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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Semaphorin 7A, GPI membrane anchor

JMH, Semaphorin 7A, Sema7A, CDw108
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, CD45, Plexin C1
Papers on JMH
Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration.
New
Buschow et al., Nijmegen, Netherlands. In J Immunol, Feb 2016
Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being highly expressed on activated primary myeloid and plasmacytoid DCs in human and mouse.
Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury.
New
Rosenberger et al., Tübingen, Germany. In Plos One, Dec 2015
Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutrophils into hypoxic tissue sites, yet, its role during lung injury is not well understood.
Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.
New
Espejo et al., Spain. In Mult Scler, Nov 2015
BACKGROUND: Studies in multiple sclerosis (MS) and in experimental models point to a critical role of semaphorin (sema)3A and sema7A in MS pathogenesis.
Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons.
New
Trudeau et al., Montréal, Canada. In Curr Biol, Oct 2015
Furthermore, we demonstrate that reducing axonal arborization by acting on axon guidance pathways with Semaphorin 7A reduces in parallel the basal rate of mitochondrial OXPHOS and the vulnerability of nigral DA neurons to the neurotoxic agents MPP(+) (1-methyl-4-phenylpyridinium) and rotenone.
Retrograde signaling for climbing fiber synapse elimination.
Review
New
Kano et al., Tokyo, Japan. In Cerebellum, Feb 2015
Here, we show that semaphorin3A (Sema3A) and semaphorin7A (Sema7A) mediate retrograde signals for elimination of redundant climbing fiber (CF) to Purkinje cell (PC) synapses in the developing cerebellum, a representative model of synapse elimination in the central nervous system.
Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.
Uzawa et al., Chiba, Japan. In Plos One, 2014
Of them, SEMA7A has been reported to have a chemotactic activity in neurogenesis and to be an immunomodulator; however, little is known about the relevance of SEMA7A in the behaviors of oral squamous cell carcinoma (OSCC).
Flaviviruses are neurotropic, but how do they invade the CNS?
Review
Neal, Cardiff, United Kingdom. In J Infect, 2014
CD8+ T cells are vital for clearance of WNF infected cells from the CNS, whereas TLR-3 and TLR-7 mediated anti-virus response through increased serum inflammatory cytokines to disrupt the BBB providing infected leucocytes and free virus access to the CNS (so called Trojan horse) Cellular virus attachment factors, promoting FV cell entry are widely distributed and include DC-SIGN (that detects complex carbohydrate molecules); Glycosamino glycans (GAG), Heparan sulphate(HSPG) Semaphorin 7A, Low Density Lipid receptors (LDLR); these are not FV specific virus entry receptors.
Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.
Impact
Kano et al., Tokyo, Japan. In Science, 2014
Conversely, knockdown of Sema7A, a membrane-anchored semaphorin, in Purkinje cells or either of its two receptors in climbing fibers impaired synapse elimination after P15.
JMH blood group system: a review.
Review
Johnson, Milwaukee, United States. In Immunohematology, 2013
The molecular basis of the JMH1- phenotype is not known; however, single nucleotide changes in the SEMA7A gene on chromosome 15 account for the other JMH antigens.
Semaphorin7A: branching beyond axonal guidance and into immunity.
Review
Iragavarapu-Charyulu et al., Boca Raton, United States. In Immunol Res, 2013
Semaphorin7A (SEMA7A) belongs to the "immune" semaphorin group and has been shown to play a crucial role in regulating immune responses.
Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development.
Review
Pasterkamp et al., Utrecht, Netherlands. In Semin Cell Dev Biol, 2013
The semaphorin family contains several secreted and transmembrane proteins, but only one GPI-anchored member, Semaphorin7A (Sema7A).
Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.
GeneRIF
Kumanogoh et al., Suita, Japan. In J Immunol, 2012
Sema7A plays crucial roles in suppressing intestinal inflammation through alphavbeta1 integrin, but also provides a novel mode of IL-10 induction via interactions between IECs and Mvarphis
Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.
GeneRIF
Giacobini et al., Torino, Italy. In Hum Mol Genet, 2012
GnRH-1 cells differentially express the Sema7 receptors beta1-integrin and Plexin C1 as a function of their migratory stage.
Semaphorin 7a links nerve regeneration and inflammation in the cornea.
GeneRIF
Jain et al., Chicago, United States. In Invest Ophthalmol Vis Sci, 2011
Sema7a is expressed constitutively in the cornea, and potently stimulates nerve regeneration and inflammatory cell influx.
Semaphorin 7A promotes angiogenesis in an experimental corneal neovascularization model.
GeneRIF
Azar et al., Chicago, United States. In Curr Eye Res, 2011
Sema7A was expressed in vascularized corneas and showed pro-angiogenic properties in our corneal model.
Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes.
GeneRIF
Sato et al., Tokyo, Japan. In J Dermatol Sci, 2011
Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.
Impact
GeneRIF
He et al., Chicago, United States. In Cell, 2010
Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
Impact
GeneRIF
Kikutani et al., Suita, Japan. In Nature, 2007
findings not only identify a function of Sema7A as an effector molecule in T-cell-mediated inflammation, but also reveal a mechanism of integrin-mediated immune regulation
Semaphorin 7A is a negative regulator of T cell responses.
Impact
Medzhitov et al., New Haven, United States. In Immunity, 2006
Semaphorin 7A (Sema7A) promotes axonal growth in the central nervous system.
Semaphorin 7A promotes axon outgrowth through integrins and MAPKs.
Impact
GeneRIF
Kolodkin et al., Baltimore, United States. In Nature, 2003
Sema7A enhancement of axon outgrowth requires integrin receptors and activation of MAPK signalling pathways
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