Ca²⁺ microdomains organized by junctophilins.
Kyoto, Japan. In Cell Calcium, Oct 2015
Junctophilin subtypes contribute to the formation and maintenance of JMCs by serving as a physical bridge between the plasma membrane and ER/SR membrane in different cell types.
Activity attenuates skeletal muscle fiber damage after ischemia and reperfusion.
Houston, United States. In Muscle Nerve, Oct 2015
Sedentary and active rats had a similar decline in neural-evoked (∼ 99%) and directly stimulated (∼ 70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural-evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar.
Microarchitecture of the dyad.
Vancouver, Canada. In Cardiovasc Res, 2013
The essential role of proteins, such as junctophilin-2, calsequestrin, triadin, and junctin that maintain both the functional and structural integrity of the dyad have recently been elucidated giving a new mechanistic understanding of heart diseases, such as arrhythmias, hypertension, failure, and sudden cardiac death.
Coexpression of junctophilin type 3 and type 4 in brain.
Sendai, Japan. In Brain Res Mol Brain Res, 2003
We report a novel Junctophilin subtype, JP-4, encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 shares characteristic structural features with other JP subtypes, and is found in the brain.