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Junctophilin 2

JP2, junctophilin-2
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JP1, CAN, HAD, POLYMERASE, OUT
Papers using JP2 antibodies
Targeting phosphoinositide 3-kinase: moving towards therapy.
Supplier
Bratton Shawn B., In PLoS ONE, 2007
... Pan-p85 antibody was from Millipore; antibodies for Akt and JP-2 (for western blotting) were from Santa Cruz Biotechnology.
Papers on JP2
The JP2 genotype of Aggregatibacter actinomycetemcomitans and marginal periodontitis in the mixed dentition.
New
Haubek et al., Århus, Denmark. In J Clin Periodontol, Jan 2016
AIM: To perform a cross-sectional study on the carrier frequency of JP2 and non-JP2 genotypes of A. actinomycetemcomitans in Moroccan schoolchildren and relate the presence of these genotypes to the periodontal status in the mixed dentition.
Aggregatibacter actinomycetemcomitans serotypes and DGGE subtypes in Thai adults with chronic periodontitis.
New
Teanpaisan et al., Hat Yai, Thailand. In Arch Oral Biol, Dec 2015
A JP2 like strain but serotyped as c was isolated from two patients, and another two strains showed an 886bp insertion on the ltx promoter of their A. actinomycetemcomitans isolates.
Virulence of Aggregatibacter actinomycetemcomitans serotypes and DGGE subtypes isolated from chronic adult periodontitis in Thailand.
New
Teanpaisan et al., Hat Yai, Thailand. In Anaerobe, Dec 2015
Two strains with a JP2-like ltx gene with a deletion of 530 bp in the promoter region, serotyped as c, showed virulence of similar magnitude to the JP2 strain.
Characterization of A. actinomycetemcomitans strains in subgingival samples from periodontitis subjects in Morocco.
New
Herrera et al., Madrid, Spain. In Clin Oral Investig, Dec 2015
OBJECTIVE: Aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (JP2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis.
Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.
New
Song et al., London, Canada. In J Biol Chem, Aug 2015
Junctophilin-2 (JP2), a membrane-binding protein that provides a structural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise Ca(2+)-induced Ca(2+) release during excitation-contraction coupling in cardiomyocytes.
Medicinal effect and its JP2/RyR2-based mechanism of Smilax glabra flavonoids on angiotensin II-induced hypertrophy model of cardiomyocytes.
New
Chen et al., Hangzhou, China. In J Ethnopharmacol, Aug 2015
Such effect could be mediated by the modulation of intracellular Ca(2+) flux in myocardial cells, in which junctophilin-2 (JP2) and ryanodine receptor 2 (RyR2) play an important role.
A. actinomycetemcomitans profile and red complex bacterial species of an Afro-Brazilian community: A comparative study.
New
Cortelli et al., Taubaté, Brazil. In Arch Oral Biol, May 2015
The secondary aim was to compare the distribution of both Aggregatibacter actinomycetemcomitans serotype b and its JP2 strains among participants who harboured this bacterial species.
Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes.
New
Soeller et al., Auckland, New Zealand. In J Mol Cell Cardiol, Mar 2015
Dual-colour dSTORM revealed high co-localisation between the cardiac junctional protein junctophilin-2 (JPH2) and RyR clusters that confirmed that the majority of the RyR clusters observed are dyadic.
Subgingival microbial profiles of Sudanese patients with aggressive periodontitis.
Bolstad et al., Bergen, Norway. In J Periodontal Res, 2015
The purpose of the present study was to map the subgingival microbiota as well as explore the presence of A. actinomycetemcomitans and the JP2 clone in a group of Sudanese individuals with AgP, using different analytical methods.
Aggressive Periodontitis: microbes and host response, who to blame?
Review
Nibali, London, United Kingdom. In Virulence, 2014
Ensuing years of research have led to linkage analysis identification of specific genetic defects responsible for AgP in some families and to the finding that subgingival detection of A. actinomycet-emcomitans JP2 clone is a predictive factor for disease onset and progression.
Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.
Review
Wehrens et al., Houston, United States. In Cardiovasc Res, 2014
In a little over a decade, junctophilin-2 (JPH2) has become recognized as a cardiac structural protein critical in forming junctional membrane complexes (JMCs), which are subcellular domains essential for excitation-contraction coupling within the heart.
Microbiology of aggressive periodontitis.
Review
Müller et al., In Periodontol 2000, 2014
Its specific JP2 clone, however, shows properties of a true exogenous pathogen and has an important role in the development of aggressive periodontitis in certain populations.
Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis.
Review
Johansson et al., Århus, Denmark. In J Oral Microbiol, 2013
In the middle of the 1990s, a specific JP2 clone of A. actinomycetemcomitans, belonging to the cluster of serotype b strains of A. actinomycetemcomitans and having a number of other characteristics, was found to be strongly associated with aggressive forms of periodontitis, particularly in North Africa.
Microarchitecture of the dyad.
Review
Moore et al., Vancouver, Canada. In Cardiovasc Res, 2013
The essential role of proteins, such as junctophilin-2, calsequestrin, triadin, and junctin that maintain both the functional and structural integrity of the dyad have recently been elucidated giving a new mechanistic understanding of heart diseases, such as arrhythmias, hypertension, failure, and sudden cardiac death.
Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells.
GeneRIF
Lou et al., Hangzhou, China. In J Cell Biochem, 2012
Reducing JP2 expression in ESC-CMs resulted in impaired mitochondrial status due to either abnormal cellular Ca(2+) homeostasis or disturbing of juxtaposition.
Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.
GeneRIF
Lee et al., Seoul, South Korea. In J Biol Chem, 2012
Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.
Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes.
GeneRIF
Soeller et al., In Biophys J, 2012
JPH2 is dispersed throughout RyR clusters and that the packing of JPH2 into junctions and the assembly of RyR clusters are tightly linked
Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle.
GeneRIF
Sorrentino et al., Siena, Italy. In J Biol Chem, 2012
JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
GeneRIF
Wehrens et al., Houston, United States. In Circulation, 2011
Loss-of-function mutations in JPH2 leads to cardiac-specific JPH2 deficiency and results in impaired cardiac contractility, causing heart failure and increased mortality.
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study.
Impact
Kilian et al., Århus, Denmark. In Lancet, 2008
Although the cause of periodontitis in general remains elusive, a particular clone (JP2) of the gram-negative rod Aggregatibacter (Actinobacillus) actinomycetemcomitans is considered a possible aetiological agent of the aggressive form in adolescents living in or originating from north and west Africa, where the disease is highly prevalent.
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