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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Immunoglobulin kappa constant

K m, IGKC
Top mentioned proteins: V-I, HAD, iMpact, erbB-2, POLYMERASE
Papers on K m
Equine immunoglobulins and organization of immunoglobulin genes.
Review
New
Czerny et al., Göttingen, Germany. In Dev Comp Immunol, Dec 2015
The kappa light chain contains 60 IGKV, 5 IGKJ and 1 IGKC, whereas there are 144 IGLV, 7 IGLJ, and 7 IGLC for the lambda light chain, which is expressed predominantly in horses.
Branched-chain in situ hybridization for κ and λ light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples.
New
Deshpande et al., Boston, United States. In Cancer Cytopathol, Dec 2015
This study examined a series of cytology specimens and explored the ability of a branched-chain RNA (bRNA) ISH assay for immunoglobulin κ constant (IGKC) and immunoglobulin λ constant (IGLC) to detect a clonal population of B lymphocytes.
An overview of the lagomorph immune system and its genetic diversity.
Review
New
Esteves et al., Porto, Portugal. In Immunogenetics, Oct 2015
Studies of IGHV and IGKC genes expressed in leporids are two of the few examples of trans-species polymorphism observed outside of the major histocompatibility complex.
NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation.
New
Vilches et al., Madrid, Spain. In J Immunol, Sep 2015
Of potential relevance are a FCGR3A dimorphism resulting in CD16A-valine/phenylalanine-158 allotypes with different IgG affinity, variations conditioning NK cell expression of CD32B or CD32C, and IgG1 H chain (IGHG1) and kappa-chain (IGKC) polymorphisms determining allotypes designated G1m and Km.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
New
Impact
Loibl et al., Rostock, Germany. In J Clin Oncol, Apr 2015
mRNA expression of immune-activating (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors.
Investigation of serum proteome alterations in human endometriosis.
New
Chaudhury et al., Kharagpur, India. In J Proteomics, Mar 2015
Western blotting validation in a separate cohort of patients revealed that haptoglobin (HP), Ig kappa chain C region (IGKC), alpha-1B-glycoprotein (A1BG) can be considered effective serum protein markers for the diagnosis of Stage II, III and IV endometriosis.
Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA-Seq method.
Oczkowicz et al., Bielsko-Biała, Poland. In Anim Genet, 2014
In the Pietrain breed, only seven genes were over-expressed (CISH, SPP1, TUBA8, ATP6V1C2, IGKC, predicted LOC100510960 and LOC100626400), and they play important roles in, for example, negative regulation of apoptosis, immune response, cell-cell signaling, cell growth and migration as well as the metabolic process.
IGKC and FcγR genotypes and humoral immunity to HER2 in breast cancer.
Tsugane et al., Charleston, United States. In Immunobiology, 2014
The primary aim of the present investigation was to determine whether the genetic variants of IGKC, KM (κ marker) allotypes, are risk factors for breast cancer, and whether they influence the magnitude of humoral immunity to epidermal growth factor receptor 2 (HER2), which is overexpressed in 25-30% of breast cancer patients and is associated with poor prognosis.
The plasma cell signature in autoimmune disease.
Ranade et al., Gaithersburg, United States. In Arthritis Rheumatol, 2014
Whole-genome microarray analysis of sorted cellular fractions identified a panel of genes, IGHA1, IGJ, IGKC, IGKV4-1, and TNFRSF17, expressed predominantly in PCs.
The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.
Micke et al., Dortmund, Germany. In Cancer Lett, 2013
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer.
Immune responses to cancer: are they potential biomarkers of prognosis?
Whiteside, Pittsburgh, United States. In Front Oncol, 2012
Among them, the B-cell signature, as exemplified by expression of the immunoglobulin G kappa chain (IGKC) in tumor-infiltrating lymphocytes (TIL), has been validated as a biomarker of response to adjuvant therapy and better survival in patients with breast carcinoma and several other types of human solid tumors.
A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors.
GeneRIF
Hengstler et al., Mainz, Germany. In Clin Cancer Res, 2012
The findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer.
Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion.
Murtaugh et al., Saint Paul, United States. In Immunogenetics, 2012
The porcine IGK variable locus is 27.9 kb upstream of five IG kappa J genes (IGKJ) which are separated from a single constant gene (IGKC) by 2.8 kb.
[DNA microarray analysis in nerve biopsies of patients with vasculitic neuropathy].
Review
Renaud et al., Basel, Switzerland. In Rev Neurol (paris), 2011
Genes upregulated in VAS include IGLJ3, IGHG3, IGKC, and IGL, which all function in B-cell selection or antigen recognition of B cells.
Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
Schmidt et al., Mainz, Germany. In Plos One, 2011
We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients.
The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation.
GeneRIF
Walker et al., Little Rock, United States. In Mod Pathol, 2011
Light chain proximal tubulopathy without crystal formation, despite being rarely described in the literature, is over three times more common than light chain proximal tubulopathy with crystal formation in our series.
Higher serum levels of free ĸ plus λ immunoglobulin light chains ameliorate survival of hemodialysis patients.
GeneRIF
Tepel et al., Berlin, Germany. In Kidney Blood Press Res, 2010
In survivors of chronic kidney failure, median serum levels of free kappa plus lambda immunoglobulin light chains are significantly higher compared with nonsurvivors.
Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils.
GeneRIF
Trinkaus-Randall et al., Boston, United States. In J Biol Chem, 2010
Glycosaminoglycan sulfation enhanced the formation of immunoglobulin light chain amyloid oligomers and fibrils.
Differential expression of immunoglobulin kappa chain constant region in human abdominal aortic aneurysm.
GeneRIF
Joh et al., Seoul, South Korea. In J Surg Res, 2005
Differentially expressed Ig kappa-C gene only in abdominal aortic aneurysm(AAA) is candidate gene that may play pivotal role in pathogenesis of AAA formation.
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