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Anthrax toxin receptor 2

JHF, CMG2, capillary morphogenesis protein 2, ANTXR2, anthrax toxin receptor 2
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: TEM8, CAN, HAD, ACID, V1a
Papers on JHF
A complex role of anthrax toxin receptor 2 polymorphisms and capillary morphogenesis protein 2 in ankylosing spondylitis pathogenesis.
Sun et al., Beijing, China. In Clin Rheumatol, Feb 2016
UNASSIGNED: This study investigated the role of anthrax toxin receptor 2 (ANTXR2) gene polymorphisms and capillary morphogenesis protein 2 (CMG2) expression in susceptibility and pathogenesis to ankylosing spondylitis (AS) in the Han Chinese in Beijing.
Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis.
Jamshidi et al., Kīsh, Iran. In Rheumatol Int, Dec 2015
Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis.
Infantile systemic hyalinosis in identical twins.
Venugopal et al., Hyderābād, India. In Intractable Rare Dis Res, Nov 2015
It is a rare, progressive, fatal autosomal recessive condition characterized by widespread deposition of hyaline material in many tissues caused by mutations in the anthrax toxin receptor 2 gene - ANTXR2.
Anti-infective immunoadhesins from plants.
Hayden et al., Hayward, United States. In Plant Biotechnol J, Oct 2015
An immunoadhesin incorporating the cellular receptor for anthrax toxin, CMG2, potently blocks toxin activity in vitro and protects animals against inhalational anthrax.
Characterization of Protein-Protein Interfaces through a Protein Contact Network Approach.
Giuliani et al., Roma, Italy. In Front Bioeng Biotechnol, 2014
Homomeric forms of PA, complexes of PA bound to LF and to the endogenous receptor capillary morphogenesis gene 2 (CMG2) were analyzed.
Bacillus anthracis infections--new possibilities of treatment.
Kocik et al., Puławy, Poland. In Ann Agric Environ Med, 2014
The application of CpG oligodeoxynucleotides to boost the immune response elicited by Anthrax Vaccine Adsorbed and CMG2 protein complexes, also produced satisfying therapy results.
Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression.
Chen et al., Beijing, China. In Toxins (basel), 2014
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility.
Anthrax lethal and edema toxins in anthrax pathogenesis.
Leppla et al., Bethesda, United States. In Trends Microbiol, 2014
The exotoxins secreted by B. anthracis use capillary morphogenesis protein 2 (CMG2) as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease.
Key tissue targets responsible for anthrax-toxin-induced lethality.
Leppla et al., Bethesda, United States. In Nature, 2013
Here we generated cell-type-specific anthrax toxin receptor capillary morphogenesis protein-2 (CMG2)-null mice and cell-type-specific CMG2-expressing mice and challenged them with the toxins.
Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.
Liu et al., Bethesda, United States. In Biochem Biophys Res Commun, 2012
these results demonstrate that CMG2 is not required for normal mouse embryonic development but is indispensable for murine parturition
Identification of 2 novel ANTXR2 mutations in patients with hyaline fibromatosis syndrome and proposal of a modified grading system.
Hart et al., Marília, Brazil. In Am J Med Genet A, 2012
2 novel ANTXR2 mutations were identified in patients with hyaline fibromatosis syndrome
Human genetic variation altering anthrax toxin sensitivity.
Cohen et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
results reveal extensive diversity in cell lethality dependent on anthrax toxin PA-mediated toxin binding and uptake, and identify individual differences in CMG2 expression level as a determinant of this diversity
Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han.
Liu et al., Jinan, China. In Scand J Rheumatol, 2012
ANTXR2 might not be a susceptibility gene of Ankylosing Spondylitis in Chinese Han.
The dark sides of capillary morphogenesis gene 2.
van der Goot et al., Lausanne, Switzerland. In Embo J, 2012
Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix.
Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity.
Kitajewski et al., New York City, United States. In Plos One, 2011
we have discovered that ANTXR1 and ANTXR2 function as positive regulators of MT1-MMP activity.
[Bacillus anthracis: a molecular look at a famous pathogen].
Cataldi et al., Saudi Arabia. In Rev Argent Microbiol, 2011
Finally, the two anthrax toxin protective antigen receptors, ANTXR1/TEM8 and ANTXR2/CMG2, essential for the interaction of the pathogen with the host, are presented.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Wellcome Trust Case Control Consortium 2 (WTCCC2) et al., Bristol, United Kingdom. In Nat Genet, 2011
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
Brown et al., Houston, United States. In Nat Genet, 2010
In addition to strong association with the major histocompatibility complex (MHC; P < 10(-800)), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7)).
LRP6 holds the key to the entry of anthrax toxin.
Hultgren et al., Wichita, United States. In Cell, 2006
LRP6 acts as a coreceptor with either TEM8 or CMG2, the two previously identified receptors for anthrax toxin.
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Cohen et al., Stanford, United States. In Cell, 2006
Fluorescence microscopy and biochemical analyses showed that LRP6 enables toxin internalization by interacting at the cell surface with PA receptors TEM8/ATR and/or CMG2 to form a multicomponent complex that enters cells upon PA binding.
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