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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

X-linked Kx blood group

K x, XK, Kx antigen
This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, Xanthine Dehydrogenase, CD45
Papers on K x
Disruption of PHO13 improves ethanol production via the xylose isomerase pathway.
New
Kondo et al., Kōbe, Japan. In Amb Express, 31 Dec 2016
In this study, PHO13 was disrupted in a recombinant strain harboring multiple copies of the xylose isomerase (XI) gene derived from Orpinomyces sp., coupled with overexpression of the endogenous xylulokinase (XK) gene and disruption of GRE3, which encodes aldose reductase.
The human Kell blood group binds the erythroid 4.1R protein: new insights into the 4.1R-dependent red cell membrane complex.
New
Le Van Kim et al., Paris, France. In Br J Haematol, Dec 2015
We also observed that 4.1R deficiency is associated with a reduction of XK and DARC (also termed ACKR1) proteins, the absence of the glycosylated form of the urea transporter B and a slight decrease of band 3. The functional alteration of the 4.1(-) HE erythrocyte membranes was also determined by measuring various transport activities.
Fixation of Metacarpal Shaft Fractures: Biomechanical Comparison of Intramedullary Nail Crossed K-Wires and Plate-Screw Constructs.
New
Litsky et al., Columbus, United States. In Orthop Surg, Aug 2015
It was postulated that plates would have a significantly higher (P < 0.05) load to failure than crossed K(XK)-wires and that intramedullary metacarpal nails (IMNs) and XK-wires would have equivalent load to failure.
Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms.
New
Zhou et al., Kanazawa, Japan. In Plos Genet, Jun 2015
In addition, CED-8, the C. elegans homolog of mammalian Xk-related protein 8 also makes a contribution to necrotic cell-removal at the first larval stage.
Neurodegeneration in the elderly - When the blood type matters: An overview of the McLeod syndrome with focus on hematological features.
Review
New
Jung et al., Zürich, Switzerland. In Transfus Apher Sci, Jun 2015
Hematological abnormalities such as blood group abnormalities in Kell- and XK blood group system, formation of anti-public red blood cell alloantibodies, acanthocytosis and elevated creatinine phosphokinase may precede clinical disease manifestation for decades and provide tools for early diagnosis.
Genome-wide DNA methylation analysis of Haloferax volcanii H26 and identification of DNA methyltransferase related PD-(D/E)XK nuclease family protein HVO_A0006.
Papke et al., United States. In Front Microbiol, 2014
However, protein domain architecture analysis and amino acid alignments revealed that HVO_A0006 is homologous only to the N-terminal endonuclease region of Type IIG RM proteins and contains a PD-(D/E)XK nuclease motif, suggesting that HVO_A0006 is a PD-(D/E)XK nuclease family protein.
Kell and Kx blood group systems.
Review
Denomme, Milwaukee, United States. In Immunohematology, 2014
The Kell and Kx blood group systems are expressed as covalently linked molecules on red blood cells (RBCs).
Draft Genome Sequence of Bacillus amyloliquefaciens XK-4-1, a Plant Growth-Promoting Endophyte with Antifungal Activity.
Zhou et al., Guelph, Canada. In Genome Announc, 2014
Here, we report the draft genome sequence of a bacterial plant-growth-promoting endophyte, Bacillus amyloliquefaciens XK-4-1, which consists of one circular chromosome of 3,941,805 bp with 3,702 coding sequences (CDSs).
Abnormal red cell features associated with hereditary neurodegenerative disorders: the neuroacanthocytosis syndromes.
Review
Mohandas et al., New York City, United States. In Curr Opin Hematol, 2014
Similarly, in MLS, the absence of XK-protein, which is associated with the spectrin-actin-4.1 junctional complex, is associated with an abnormal membrane protein phosphorylation state, with destabilization of the membrane skeletal network resulting in generation of acanthocytes.
Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
Impact
Nagata et al., Kyoto, Japan. In Science, 2013
We show that the Xk-family protein Xkr8 mediates PtdSer exposure in response to apoptotic stimuli.
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease.
Impact
Prokisch et al., Bonn, Germany. In Nat Genet, 2013
C20orf72, hereafter MGME1 (mitochondrial genome maintenance exonuclease 1), encodes a mitochondrial RecB-type exonuclease belonging to the PD-(D/E)XK nuclease superfamily.
The first case report of McLeod syndrome in a Chinese patient.
Review
Ng et al., Hong Kong, Hong Kong. In Bmj Case Rep, 2012
We report the first case of McLeod syndrome (MLS) in a 47-year-old Chinese man who presented with progressive limb weakness, chorea of feet, red blood cell acanthocytosis, absence of Kx red blood cell antigen and weak expression of Kell antigens.
Restriction endonucleases: natural and directed evolution.
Review
Sharma et al., Chandīgarh, India. In Appl Microbiol Biotechnol, 2012
PD-(D/E)XK nucleases, initially represented by only type II REs, now comprise a large and extremely diverse superfamily of proteins and, although sharing a structurally conserved core, typically display little or no detectable sequence similarity except for the active site motifs.
Two McLeod patients with novel mutations in XK.
GeneRIF
Walker et al., New York City, United States. In J Neurol Sci, 2011
Novel XK protein mutations are reported in two patients who exhibit typical clinical characteristics of McLeod syndrome.
Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia.
GeneRIF
Sano et al., Kagoshima, Japan. In Neurosci Res, 2011
This study identified one non-synonymous and one intron variant in mood disorder and schizophrenia subjects, respectively, in XK.
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.
Impact
Liu et al., Beijing, China. In Nature, 2009
The PA(N) structure has an alpha/beta architecture and reveals a bound magnesium ion coordinated by a motif similar to the (P)DX(N)(D/E)XK motif characteristic of many endonucleases.
Phenotypic variability of a distinct deletion in McLeod syndrome.
GeneRIF
Jung et al., Santiago, Chile. In Mov Disord, 2007
Sequence analysis demonstrated a 5 bp deletion in exon 2 of the XK gene in McLeod syndrome.
The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system.
GeneRIF
Ouimet et al., Paris, France. In Brain Res, 2007
In human cortex, the results show expression of XK in cortical neurons with an apparent cytoplasmic localization.
Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.
Impact
Monaco et al., Oxford, United Kingdom. In Cell, 1994
The mRNA expression pattern of one of them, designated as XK, correlates closely to the McLeod phenotype.
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