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Keratin 15

K15, keratin 15, CK15, cytokeratin 15
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, HAIR, CAN, cytokeratin 19, CD34
Papers on K15
Constructing Human Skin Equivalents on Porcine Acellular Peritoneum Extracellular Matrix for In Vitro Irritation Testing.
New
Michniak-Kohn et al., United States. In Tissue Eng Part A, Jan 2016
The epidermis of APM-HSEs expressed keratin 15, a keratinocyte proliferation marker, and involucrin, a differentiation marker, respectively.
Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma.
New
Bae et al., Taegu, South Korea. In Int J Dermatol, Jan 2016
METHODS: The labeling index and differences of expression of the immunohistochemical (IHC) stainings of CK15, CK19, follistatin, and Bmi-1 were evaluated in 20 cases of BCC, 13 cases of trichoblastoma, 21 cases of actinic keratosis (AK), and 19 cases of squamous cell carcinoma (SCC) which were biopsied in the department of dermatology of the Yeungnam University Medical Center.
TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles.
New
Xu et al., Philadelphia, United States. In Lab Invest, Jan 2016
Immunohistochemical staining confirms that TR3 is highly expressed in the bulge region of human hair follicles and it colocalizes with cytokeratin 15 (K15), an epithelial stem cell marker.
The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles.
New
Hirobe et al., Chiba, Japan. In Int J Radiat Biol, Dec 2015
Effects of γ-rays on hair follicle stem cells were investigated by the indirect immunolabeling of keratin 15 (K15).
Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction.
New
Rafat et al., Tampere, Finland. In Exp Eye Res, Dec 2015
Cell proliferation of hPSC-LESCs was significantly higher on bioengineered matrices than on collagen-coated control wells after two weeks of culture, and LESC markers p63 and cytokeratin 15, along with proliferation marker Ki67 were expressed even after 30 days in culture.
Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma.
New
Sugiyama et al., Kyoto, Japan. In J Glaucoma, Dec 2015
Ectopic epithelial cells were abundantly positive for CK15, a limbal basal cell marker, but there was patchy immunostaining of CK13, a conjunctival epithelial marker, and sparse labeling with CK12, a corneal epithelial marker.
Long-Term Cultures of Human Cornea Limbal Explants Form 3D Structures Ex Vivo - Implications for Tissue Engineering and Clinical Applications.
Petrovski et al., Szeged, Hungary. In Plos One, 2014
The outgrowing cells were examined by immunofluorescent staining for putative markers of stemness (ABCG2, CK15, CK19 and Vimentin), proliferation (p63α, Ki-67), limbal basal epithelial cells (CK8/18) and differentiated cornea epithelial cells (CK3 and CK12).
Human corneal stromal stem cells support limbal epithelial cells cultured on RAFT tissue equivalents.
Daniels et al., London, United Kingdom. In Sci Rep, 2014
Our results demonstrate that a monolayer of HLE that maintained expression of p63α, ABCB5, CK8 and CK15 (HLE markers), formed on the surface of RAFT TEs within 13 days of culture.
Advances in a rapidly emerging field of hair follicle stem cell research.
Review
Mosler et al., In Coll Antropol, 2014
The research of these cells emerged rapidly after the identification of bulge cell molecular markers, such as keratin 15 (K15) and CD34 in mice and CD200 in humans, which allowed the isolation and characterization of bulge cells from follicles.
Keratin k15 as a biomarker of epidermal stem cells.
Review
Waseem et al., London, United Kingdom. In Int J Mol Sci, 2012
Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia.
Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia.
GeneRIF
Nakamura et al., Hirosaki, Japan. In Int J Mol Med, 2012
Krt5 may be a novel biological marker for acute radiation symptoms.
Stem cells and alopecia: a review of pathogenesis.
Review
Al-Refu, Qīr Moāv, Jordan. In Br J Dermatol, 2012
To date, the best marker for bulge stem cells in human hair is cytokeratin (CK) 15; human bulge cells have been reported to express CK15 selectively throughout all stages of the hair cycle in different types of follicles.
Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.
GeneRIF
Yamaguchi et al., Tokyo, Japan. In Histol Histopathol, 2012
K15 is expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm
Angiogenesis potential of human limbal stromal niche cells.
GeneRIF
Tseng et al., Wuhan, China. In Invest Ophthalmol Vis Sci, 2012
both expanded limbal NCs and HUVEC rejoined with LEPC to form spheres to upregulate expression of DeltaNp63alpha, CK15, and CEBPdelta, the former but not the latter abolished expression of CK12 keratin.
Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification.
GeneRIF
Tan et al., Singapore, Singapore. In Breast Cancer Res Treat, 2012
Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders.
Re-assessing K15 as an epidermal stem cell marker.
GeneRIF
Turksen et al., Ottawa, Canada. In Stem Cell Rev, 2011
K15 protein expression may reflect not only expression in a stem or progenitor cell subpopulation, but also reflects the activity and responsiveness of basal-like cells to loss of homeostasis of the epidermal differentiation program.
Stem cell markers can help identify adnexal tumor differentiation when evaluated in the context of morphology: methodology matters.
Review
Sellheyer, Cleveland, United States. In J Cutan Pathol, 2011
Of those, cytokeratin 15, PHLDA1 (TDAG51) and CD200 offer the most promise.
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis.
Impact
Mills et al., United States. In Cell Stem Cell, 2011
Interestingly, bypass of senescence promotes stem-like proliferation and maintains survival of the keratin 15-positive stem cell population.
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
Impact
Epstein et al., Oakland, United States. In Cancer Cell, 2011
Using cell fate tracking of X-ray induced BCCs in Ptch1(+/-) mice, we found their essentially exclusive origin to be keratin 15-expressing stem cells of the follicular bulge.
Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus.
Review
GeneRIF
Goodfield et al., Qīr Moāv, Jordan. In Autoimmun Rev, 2009
marker of the hair follicle stem cells; diminished during scarring in alopecia and discoid lupus erythematosus
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