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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Integrin, alpha 9

ITGA9, integrin alpha 9
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, NotI, ACID, SET
Papers on ITGA9
MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma.
New
Qiu et al., Nanchang, China. In Tumour Biol, Dec 2015
Furthermore, our findings demonstrate that upregulating miR-125b significantly inhibits malignant phenotypes by repressing the expression of integrin alpha9 (ITGA9).
Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma.
New
Ernberg et al., Stockholm, Sweden. In Oncotarget, Nov 2015
Among ten candidate TSGs identified in chromosome 3 using NotI microarray, ITGA9 and WNT7A could be validated.
Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies.
New
Sawalha et al., Toledo, United States. In Ann Rheum Dis, Aug 2015
Common hypomethylated genes include ITGA9, encoding an α integrin.
Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.
Hugnot et al., Montpellier, France. In Stem Cells, 2015
This was paralleled with the induction of several angiogenesis-related factors most notably cytokines (heparin binding epidermal growth factor [HB-EGF], IL8, and PLGF), matrix metalloproteinases (MMP9), and adhesion proteins (vascular cell adhesion molecule 1 [VCAM1], intercellular adhesion molecule 1 [ICAM1], and integrin alpha 9 [ITGA9]).
Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay.
Hu et al., Stockholm, Sweden. In Clin Epigenetics, 2014
The resulting assay included EBNA1, LMP1, and three cellular TSGs: ITGA9, RASSF1A, and P16.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Three genes (BHLHE40, BCL6, and ITGA9) were tested for expression level alterations using qPCR, and downregulation associated with hypermethylation was shown in the majority of tumors.
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.
Feany et al., In Hum Mol Genet, 2014
Both CD2AP and FERMT2 have been previously implicated with roles in cell adhesion, and our screen additionally identifies a fly homolog of the human integrin adhesion receptors, ITGAM and ITGA9, as a modifier of Tau neurotoxicity.
Evaluation and integration of genetic signature for prediction risk of nasopharyngeal carcinoma in Southern China.
O'Brien et al., Wenzhou, China. In Biomed Res Int, 2013
Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3
Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer.
Pylkäs et al., Oulu, Finland. In Bmc Cancer, 2013
Four of these were singletons and disturbed the following genes: DCLRE1C, CASP3, DAB2IP and ITGA9, encoding proteins that are part of the TP53 and β-estradiol centered network.
Functional genomic assessment of phosgene-induced acute lung injury in mice.
Fabisiak et al., Pittsburgh, United States. In Am J Respir Cell Mol Biol, 2013
This integrative, functional approach revealed 14 candidate genes that included Atp1a1, Alox5, Galnt11, Hrh1, Mbd4, Phactr2, Plxnd1, Ptprt, Reln, and Zfand4, which had significant SNP associations, and Itga9, Man1a2, Mapk14, and Vwf, which had suggestive SNP associations.
Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer.
Zabarovsky et al., Moscow, Russia. In Epigenetics, 2013
Thirty genes, including tumor suppressors or candidates (for example, VHL, RBSP3/CTDSPL, ITGA9, LRRC3B, ALDH1L1, EPHB1) and genes previously unknown as cancer-associated (ABHD5, C3orf77, PRL32, LOC285375, FGD5 and others), showed methylation/deletion in 21-44% of tumors.
Refinement of chromosome 3p22.3 region and identification of a susceptibility gene for bipolar affective disorder.
Lopes-Cendes et al., Campinas, Brazil. In Am J Med Genet B Neuropsychiatr Genet, 2013
This SNP is located within intron 15 of the integrin alpha 9 (ITGA9) gene.
Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis.
Review
Chen et al., Taipei, Taiwan. In Ultrasound Obstet Gynecol, 2012
We evaluated clinical (hydrops vs. no hydrops) and genetic (mutations in the reported lymphedema-associated loci: VEGFR3, PTPN11, FOXC2, ITGA9) parameters, as well as treatment outcome.
Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.
GeneRIF
Lala et al., London, Canada. In Plos One, 2011
Differential capacity for VEGF-D production and integrin alpha 9 beta 1 expression by human breast cancer cell line MDA-MB-468LN jointly contributed to their lymphatic metastatic phenotype.
NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.
Zabarovsky et al., Stockholm, Sweden. In Int J Mol Sci, 2011
To check the results of NMA hybridizations several samples for four genes (LRRC3B, THRB, ITGA9 and RBSP3 (CTDSPL)) were bisulfite sequenced and confirmed the results of NMA hybridization.
Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors.
GeneRIF
Grigorieva et al., Novosibirsk, Russia. In Cell Adh Migr, 2011
Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors
Endostatin suppresses colorectal tumor-induced lymphangiogenesis by inhibiting expression of fibronectin extra domain A and integrin α9.
GeneRIF
Liang et al., Chongqing, China. In J Cell Biochem, 2011
endostatin reduces colorectal tumor-induced lymphangiogenesis, at least in part, by inhibiting EDA-integrin alpha9 pathway.
Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.
GeneRIF
Jones et al., London, United Kingdom. In J Pathol, 2011
expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype
Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site.
GeneRIF
Vlahakis et al., Rochester, United States. In J Biol Chem, 2011
the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells
Lymphangiogenic growth factors, receptors and therapies.
Review
Alitalo et al., Helsinki, Finland. In Thromb Haemost, 2003
Other factors that seem to be involved in lymphangiogenesis include the Tie/angiopoietin system, neuropilin-2 and integrin alpha 9. VEGF-C induces lymphatic vessel growth, but high levels of VEGF-C also resulted in blood vessel leakiness and growth.
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