Infantile systemic hyalinosis in identical twins.
Hyderābād, India. In Intractable Rare Dis Res, Nov 2015
It is a rare, progressive, fatal autosomal recessive condition characterized by widespread deposition of hyaline material in many tissues caused by mutations in the anthrax toxin receptor 2 gene - ANTXR2.
Anti-infective immunoadhesins from plants.
Hayward, United States. In Plant Biotechnol J, Oct 2015
An immunoadhesin incorporating the cellular receptor for anthrax toxin, CMG2, potently blocks toxin activity in vitro and protects animals against inhalational anthrax.
Anthrax lethal and edema toxins in anthrax pathogenesis.
Bethesda, United States. In Trends Microbiol, 2014
The exotoxins secreted by B. anthracis use capillary morphogenesis protein 2 (CMG2) as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease.
Human genetic variation altering anthrax toxin sensitivity.
Stanford, United States. In Proc Natl Acad Sci U S A, 2012
results reveal extensive diversity in cell lethality dependent on anthrax toxin PA-mediated toxin binding and uptake, and identify individual differences in CMG2 expression level as a determinant of this diversity
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
Houston, United States. In Nat Genet, 2010
In addition to strong association with the major histocompatibility complex (MHC; P < 10(-800)), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7)).