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Keratin 16

K16, keratin 16, cytokeratin 16, CK16
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using K16 antibodies
ArrayExpress
Supplier
Ashcroft Gillian S et al., In Genome Biology, 2002
... antibody (R&D Systems, Abingdon, UK), anti-LOR, anti-INV (Covance, Berkeley, CA, USA), JCMC (rabbit polyclonal anti-Dsc1), anti-K16, anti-ARG1 (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Monoclonal antibody analysis of keratin expression in epidermal diseasesa 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes
Supplier
Coulombe Pierre A. et al., In The Journal of Cell Biology, 1983
... Two K16-C14 and four K16 transgenic lines were generated with ...
Papers on K16
Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.
GeneRIF
Coulombe et al., Baltimore, United States. In J Invest Dermatol, 2012
we show that the loss of Krt16 function in mice causes the development of prominent calluses on the plantar side of front and hind paws, which significantly compromise mobility.
Pachyonychia congenita patients with mutations in KRT6A have more extensive disease compared with patients who have mutations in KRT16.
GeneRIF
Tang et al., Stanford, United States. In Br J Dermatol, 2012
Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system.
Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations.
GeneRIF
Tang et al., Stanford, United States. In J Invest Dermatol, 2011
Patients with p.Asn125Asp and p.Arg127Pro mutations in KRT16 exhibited more severe disease than patients carrying p.Asn125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail involvement, and impact on daily quality of life.
Trichohyalin is a potential major autoantigen in human alopecia areata.
GeneRIF
Tobin et al., Bradford, United Kingdom. In J Proteome Res, 2010
Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder.
Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT keratinocytes results in diminished cellular migration.
GeneRIF
Onder et al., Salzburg, Austria. In Mech Ageing Dev, 2010
these data highlight the possibility of a physiological role for K6/K16 heterodimers in keratinocyte cell migration, in addition to the heterodimer's known functions in cell differentiation and mechanical resilience.
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