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Keratin 10

K10, keratin 10, Endopeptidase K, CK10, cytokeratin 10
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, Involucrin, HAD, K14
Papers using K10 antibodies
Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer
De Buck Jeroen et al., In Proteome Science, 2005
... K10 was grown in Middlebrook 7H9 broth (Becton Dickinson, Oakville, ON, Canada) supplemented ...
Novel ENU-induced eye mutations in the mouse: models for human eye disease.
Agarwal Sudha, In PLoS ONE, 2001
... Rabbit anti-claudin-1 antibody was from Zymed Laboratories and rabbit polyclonal antibodies to keratin 1 and keratin-10 were purchased from Abcam.
Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells.
Karl Mike O., In PLoS ONE, 1988
... anti-γ-tubulin (GTU-88; Sigma-Aldrich, Inc.), anti Aurora kinase B (Abcam), anti Keratin 1,10,11 (Ks 8.60; Abcam), anti Keratin 10 (RKSE60; Abcam), anti-keratin 1 (AF87; Covance), anti-γH2AX ...
The neighbor-joining method: a new method for reconstructing phylogenetic trees
Ortega JM et al., In BMC Genomics, 1986
... Phylogenetic tree of dihydrodipicolinate synthase (K10).
Papers on K10
Distribution of crystalloid fluid changes with the rate of infusion: a population-based study.
Zdolsek et al., Södertälje, Sweden. In Acta Anaesthesiol Scand, Feb 2016
RESULTS: The micro-constants describing distribution (k12 ) and elimination (k10 ) were unchanged when the rate of infusion increased, with half-times of 16 and 26 min, respectively.
Hypoxia leads to abnormal epidermal differentiation via HIF-independent pathways.
Shin et al., South Korea. In Biochem Biophys Res Commun, Feb 2016
We found that hypoxia specifically decreased the protein levels of keratin 1 (K1)/keratin 10 (K10), a representative marker of the epidermal spinous layer in the epidermis.
Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report.
Moriwaki et al., Takatsuki, Japan. In Oncol Lett, Dec 2015
Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.
Recent advances in congenital ichthyoses.
González-Sarmiento et al., Madrid, Spain. In Curr Opin Pediatr, Aug 2015
Mutations in keratin 10 have been identified as the cause of ichthyosis with confetti, a rare form of ichthyosis characterized by severe erythroderma in which healthy spots gradually develop since childhood.
Ileal Intussusception Due to Metastasis from Squamous Cell Carcinoma of the Lung Resected 12 Years Previously.
Makuuchi et al., Tokyo, Japan. In Tokai J Exp Clin Med, 2014
Immunohistochemistry showed that the tumor was CK7 positive, CK20 negative, TTF-1 negative, and CK10 positive.
Ichthyosis with confetti: clinics, molecular genetics and management.
Zambruno et al., Roma, Italy. In Orphanet J Rare Dis, 2014
IWC is due to dominant negative mutations in the KRT10 and KRT1 genes, encoding for keratins 10 and keratin 1, respectively.
Comparative study of cytokeratin and langerin expression in keratinized cystic lesions of the oral and maxillofacial regions.
Sakashita et al., Oral, Kazakhstan. In J Oral Sci, 2014
Seven DMCs, 30 EDMCs, 11 OOCs, and 28 KCOTs were examined immunohistochemically using antibodies against CK10, 13, 14, 16, 17, 19, and langerin.
Proteomic research progress in lymphatic metastases of cancers.
Tang et al., Dalian, China. In Clin Transl Oncol, 2012
Actin, heat-shock proteins (HSPs), annexins, cytokeratin 10 (CK10), CK19, protein gene product 9.5 (PGP9.5)
Benign mucinous metaplasia of the genital mucosa: histomorphological and immunohistochemical features and criteria for differentiation from extramammary Paget disease.
Metze et al., Hamburg, Germany. In Br J Dermatol, 2011
METHODS: Eight biopsy specimens of BMM were stained with haematoxylin and eosin, periodic acid-Schiff and alcian blue, and for cytokeratin (CK) 7, CK10, CK14, CK20, carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), S100, gross cystic disease fluid protein-15 (GCDFP-15), lysozyme and Ki67 and compared with PD.
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia.
Orihuela et al., San Antonio, United States. In Aging Cell, 2011
Aging enhances susceptibility to pneumococcal pneumonia in a K10-dependent manner.
Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis.
Grimberg et al., Köln, Germany. In Br J Dermatol, 2011
mutation analysis in patients with epidermolytic ichthyosis by direct sequencing of KRT1 and KRT10 genes; identified 14 different mutations, of which four have not been published previously
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10.
Lifton et al., New Haven, United States. In Science, 2010
mapping and identifying disease-causing mutations in gene encoding KRT10 in ichthyosis with confetti; high frequency of somatic reversion suggests revertant stem cell clones are under positive selection and/or rate of mitotic recombination is elevated
Molecular pathways of urothelial development and bladder tumorigenesis.
Cordon-Cardo et al., New York City, United States. In Urol Oncol, 2010
Basal and intermediate cells are characterized by a p63 positive phenotype, as well as expression of high molecular weight cytokeratins (CKs), such as CK5, CK10, and CK14.
Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media.
Xiao et al., Omaha, United States. In Pancreas, 2010
Data show that TIMP-1 and cytokeratin-10 were identified as 2 newly synthesized secreted proteins in
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
Waksman et al., France. In Lancet, 2009
Keratin-14 immunostaining was seen in the basal compartment, with keratin 10 present in layers overlying the basal layer.
Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus.
Ramos-e-Silva et al., Rio de Janeiro, Brazil. In J Oral Sci, 2009
Expression was altered in oral lichen planus lesions
Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK).
Sperling et al., Berlin, Germany. In Nat Genet, 1994
R162W was detected in five unrelated families and affects the corresponding residue in the keratin 14 and keratin 10 genes that is also altered in cases of epidermolysis bullosa simplex and generalised epidermolytic hyperkeratosis, respectively.
Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis.
Rosenfeld et al., San Diego, United States. In Science, 1993
A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression.
Cytogenic Behavior of a Knobbed Chromosome 10 in Maize.
Kikudome, In Science, 1961
Unlike maize plants heterozygous the abnormal chromosome 10 (K10) and the normal chromosome 10 (k10), those heterozygous for a knobbed chromosome 10 (K(T)10/k10) do not undergo preferential segregation or "meiotic drive."
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