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Mitogen-activated protein kinase 8

JNK, c-Jun N-terminal kinase, JNK1
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, AP-1, MAPK, V1a, ERK
Papers using JNK antibodies
LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways.
Ulasov Ilya, In PLoS ONE, 2009
... The polyclonal antibodies against SAPK/JNK and pSAPK/JNK were obtained from Cell Signaling.
ERbeta expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis
Huang Chih-Yang et al., In Journal of Biomedical Science, 2009
... The LY294002 (PI3K inhibitor), U0126 (MEK1/2 inhibitor), SB203680 (p38 MAPK inhibitor), SP600125 (JNK inhibitor), and ER antagonist ICI 182,780 (ICI) were purchased from TOCRIS (Ellisville, Missouri, USA) ...
Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.
Lobaccaro Jean-Marc A., In PLoS ONE, 2009
... against p-AKT (D9E), cleaved caspase 8 (Asp391), p-p38 (3D7), Erk1/2 (C-16), p-Erk1/2 (D13.14.4E), p-JNK (81E11), and JNK (2C6) were from Cell Signaling Technology ...
Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease.
Feany Mel, In PLoS ONE, 2009
... The mouse anti-phosphorylated Akt (Ser473) antibody, rabbit anti-phosphorylated SAPK/JNK, and rabbit anti-Akt and anti-SAPK/JNK antibodies were obtained from Cell Signaling Technology (Beverly, MA) ...
Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate
Jiang Yangfu et al., In Breast Cancer Research : BCR, 2008
... The phosphorylated JNK antibody and JNK inhibitor SP600125 were provided by Cell Signaling (Beverly, MA, USA) ...
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Papers on JNK
c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.
Kim et al., Suwŏn, South Korea. In Phytother Res, Feb 2016
Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells.
Formononetin upregulates nitric oxide synthase in arterial endothelium through estrogen receptors and MAPK pathways.
Cao et al., Xi'an, China. In J Pharm Pharmacol, Feb 2016
ICI 182780, U0126 (an ERK1/2 inhibitor) and SP600125 (a JNK inhibitor) prevented the increases in arterial relaxation and eNOS levels.
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
These include SOCS3, tyrosine phosphatase PTP1B, and inflammatory signaling pathways such as IKK-NFκB and JNK signaling, and ER stress-mitochondrial signaling.
Cylindromatosis-A Protective Molecule against Liver Diseases.
Massoumi et al., Regensburg, Germany. In Med Res Rev, Feb 2016
The function of CYLD is via deubiquitination of specific substrates in different signaling pathways including NF-κB, Notch, and JNK.
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
Zhu et al., Lanzhou, China. In Mol Med Report, Feb 2016
Furthermore, analysis of the signaling events indicated that netrin‑1‑mediated protection against cardiac hypertrophy was attributed to interruption of the activation of mitogen‑activated protein kinase kinase (MEK) kinase‑1 (K1)‑dependent MEK‑extracellular signal‑regulated protein kinase 1/2 (ERK1/2) and c‑Jun N‑terminal kinase 1/2 (JNK1/2).
Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics.
Mueller et al., Bern, Switzerland. In Hum Reprod Update, Feb 2016
RESULTS: The current literature on intracellular kinases activated by the endometriotic environment can be summarized into three main pathways that could be targeted for treatments: the canonical IKKβ/NFκB pathway, the MAPK pathways (ERK1/2, p38 and JNK) and the PI3K/AKT/mTOR pathway.
FGF signalling regulates bone growth through autophagy.
Settembre et al., Pozzuoli, Italy. In Nature, Jan 2016
Surprisingly, post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1.
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions.
Okazaki et al., Hirakata, Japan. In J Clin Med, Dec 2015
As the TGF-β receptors, c-Jun N-terminal kinase and cyclin-dependent kinase, differentially phosphorylate Smad2/3, we have generated numerous antibodies against linker (L) and C-terminal (C) phosphorylation sites in Smad2/3 and identified four types of phosphorylated forms: cytostatic COOH-terminally-phosphorylated Smad3 (pSmad3C), mitogenic pSmad3L (Ser-213) signaling, fibrogenic pSmad2L (Ser-245/250/255)/C signaling and migratory pSmad2/3L (Thr-220/179)/C signaling.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
Tβ4 peptide inhibited the effects of H2O2 on the activation of ERK and JNK MAPK, and NF-κB in PDLCs.
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.
Linker et al., Bochum, Germany. In Immunity, Nov 2015
Alternatively, dietary short-chain FAs (SCFAs) expanded gut T regulatory (Treg) cells by suppression of the JNK1 and p38 pathway.
Regulation of mitochondrial morphology and function by stearoylation of TFR1.
Teleman et al., Heidelberg, Germany. In Nature, Oct 2015
We elucidate a signalling pathway whereby C18:0 stearoylates TFR1, thereby inhibiting its activation of JNK signalling.
Niche appropriation by Drosophila intestinal stem cell tumours.
Edgar et al., Seattle, United States. In Nat Cell Biol, Sep 2015
This loss of epithelial integrity induces JNK and Yki/YAP activity in enterocytes and, consequently, their expression of stress-dependent cytokines (Upd2, Upd3).
The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.
Léopold et al., Nice, France. In Nature, Jul 2015
JNK signalling is known to play an important part in driving the malignant progression of many epithelial tumours, although the link between loss of polarity and JNK signalling remains elusive.
Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway.
Jiang et al., Shenyang, China. In Evid Based Complement Alternat Med, 2014
Moreover, bufalin increased the phosphorylation of JNK and p38-MAPK in CAPAN-2 and CAL-27 cells, and blocking the JNK/p38-MAPK pathway using the JNK inhibitor SP600125 or the p38-MAPK inhibitor SB203580 reversed bufalin-induced hTERT downregulation.
RASSF6; the Putative Tumor Suppressor of the RASSF Family.
Hata et al., Tokyo, Japan. In Cancers (basel), 2014
RASSF6 regulates apoptosis and cell cycle through these protein-protein interactions, and is implicated in the NF-κB and JNK signaling pathways.
New insights into the mechanism of JNK1 inhibition by glutathione transferase P1-1.
Caccuri et al., Roma, Italy. In Biochemistry, 2012
adduct formed by GSH and the strong GSTP1-1 inhibitor NBDHEX abolishes the interaction between GSTP1-1 and JNK1alpha2.
Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells.
Rodriguez et al., Oviedo, Spain. In J Neurosci Res, 2012
the boost in oxidants from MPP(+) treatment in neuronal PC12 is modulating both survival (AKT/mTOR) and death (JNK) pathways, which are the perpetrators of an autophagic cell death.
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Davis et al., Worcester, United States. In Proc Natl Acad Sci U S A, 2012
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.
Lo et al., Boston, United States. In J Neurosci, 2012
data provide initial proof-of-concept that the neuronal death target JNK may also participate in endogenous processes of neurovascular remodeling and recovery after cerebral ischemia.
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.
Talianidis et al., Greece. In Cancer Cell, 2012
Results show that, in the liver, CYLD acts as an important regulator of hepatocyte homeostasis, protecting cells from spontaneous apoptosis by preventing uncontrolled TAK1 and JNK activation.
More papers using JNK antibodies
Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice
Luo Jia et al., In Molecular Cancer, 2008
... Anti-active JNK antibody was obtained from Promega Corporation (Madison, WI) ...
Lost in translation: an assessment and perspective for computational microRNA target identification.
Choi Sangdun, In PLoS ONE, 2008
... The specific JNK inhibitor SP600125 was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Migliaccio Antimo, In PLoS ONE, 2008
... rabbit anti S6 kinase (Sigma, S4047), monoclonal mouse anti phospho-Erk1/2 (Sigma, 8159), polyclonal rabbit anti JNK (Cell Signaling, 9252), polyclonal rabbit anti ...
The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion.
Zernecke Alma, In PLoS ONE, 2008
... Antibodies to phosphorylated forms of JNK1/2 and to total JNK1/2 were from Cell Signaling, Beverly, MA ...
Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury
Combs Colin K et al., In Journal of Neuroinflammation, 2007
... Anti-phospho-p38, anti-p38, anti-phospho-JNK, anti-JNK were from Cell Signaling (Beverly, MA) ...
Analyzing real-time PCR data by the comparative C(T) method.
Mossman Karen L., In PLoS ONE, 2007
... STAT1, STAT1 pY701 (BD Transduction Technology), JNK 1 & 2 [pT183/pY185] antibody was purchased from Biosource, total JNK, total p38α and p38α [pT180/pY182] antibodies were purchased from Cell Signaling, and β-catenin antibody was ...
Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.
Nishida Teruo et al., In Molecular Vision, 2007
... to total or phosphorylated forms of extracellular signal–regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), JNK, or I kappa B-alpha (IκB-α) were obtained from Cell Signaling (Beverly, MA), and rabbit ...
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.
Sanchis Daniel, In PLoS ONE, 2007
... antibody, anti-mouse monoclonal IgG peroxidase conjugate antibody, anti-β-actin polyclonal antibody, anti-ERK, p-ERK, p-p38, p38, JNK, p-JNK antibodies, and anti-mouse GHSR antibody were purchased from Santa Cruz Biotechnology Inc (Waltham, MA, USA) ...
Unrestrictive identification of multiple post-translational modifications from tandem mass spectrometry using an error-tolerant algorithm based on an extended sequence tag approach
Srinivasula Srinivasa M., In PLoS ONE, 2007
... BD Biosciences (KY, USA), anti-ubiquitin antibody from Chemicon International (CA, USA), anti-PARP and anti-JNK and anti-phospho-JNK (Thr183/Tyr185) from Santa Cruz Biotechnology (CA, USA), and anti-Akt ...
Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-κB-dependent pathway.
Bandeira de Melo Christianne, In PLoS ONE, 2007
... Rabbit monoclonal antibodies against COX-2, IKKα, IκBα, and JNK1 were purchased from Epitomics Inc ...
The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun
Yarwood Stephen J. et al., In Cellular Signalling, 2006
... Primary antibodies to anti-total ERK, anti-phospho-ERK (Thr202/Tyr204), anti-total c-Jun, anti-phospho-c-Jun (Ser63), anti-total JNK, anti-phospho-JNK, pan-PKC and anti-β‐tubulin were purchased from New England Biolabs.
Study of matrix metalloproteinases and their inhibitors in breast cancer
Tari Ana M et al., In Breast Cancer Research : BCR, 2006
... )-c-Jun N-terminal kinase (JNK), and JNK antibodies were purchased from Cell Signaling (Beverly, MA, USA).
4-Hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G.
Hartl Dominik, In PLoS ONE, 2006
... The rabbit polyclonal anti-phospho-SAPK/JNK and anti-SAPK/JNK antibodies were obtained from Cell Signaling Technology (Danvers, MA) ...
Creating self-illuminating quantum dot conjugates.
Frangogiannis Nikolaos, In PLoS ONE, 2005
... Polyclonal antibodies to ERK, phospho-ERK, p38MAPK, phospho-p38MAPK, JNK, and phospho-JNK were obtained from Cell Signaling (Danvers, MA) ...
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing.
Connon Che John, In PLoS ONE, 2005
... MKK6 and total p65 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA); Antibodies for phospho-JNK (Thr-183, Tyr-185) (Promega, Madison, WI), F4/80 (ABcam Inc, Cambridge, MA), IκBα ...
The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.
Zhang Lin, In PLoS ONE, 2005
... Polyclonal anti-survivin and STAT3, MEK1, AKT1, p38 MAPK, SAPK/JNK antibodies were from Cell Signaling (Danvers, MA) ...
Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9
Wang Yan-ling et al., In Reproductive Biology and Endocrinology : RB&E, 2005
... The antibodies specific against β-actin, phospho-ERK1/2, phospho-JNK, total-ERK1/2 and total-JNK were purchased from Cell Signaling Technology, Inc ...
Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets
Le Yingying et al., In Journal of Neuroinflammation, 2005
... Antibodies against both phosphorylated and unphosphorylated extracellular signal-regulated kinases (ERK1/2), p38, c-jun N-terminal kinase (JNK) were obtained from Cell Signaling Technology (New England Biolabs, ...
ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration
Tanoue Akito et al., In The Journal of Cell Biology, 2004
... ) JNK (Cell Signaling Technology); antiphosphorylated Tyr (pTyr) ...
Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals
Hung Chi-Feng et al., In Molecular Vision, 2004
... Primary antibodies anti-p38 and anti-phospho- c-jun-NH2 terminal kinase (JNK) were purchased from Cell Signaling Technology (Beverly, MA); anti-JNK, ...
Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis
Eckert Richard L., In PLoS ONE, 2004
... ), anti-Nuclear Factor-erythroid 2 (Nrf2), anti-ERK1/2, anti-p38, anti-c-jun N-terminal kinase (JNK) and blotto (non fat dry milk) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... (ab29379; Abcam, Cambridge, UK), phospho-SMAD3 (ab52903; Abcam), IKKβ (2370; Cell Signaling), phospho-IKKα/β (2681; Cell Signaling), JNK-1/2 (9252; Cell Signaling), phospho-JNK-1/2 (4668; Cell Signaling), ...
Intracellularly expressed TLR3s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
Yokochi Takashi et al., In BMC Cancer, 2003
... Antibody to p38, c-Jun N-terminal kinase (JNK1/2), IκB, IRF-3, and phosphorylated form of p38 and JNK1/2 were purchased from Cell Signaling Technology, Beverly, MA, USA ...
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
Ellis L M et al., In British Journal of Cancer, 2003
... Cell Signaling Technology, Beverly, MA, USA), polyclonal rabbit anti-phospho-Akt (Ser473; Cell Signaling Technology), polyclonal rabbit anti-JNK (Thr183/Tyr185; Cell Signaling Technology), polyclonal rabbit anti-MAPK ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... M, Cell Signaling Technology, Danvers, MA) and the JNK inhibitor SP600125 (10 μM, Cell Signaling) were added to the ...
A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression
Ramji Dipak P. et al., In Cellular Signalling, 2003
... The non-radioactive AKT and JNK activity kits were from Cell Signaling Technology, the inhibitors were ...
Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase
Li Zhi-Chao et al., In Mediators of Inflammation, 2002
... Antibodies to ERK1/2 and phospho-ERK1/2, JNK and phospho-JNK were from Cell Signaling (Beverly, MA, USA) ...
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.
Zanger Ulrich, In PLoS ONE, 2002
... First-Strand Synthesis System from Invitrogen; fetal bovine serum from Atlanta biological; anti-phospho-SAPK/JNK (Thr183/Thy185) antibody and anti-SAPK/JNK (56G8) antibody from Cell Signaling Technology; GADD45B (N-19) antibody ...
A differential role for the mitogen activated protein kinases in lipopolysaccharide signaling: The MEK/ERK pathway is not essential for nitric oxide and interleukin 1β production
Syahida Ahmad et al., In International Journal of Molecular Sciences, 2001
... Rabbit polyclonal against human JNK1/2, pJNK1/2 were purchased from Cell Signaling Inc ...
Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
Zhang Yumin et al., In Journal of Neuroinflammation, 2001
... against phosphorylated and total p38, extracellular signal regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) were purchased from Cell Signaling Technology (Danvers, MA) ...
Effect of intravenous bisphosphonates on release of basic fibroblast growth factor in serum of patients with cancer-associated hypercalcemia
Body J-J et al., In British Journal of Cancer, 2001
... The phosphospecific antibodies anti-ERK1/2 MAPK, -p38 MAPK and -JNK were purchased from New England Biolabs Inc ...
Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction.
Lafrenie Robert, In PLoS ONE, 2001
... Antibodies against Bcl-2, Bax, JNK 1/2 were purchased from BioVision Research Products (Mountain View, ...
Oxidized LDL in carotid plaques and plasma associates with plaque instability
Zou Ming-Hui et al., In Diabetes, 2001
... -terminal kinase (JNK), and 3-nitrotryosine were obtained from Cell Signaling Biotechnology (Danvers, MA) ...
Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells
Rivera Juan et al., In The Journal of Experimental Medicine, 2001
... Rabbit antibodies to ERK2, JNK1, and p38MAPK were from Santa Cruz Biotechnology, Inc., mouse anti-phospho-ERK2, rabbit ...
Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes
Lupiáñez José A et al., In BMC Cancer, 2000
... Primary antibodies, anti-caspase-3, -9 and anti-JNK were from Cell Signaling Technology (USA) ...
Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation
Chen Cheng-Nan et al., In Journal of Biomedical Science, 2000
... Mouse monoclonal antibodies (mAB) against extracellular signal-regulated kinase 2 (ERK2), JNK1, phospho-ERK, and phospho-JNK were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
c-Jun is a negative regulator of myelination
Jessen Kristján R. et al., In The Journal of Cell Biology, 2000
... The JNK inhibitor SP600125 (Bennett et al., 2001) was obtained from BIOMOL International, L.P ...
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
Mayinger Peter et al., In The Journal of Cell Biology, 2000
... The JNK inhibitor SP600125 was purchased from BIOMOL International, L.P ...
Vav1 Is a Component of Transcriptionally Active Complexes
Varin-Blank Nadine et al., In The Journal of Experimental Medicine, 1999
... terminal kinase (JNK) were purchased from Santa Cruz Biotechnology, Inc ...
In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes.
Blanke Steven R., In PLoS Pathogens, 1999
... MEK-2 (9125), p38-MAPK (9212), phospho-p38-MAPK (p38pT180-Y182, 9211), ERK (9102), phospho-ERK (ERKpT202-Y204, 9101), JNK (9252) and phospho-JNK (JNKpT183-Y185, 4668) and PD98059 were from Cell Signaling (Danvers, USA) ...
An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13.
Tompkins Stephen Mark, In PLoS ONE, 1999
... Mouse anti-ERK and anti-JNK antibodies as well as rabbit anti-phospho ERK and anti-phospho JNK antibodies (Cell Signaling), anti-cytochrome c, anti-influenza NS1, ...
Quantifying Lamella Dynamics of Cultured Cells by SACED, a New Computer-Assisted Motion Analysis.
Cimini Daniela, In PLoS ONE, 1998
... RhoA mAb, p-JNK Ab and Trio polyclonal Ab (clone D20) were purchased from Santa Cruz Biotechnology.
The effect of tranilast on experimental proliferative vitreoretinopathy.
Hung Chi-Feng et al., In Molecular Vision, 1998
... Antibodies raised against phospho-c-Jun N-terminal kinase (JNK) were from New England Biolabs, Inc ...
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
Tabas Ira et al., In The Journal of Cell Biology, 1997
... -terminal kinase (JNK)1/2, and JNK1/2 were purchased from Cell Signaling Technology ...
Phosphorylation of FADD/MORT1 and Fas by kinases that associate with the membrane-proximal cytoplasmic domain of Fas
Tschopp Jürg et al., In The Journal of Experimental Medicine, 1997
... Louis, Paris, France), anti–phospho-JNK (New England Biolabs), peroxidase- or Cy5-conjugated secondary ...
Phosphatidylinositol 3-kinase gamma mediates shear stress-dependent activation of JNK in endothelial cells
Walzel H et al., In Cell Death & Disease, 1997
... peptide, phospho-MKK3/6 (Ser189/Thr207) mAb, phospho-MKK7 (Ser271/Thr275) pAb, phospho-JNK (Thr183/Tyr185) mAb, phospho-MKK4 (Ser257/Thr261) pAb, and the JNK assay kit were from New England Biolabs (Frankfurt, Germany) ...
Suppression of an absolute defect in type IV pilus biogenesis by loss-of-function mutations in pilT, a twitching motility gene in Neisseria gonorrhoeae
Waldor Matt, In PLoS Biology, 1997
... (Ser63), P44/42 MAPK, phospho-p44/42 MAPK (Thr202/Tyr204), phospho-MAPKAPK2 (Thr334), p38 MAPK, phospho-p38 MAPK (Thr108/Tyr182), SAPK/JNK, and phospho-SAPK/JNK (Thr183/Tyr185) were purchased from Cell Signaling Technology (Beverly, Massachusetts, United ...
Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors
Watson Cheryl S et al., In Journal of Molecular Signaling, 1997
... Antibodies (Abs) used in the ERK and JNK phosphorylation studies (individually described below) were purchased from Cell Signaling (Danvers, MA) ...
Nuclear Factor of Activated T Cells Balances Angiogenesis Activation and Inhibition
Volpert Olga V. et al., In The Journal of Experimental Medicine, 1997
... A mouse JNK1 mAb (BD Biosciences), rabbit anti-JNK/SAPK1 pAb (Upstate ...
Visualizing the dynamics of T cell activationintracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
Siminovitch Katherine A. et al., In The Journal of Experimental Medicine, 1997
... (McGill Cancer Centre, Montreal, Quebec, Canada), respectively; and antiphospho-SAPK/JNK and anti-SAPK/JNK antibodies (reactive against all SAPK/JNK isoforms) from New England Biolabs.
Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b
Simon Hans-Uwe et al., In The Journal of Experimental Medicine, 1996
... Anti–Jun kinase (JNK) Ab (C-17) was from Santa Cruz Biotechnology ...
Src family-selective tyrosine kinase inhibitor, PP1, inhibits both FcεRI- and Thy-1-mediated activation of rat basophilic leukemia cells
Lowell Clifford A. et al., In The Journal of Experimental Medicine, 1996
... -terminal kinase (JNK) (Santa Cruz Biotechnology); anti-JNK1 (PharMingen); anti-Syk ...
The end of the (cell) line: methods for the study of apoptosis in vitro.
Deli Maria A., In PLoS ONE, 1994
... The ERK and JNK antibodies were from Cell Signaling Technology (Beverly, MA) ...
Fc∈RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling
Rivera Juan et al., In The Journal of Experimental Medicine, 1994
... A rabbit polyclonal antibody to Vav and a goat polyclonal antibody to JNK1 were from Santa Cruz Biotechnology.
Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells.
Burow Matthew E. et al., In Environmental Health Perspectives, 1994
... Louis, MO); UO126 (an ERK inhibitor) from Promega (Madison, WI); SP600125 (a JNK inhibitor) from BIOMOL Research Laboratories Inc ...
Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
Nerurkar Pratibha V., In PLoS ONE, 1993
... phospho-p38 (Thr180/Tyr182), phospho-Akt (Ser473), and ERK1/2 and rabbit monoclonal antibodies against human phospho-p65 (Ser536) and phospho-JNK (Thr183/Tyr185) were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes
Alonso Miguel A. et al., In The Journal of Experimental Medicine, 1991
... The anti-JNK and anti–IKK-α/β antibodies were purchased from Cell Signaling Technology ...
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes
Kitanaka C et al., In Cell Death & Disease, 1986
... antibody, anti-total ERK1/2 antibody, anti-phospho-ERK1/2(Thr180/Tyr182) antibody, anti-MEK1 antibody, anti-MEK2 antibody, anti-total p38MAPK antibody, anit-phospho-p38MAPK(Thr202/Tyr204) antibody, anti-phospho-JNK(Thr183/Tyr185) antibody, and anti-PARP antibody were from Cell Signaling Technology (San Jose, CA, ...
Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells
Patel Kamala D. et al., In The Journal of Experimental Medicine, 1984
... Anti-JNK antibody was obtained from Santa Cruz Biotechnology, Inc ...
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