Novel endogenous angiogenesis inhibitors and their therapeutic potential.
Singapore, Singapore. In Acta Pharmacol Sin, Oct 2015
In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA.
Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Wuxi, China. In Biochem Biophys Res Commun, Oct 2015
In our previous study, we have found that the deficiency of osteoblastic Arl6ip5 (ADP-ribosylation-like factor 6 interacting protein 5), an endoplasmic reticulum (ER)-localized protein belonging to the prenylated rab-acceptor-family, enhanced osteoclastogenesis by increasing RANKL transcription in an ER stress dependent signaling.
Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.
Kyoto, Japan. In Biochemistry, Jun 2015
To identify the binding site of amilorides in bovine complex I, we synthesized two photoreactive amilorides (PRA1 and PRA2), which have a photoreactive azido (-N3) group and terminal alkyne (-C≡CH) group at the opposite ends of the molecules, respectively, and conducted photoaffinity labeling with bovine heart submitochondrial particles.
Transport of amino acids in the kidney.
In Compr Physiol, 2014
Interacting proteins include cell surface antigens (CD98), endoplasmic reticulum proteins (GTRAP3-18 or 41), or enzymes (ACE2 and aminopeptidase N).
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.
Nanjing, China. In Cell Death Dis, 2013
Recently, we demonstrated that the reduced expression of base excision repair protein XRCC1 and its upstream regulator JWA in gastric cancerous tissues correlated with a significant survival benefit of adjuvant first-line platinum-based chemotherapy as well as XRCC1 playing an important role in the DNA repair of cisplatin-resistant gastric cancer cells.
Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer.
Nanjing, China. In Clin Cancer Res, 2012
JWA and XRCC1 protein levels were downregulated in gastric cancer lesions compared with adjacent noncancerous tissues;JWA and XRCC1 protein expressions in tumor are candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy in resectable gastric carcinoma