Integrated regulation of motor-driven organelle transport by scaffolding proteins.
Philadelphia, United States. In Trends Cell Biol, Oct 2014
Recent progress demonstrates that organelle-associated scaffolding proteins, including Milton/TRAKs (trafficking kinesin-binding protein), JIP1, JIP3 (JNK-interacting proteins), huntingtin, and Hook1, interact with molecular motors to coordinate activity and sustain unidirectional transport.
JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.
Kanazawa, Japan. In Genes Cells, Sep 2014
Here, we investigated the functions of two binding partners of active ARF6, c-Jun NH2 -terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) and JNK-associated leucine zipper protein (JLP), by gene knockout and rescue experiments in mouse embryonic fibroblasts.