2016
Two kinds of potassium channels were particularly evoked: selected subunits of the voltage-gated potassium (Kv) and of the K2P channel families.
The 'species complex' issue in clinically relevant fungi: A case study in Scedosporium apiospermum.
New
Lackner et al., Shanghai, China. In Fungal Biol, Feb 2016
In the present study, four additional genetic loci were explored from a phylogenetic point of view enabling a barcoding approach based on K2P pairwise distances to resolve the taxa Scedosporium.
DNA barcoding Indian freshwater fishes.
New
Ayyappan et al., Mumbai, India. In Mitochondrial Dna, Jan 2016
The average Kimura two-parameter (K2P) distances within-species, genera, families, and orders were 0.40%, 9.60%, 13.10%, and 17.16%, respectively.
Identification, Discrimination, and Discovery of Species of Marine Planktonic Ostracods Using DNA Barcodes.
New
Bucklin et al., Southampton, United Kingdom. In Plos One, Dec 2015
Kimura-2-Parameter (K2P) genetic distances within described species (mean = 0.010 ± 0.017 SD) were significantly smaller than between species (0.260 + 0.080), excluding eight taxa hypothesized to comprise cryptic species due to morphological variation (especially different size forms) and/or collection from different geographic regions.
Role of leak potassium channels in pain signaling.
Review
New
Toyoda et al., China. In Brain Res Bull, Oct 2015
Two-pore domain (K2P) "leak" K(+) channels give rise to leak K(+) currents that are responsible for the resting membrane potential and input resistance.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
Review
New
Brohawn, New York City, United States. In Ann N Y Acad Sci, Sep 2015
The ability to sense and respond to mechanical forces is essential for life and cells have evolved a variety of systems to convert physical forces into cellular signals.
Emerging potassium channel targets for the treatment of pain.
Review
New
Tsantoulas, London, United Kingdom. In Curr Opin Support Palliat Care, Jun 2015
K2P) whereas others are specifically modulated by inflammatory processes (Kv7, BKCA, K2P).
Much more than a leak: structure and function of K₂p-channels.
Review
New
Daut et al., Marburg an der Lahn, Germany. In Pflugers Arch, May 2015
Over the last decade, we have seen an enormous increase in the number of experimental studies on two-pore-domain potassium channels (K2P-channels).
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
New
Impact
Carpenter et al., Oxford, United Kingdom. In Science, Apr 2015
TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs.
The cost of liver disease in Korea: methodology, data, and evidence.
Review
New
Chung, Ch'unch'ŏn, South Korea. In Clin Mol Hepatol, Mar 2015
EVIDENCE: The number of deaths due to liver cancer (C22) increased from 6,384 in 1983 to 11,405 in 2013, while deaths due to other liver diseases (K70-K76) increased from 12,563 in 1983 to 13,458 in 1995, and then declined to 6,665 in 2013.
Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.
Review
Impact
Niemeyer et al., Valdivia, Chile. In Physiol Rev, 2015
Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels.
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Impact
MacKinnon et al., New York City, United States. In Nature, 2015
TRAAK (also known as KCNK4) ion channels are neuronally expressed members of the two-pore domain K(+) (K2P) channel family and are mechanosensitive.
Description and DNA barcoding of a new Iberian species of Pijnackeria (Scali, 2009) from Sierra Nevada, Spain (Phasmida: Diapheromeridae).
Ortiz et al., Murcia, Spain. In Zootaxa, 2014
For COI, K2P minim-um distance between the new species and the most morphological related species, Pijnackeria hispanica (Bolívar, 1878), showed a mean of 8%.
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.
Review
Impact
Olesen et al., In Physiol Rev, 2014
Three main K+ channels drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels.
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Impact
MacKinnon et al., New York City, United States. In Science, 2012
TRAAK channels, members of the two-pore domain K(+) (potassium ion) channel family K2P, are expressed almost exclusively in the nervous system and control the resting membrane potential.
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