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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inositol-trisphosphate 3-kinase B

Itpkb, IP3K, inositol 1,4,5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K-B
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: inositol 1,4,5-trisphosphate 3-kinase, Actin, CAN, OUT, V1a
Papers on Itpkb
Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma.
New
Jardin et al., Rouen, France. In Genes Chromosomes Cancer, Mar 2016
Novel genes such as XPO1, MFHAS1, and ITPKB were found particularly mutated, along with various cytokine-based signaling pathways.
Candidate genes for individual recognition in Polistes fuscatus paper wasps.
New
Toth et al., Ames, United States. In J Comp Physiol A Neuroethol Sens Neural Behav Physiol, Jan 2016
We identified four candidate genes (IP3K, IP3R, Nckx30C and Su(var)2-10) that were down-regulated in the presence of familiar individuals compared to single wasps and pairs of wasps meeting for the first time.
A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis.
New
Trobridge et al., Spokane, United States. In Oncotarget, Nov 2015
We repeatedly recovered integrated vector proviruses near genes (Itpkb, Ccdc12, and Nbeal2).
Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function.
Review
New
Koenig et al., Brussels, Belgium. In Adv Biol Regul, Oct 2015
Two of the three isoenzymes show an unexpected cytoskeletal localization for Itpka/b or at the leading edge for Itpkb.
The NO stimulator, Catestatin, improves the Frank-Starling response in normotensive and hypertensive rat hearts.
New
Cerra et al., Rende, Italy. In Nitric Oxide, Sep 2015
This effect was mediated by EE/IP3K/NOS/NO/cGMP/PKG, as revealed by specific inhibitors.
The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer.
Lu et al., Shanghai, China. In Plos One, 2014
Moreover, we performed dual luciferase reporter assay and Western blot on 6 targeted genes (FZD8, ITGA10, ITPKB, LRP5, PIAS1 andRUNX1) in small cell lung carcinoma cell line NCI-H82.
Expression of fibroblast growth factor receptor 1, fibroblast growth factor 2, phosphatidyl inositol 3 phosphate kinase and their clinical and prognostic significance in early and advanced stage of squamous cell carcinoma of the lung.
Ercolak et al., İstanbul, Turkey. In Int J Clin Exp Pathol, 2014
In this study, besides the signal transduction molecule phosphatidyl inositol-3-phosphate kinase (IP3K) p110α, we explored the expressions of fibroblast growth factor 2 (FGF2) and receptor-1 (FGFR1) in tumor tissue and also their clinical and prognostic significance in patients with early/advanced SqCLC.
Modulation of Epidermal Growth Factor Stimulated ERK Phosphorylation and Cell Motility by Inositol Trisphosphate Kinase.
Wells et al., Findlay, United States. In J Pharm Sci Pharmacol, 2014
In this study we have investigated the effect of modulation of intracellular IP3K activity by the use of an inhibitor, 2-trifluoromethyl [6-(4-nitrobenzyl)-purine] [IP3KI] and siRNA against IP3KB on EGF-induced ERK-phosphorylation and cell motility.
Establishing genomic/transcriptomic links between Alzheimer's disease and type 2 diabetes mellitus by meta-analysis approach.
Review
Karim et al., Jiddah, Saudi Arabia. In Cns Neurol Disord Drug Targets, 2014
Significantly changed expression of "myeloid leukemia cell differentiation protein 1; RAS guanyl releasing protein 1; S100 calcium-binding protein A8; prostaglandin- endoperoxide synthase 2; parvalbumin; endoplasmic reticulum aminopeptidase 1; phosphoglycerate kinase 1; Eukaryotic translation initiation factor 3 subunit F; Interleukin-1 beta; tubulin, beta 2A; glycine receptor alpha 1 and ribosomal protein S24" genes were highly associated with T2DM, whereas "neuronal differentiation 6; G-protein coupled receptor 83; phosphoserine phosphatase; bobby sox homolog or HMG box -containing protein 2; Glutathione S-transferase theta 1; alpha-2-glycoprotein 1 zinc-binding; Heat shock 70kDa protein 1B; transportin 1, Acidic leucine-rich nuclear phosphoprotein 32 family member B; Nuclear factor of activated T-cells 5; inositol 1,4,5-trisphosphate 3-kinase B; prenylcysteine oxidase 1 like" were found to be strongly related with AD.
A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells.
GeneRIF
Erneux et al., Brussels, Belgium. In Cell Signal, 2012
a specific increase in inositol 1,4,5-trisphosphate 3-kinase A and B (ITPKA and ITPKB) was observed upon hESCs spontaneous differentiation.
Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
GeneRIF
Mayr et al., Hamburg, Germany. In J Biol Chem, 2011
IP3KB not only regulates cytoplasmic Ca(2+) signals by phosphorylation of subplasmalemmal and cytoplasmic Ins(1,4,5)P(3) but may also be involved in modulating nuclear Ca(2+) signals generated from these nuclear envelope invaginations.
Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells.
GeneRIF
Schurmans et al., Brussels, Belgium. In Immunobiology, 2011
controls survival and prevents anergy in B cells
Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb).
Review
Maréchal et al., Brussels, Belgium. In Adv Enzyme Regul, 2010
Mice deficient for the B isoform of inositol 1,4,5-trisphosphate 3-kinase (Itpkb) develop profound alterations in T and B cells as well as in neutrophils and mast cells.
Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.
GeneRIF
Cooke et al., San Diego, United States. In J Immunol, 2009
B cells from Itpkb(-/-) Ig hen egg lysozyme mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling
New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
Review
Sauer et al., Los Angeles, United States. In Expert Opin Ther Targets, 2008
METHODS: We evaluate the potentials of inositol (1,4,5)trisphosphate 3-kinase B (ItpkB), Orai1 and UNC93B, three particularly interesting proteins that were recently identified through functional genomics, as targets in immune disorders.
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
GeneRIF
Luo et al., Boston, United States. In Proc Natl Acad Sci U S A, 2008
InsP3KB is also a physiological modulator of myelopoiesis.
Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.
Impact
Cooke et al., San Diego, United States. In Nat Immunol, 2007
Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb), which converts Ins(1,4,5)P3 to inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), had impaired B lymphocyte development and defective immunoglobulin G3 antibody responses to a T lymphocyte-independent antigen.
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations.
Review
Yang et al., Wuhan, China. In Cell Res, 2005
Therefore, plant IP3K should also play a crucial role in plant development.
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Impact
Mackay et al., L'Aquila, Italy. In Cancer Cell, 2004
This NGF-unresponsive isoform is oncogenic in NIH3T3 cells and promotes tumorigenic NB cell behavior in vitro and in vivo (cell survival, xenograft growth, angiogenesis) resulting from spontaneous tyrosine kinase activity and IP3K/Akt/NF-kappaB but not Ras/MAPK signaling.
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development.
Impact
Schurmans et al., Belgium. In Nat Immunol, 2003
Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection.
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