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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratin 14

K14, keratin 14, CK14, cytokeratin 14
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, p63, CAN, HAD, cytokeratin 19
Papers using K14 antibodies
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease.
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Kodavanti Urmila P. et al., In Environmental Health Perspectives, 2010
... were assessed for surfactant protein A (sc-7699), Clara cell protein 10 (sc-9772), cytokeratin 10 (sc-58720), and cytokeratin 14 (sc-53253) using antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Role of keratinocytes in healing of chronic wounds
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Li Bin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Guinea pig anti-K14 was purchased from RDI-Fitzgerald (Oaklyn, NJ, USA) ...
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Papers on K14
Gastro-duodenal fluid induced Nuclear Factor-κappaB activation and early pre-malignant alterations in murine hypopharyngeal mucosa.
New
Sasaki et al., New Haven, United States. In Oncotarget, Feb 2016
Early pre-malignant histologic lesions exhibited increased Ki67, CK14 and ΔNp63, cell proliferation markers, changes of cell adhesion molecules, E-Cadherin and β-catenin, and STAT3 activation.
Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype.
New
Shaaban et al., Kumasi, Ghana. In Pathobiology, Feb 2016
CK5/6 and CK14 (basal) and CK18 and 19 (luminal).
Reduced salivary gland size and increased presence of epithelial progenitor cells in DLK1-deficient mice.
New
Ibarretxe et al., Leioa, Spain. In Cell Tissue Res, Jan 2016
Finally, despite their lack of severe anomalies, we have found that salivary glands from Dlk1-deficient mice present a higher amount of CK14-positive epithelial progenitors at various developmental stages, suggesting a role for DLK1 in the regulation of salivary epithelial stem cell balance.
Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.
New
Müller et al., Manchester, United Kingdom. In Eur J Immunol, Jan 2016
Using keratin 14-Cre driver mice, new IL-1R1 deficient (-/-) mice were subsequently generated, in which all signaling IL-1 receptor isoforms are deleted ubiquitously.
Phenotypic and functional characterization of two bovine mammary epithelial cell lines in 2D and 3D models.
New
Dessauge et al., Cameroon. In Am J Physiol Cell Physiol, Jan 2016
Cytokeratin (CK14 and CK19), signal transducer and activator of transcription 5 (STAT5) and other proteins (Occludin and cadherin-1) were analyzed.
A Peripheral Dentinogenic Ghost Cell Tumor With Immunohistochemical Investigations and a Literature Review-Based Clinicopathological Comparison Between Peripheral and Central Variants.
Review
New
Lombardi et al., Sri Lanka. In Int J Surg Pathol, Sep 2015
Immunohistochemical investigations revealed similar cytokeratin expression pattern, with CK14 and MNF116 positivity in both the tumor and the surrounding surface epithelium.
Conjunctival inverted squamous papilloma: a case report with immunohistochemical analysis and review of the literature.
Review
New
Mendoza et al., Boston, United States. In Surv Ophthalmol, May 2015
Immunostaining was diffusely positive for cytokeratin (CK) 7, and CK14 stained the basilar and suprabasilar cells, as in normal conjunctiva.
Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature.
Review
Slone et al., Louisville, United States. In Mod Pathol, 2014
Like hepatocellular carcinoma, hepatoid adenocarcinoma of lung expresses CK8 (5/5), CK18 (5/5), AFP (3/5) and HepPar1 (5/5), shows cytoplasmic staining with TTF-1 (5/5) and does not express CK14 (0/5).
Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells.
Impact
Ueno et al., Hirakata, Japan. In Nat Cell Biol, 2013
Here, we show that stem cells positive for Bmi1, keratin 14 and keratin 5 are present in the base but not at the very bottom of the interpapillary pit (observed most frequently in the second or third layer (position +2 or +3) from the basal cells).
Stem cell research: a novel boulevard towards improved bovine mastitis management.
Review
Jeong et al., Cheju, South Korea. In Int J Biol Sci, 2012
Inner layer of columner/luminal cells of bovine MECs, is characterized by cytokeratin18, 19 (CK18, CK19) and outer layer such as myoepithelial cells which are characterized by CK14, α-smooth muscle actin (α-SMA) and p63.
Small cell carcinoma of the oral cavity (cheek mucosa): a case report with an immunohistochemical and molecular genetic analysis.
Review
Terada, Shizuoka, Japan. In Int J Clin Exp Pathol, 2012
Immunohistochemically, the tumor cells are positive for pancytokeratin (PCK) WSS, PCK MNF-116, cytokeratin (CK) 34BE12, CK5/6, CK14, vimentin, KIT (CD117), CD56, synaptophysin, p53 protein, and Ki67 antigen (Ki-67 labeling = 70%).
A half-site of the p53-binding site on the keratin 14 promoter is specifically activated by p63.
GeneRIF
Chen et al., Taipei, Taiwan. In J Biochem, 2012
One isoform of p63, TAp63alpha, can activate an epidermal basal cell marker, keratin 14.
Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath.
Review
GeneRIF
Lee et al., Baltimore, United States. In J Invest Dermatol, 2012
Defects in K5-K14 filament network architecture cause basal keratinocytes to become fragile, and account for their rupture upon exposure to mechanical trauma.
The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes.
GeneRIF
Fudge et al., Guelph, Canada. In Plos One, 2011
Mutant K14-R125P filaments and/or networks in human keratinocytes are mechanically defective in their response to large-scale deformations.
Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells.
GeneRIF
Vaidya et al., Mumbai, India. In Mol Biol Cell, 2011
Our results suggest that keratin 5 and keratin 14 may have a role in maintenance of cell proliferation potential in the basal layer of stratified epithelia
A new case of keratin 14 functional knockout causes severe recessive EBS and questions the haploinsufficiency model of Naegeli-Franceschetti-Jadassohn syndrome.
GeneRIF
Hovnanian et al., In J Invest Dermatol, 2011
keratin 14 functional knockout causes severe recessive epidermolysis bullosa simplex, and questions the haploinsufficiency model of Naegeli-Franceschetti-Jadassohn syndrome
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
Impact
Waksman et al., France. In Lancet, 2009
Expression levels of genes encoding keratin 14, keratin 5, integrin alpha6, integrin beta4, collagen VII, and laminin 5 in these cells were similar to those in basal keratinocytes.
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Impact
Nerlov et al., Monterotondo, Italy. In Nat Cell Biol, 2009
This led to ectopic expression of keratin 14 (K14) and DeltaNp63 in suprabasal cells, decreased expression of spinous and granular layer proteins, parakeratosis and defective epidermal water barrier function.
Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators.
Impact
kConFab Investigators et al., Brisbane, Australia. In J Clin Oncol, 2008
We specifically explored the value of estrogen receptor, cytokeratin 5/6, and cytokeratin 14 as tumor markers of BRCA1 mutation status.
Deregulated expression of c-Myc depletes epidermal stem cells.
Impact
Roop et al., Houston, United States. In Nat Genet, 2001
To determine the role of c-Myc in epidermal stem cells in vivo, we have targeted expression of human MYC2 to the hair follicles and the basal layer of mouse epidermis using a keratin 14 vector (K14.MYC2).
More papers using K14 antibodies
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
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Detmar Michael et al., In The Journal of Experimental Medicine, 2006
... keratin 14Tgtransgenic ...
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
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Khavari P A et al., In Oncogene, 2005
... K14-ER:Ras transgenic mice, Jax stock number ...
Genome-scale profiling of histone H3.3 replacement patterns
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Ferguson-Smith Anne C, In PLoS Genetics, 2004
... ], #06–599 (anti-H3K9/K14-acetylation) [30], and Abcam ( ...
Inhibition of mitogen-activated protein kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
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Maggiolini Marcello et al., In Environmental Health Perspectives, 2004
... Briefly cells were incubated with human anti-vimentin (V9) and human anti-cytokeratin 14 (LL001), both from Santa Cruz Biotechnology DBA (Milan, Italy) ...
Hallmarks of 'BRCAness' in sporadic cancers
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Lakhani Sunil R et al., In Breast Cancer Research, 2003
... Briefly, 2 minutes of pressure-cooking at pH 6.0 was used for antigen retrieval with CK14 clone LL002 (1:50) (BioGenex Inc., San Ramon, CA, ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
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Hummler Edith et al., In Nature Communications, 2003
... K14-CAP1/Prss8 transgenic mice.
AP-2α: a regulator of EGF receptor signaling and proliferation in skin epidermis
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Fuchs Elaine et al., In The Journal of Cell Biology, 2002
... K14-Cre transgenic mice were generated as ...
Extracellular calcium sensing and extracellular calcium signaling.
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Li Yi, In PLoS ONE, 2000
... K14-tTA transgenic mice were previously generated ...
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
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Blanpain Cédric et al., In The Journal of Cell Biology, 2000
... ) and K14-CREER (Vasioukhin et al., 1999) transgenic mice were provided by ...
Assessment of cellular profile and lung function with repeated bronchoalveolar lavage in individual mice
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Wang Xiao-Jing et al., In International Journal of Biological Sciences, 1999
... 10min, sections were incubated overnight at 4°C with antibodies against Keratin 5 (1:500 Abcam, Cambridge, MA), K14 (1:1000, Abcam), p63 (1:50 Santa Cruz ...
Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells
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Hanahan Douglas et al., In The Journal of Experimental Medicine, 1999
... K14-HPV16 Transgenic, CD4 Null, and CD8 ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
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Detmar Michael et al., In The Journal of Experimental Medicine, 1997
... After confirmation of specific GFP expression in sites that previously were shown to express K14 (24), the transgenic line with the highest ...
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
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Yeudall Andrew, In PLoS ONE, 1987
... to involucrin (SY5), mouse monoclonal to cornifin (SPRR3), Rabbit polyclonal to GAPDH (abcam, Cambridge, UK), anti-cytokeratin 14 LLOO2 (Cancer Research UK), FOXM1B C-20 (Santa Cruz Biotechnology, Santa Cruz, California, USA), ...
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