Plant COP9 signalosome subunit 5, CSN5.
Chongqing, China. In Plant Sci, 2014
This highly conserved gene has been a subject of intense research in part because human Csn5 (Jab1) has been tightly linked to cancer.
Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins.
Montpellier, France. In Curr Protein Pept Sci, 2013
In eukaryotes, MPN domain-containing proteins are commonly found in association with other molecules in large protein complexes, where examples comprise; the 26S proteasome and the COP9 (Constitutive photomorphogenesis 9) signalosome complexes, including the MPN subunits, POH1 and Mov34, CSN5 and CSN6, respectively.
[MIF in head and neck cancer: a new therapeutic target ?].
In Rev Laryngol Otol Rhinol (bord), 2012
MIF binding to its receptor is responsible for the activation of several signaling pathways (ERK1/2 - MAPK, JAB1 - CSN5, PI3K - Akt), the inhibition of p53 and the stimulation of angiogenic factors including VEGF and IL-8.