gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Heterogeneous nuclear ribonucleoprotein D-like

JKTBP, HNRPDL, JKTBP2, heterogeneous nuclear ribonucleoprotein D-like JKTBP, laAUF1
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011] (from NCBI)
Sponsored links
Papers on JKTBP
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.
Reboll et al., Hannover, Germany. In J Mol Biol, 2011
The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs.
Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R).
Wei et al., Chengdu, China. In Cell Biochem Funct, 2008
overexpression of JKTBP1 in LNCaP cells leads to abnormal cell proliferation
NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.
Nourbakhsh et al., Hannover, Germany. In Rna, 2007
The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity.
[The interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2].
Chen et al., Xiamen, China. In Shi Yan Sheng Wu Xue Bao, 2005
Study shows that there is interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2, indicating that JKTBP2 may have an important function in AD formation.
share on facebooktweetadd +1mail to friends