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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PHD finger protein 17

Jade-1, gene for Apoptosis and Differentiation in Epithelia
Top mentioned proteins: VHL, Histone, N-acetyl-beta-D-glucosaminidase, H4, Ubiquitin
Papers on Jade-1
Jade-1: its structure, regulation and functions in the renal cancer.
New
Pei et al., Xuzhou, China. In Curr Mol Med, Dec 2015
Jade-1 is originally identified by the yeast two-hybrid system as a protein partner of von Hippel-Lindau (pVHL) tumor suppressor, a well-known renal tumor suppressor.
The novel function of JADE1S in cytokinesis of epithelial cells.
Panchenko et al., Boston, United States. In Cell Cycle, 2014
JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin.
Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity.
Schermer et al., Freiburg, Germany. In J Biol Chem, 2014
The plant homeodomain zinc finger protein Jade-1 can act as an E3 ubiquitin ligase-targeting β-catenin for proteasomal degradation and concentrates at the centrosome and ciliary basal body in addition to the nucleus in interphase cells.
Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex.
Panchenko et al., Boston, United States. In Cell Cycle, 2013
HAT HBO1 interacts with 2 isoforms of JADE1: JADE1S and JADE1L.
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
Lu et al., Houston, United States. In Embo J, 2013
LncRNA-JADE transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex.
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
Cohen et al., Boston, United States. In Cancer Res, 2013
Plant homeodomain protein Jade-1 (PHF17) is a candidate renal tumor suppressor stabilized by pVHL.
Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration.
Panchenko et al., Boston, United States. In Am J Pathol, 2013
Two isoforms of JADE1, JADE1S and JADE1L, bind HBO1 and promote acetylation of histones in chromatin context.
Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.
Cohen et al., Boston, United States. In Hum Mol Genet, 2013
Jade-1 is a pro-apoptotic and growth suppressive ubiquitin ligase for beta-catenin and transcriptional coactivator associated with histone acetyltransferase activity that is stabilized by pVHL in a manner that correlates with risk of VHL renal disease.
Expression and clinical significance of von Hippel-Lindau downstream genes: Jade-1 and β-catenin related to renal cell carcinoma.
GeneRIF
Weng et al., Wenzhou, China. In Urology, 2012
RCC with a low expression of Jade-1 is associated with a poor outcome and decreased survival
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling.
GeneRIF
Schermer et al., Köln, Germany. In J Biol Chem, 2012
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling.
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
Struhl et al., Boston, United States. In Mol Cell, 2010
H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition, and coexpression of HBO1 and Jade-1 increases histone acetylation and MCM complex loading.
Beta-catenin gets jaded and von Hippel-Lindau is to blame.
Major et al., Seattle, United States. In Trends Biochem Sci, 2009
Among other roles, VHL can promote the stabilization of Jade-1.
HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.
Côté et al., Québec, Canada. In Mol Cell, 2009
A distinctive characteristic of HBO1 HAT complexes is the presence of three PHD finger domains in two different subunits: tumor suppressor proteins ING4/5 and JADE1/2/3.
Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex.
GeneRIF
Panchenko et al., Boston, United States. In J Biol Chem, 2008
Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.
Impact
GeneRIF
Cohen et al., Boston, United States. In Nat Cell Biol, 2008
The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1.
Role of the VHL (von Hippel-Lindau) gene in renal cancer: a multifunctional tumour suppressor.
Review
McKenna et al., Cork, Ireland. In Biochem Soc Trans, 2008
Additional functions of pVHL that may be important in preventing CCRCC tumorigenesis have been identified, including primary cilium maintenance, assembly of the extracellular matrix and roles in the stabilization of p53 and Jade-1 (gene for apoptosis and differentiation in epithelia).
Jade-1, a candidate renal tumor suppressor that promotes apoptosis.
GeneRIF
Cohen et al., Boston, United States. In Proc Natl Acad Sci U S A, 2005
Jade-1 may suppress renal cancer cell growth in part by increasing apoptosis.
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