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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha 5

ITGA5, Polypterus
alpha subunit that interacts with beta 1 subunit to form a fibronectin receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, fibronectin, HAD, V1a, ACID
Papers on ITGA5
Upregulation of microRNA-31 targeting integrin α5 suppresses tumor cell invasion and metastasis by indirectly regulating PI3K/AKT pathway in human gastric cancer SGC7901 cells.
Ma et al., Changchun, China. In Tumour Biol, Feb 2016
UNASSIGNED: To verify the hypothesis that upregulation of microRNA-31 (miR-31) targeting integrin α5 (ITGA5) suppresses tumor cell invasion and metastasis by indirectly regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in human SGC7901 gastric cancer (GC) cells.
Morphometric structural diversity of a natural armor assembly investigated by 2D continuum strain analysis.
Ortiz et al., Cambridge, United States. In J Struct Biol, Dec 2015
This study analyzes the spatially varying shape of individual ganoid scales as a structural element in a biological system, the exoskeleton of the armored fish Polypterus senegalus (bichir).
Expression of genes involved in cellular adhesion and ECM-remodelling correlates with poor survival of renal cancer patients.
Piekielko-Witkowska et al., Warsaw, Poland. In J Urol, Dec 2015
TGF-β1 induced expression of TGFBI, COL1A1, COL5A1, COL8A1, FN1, ITGA5, ITGAM, and TIMP1 in RCC-derived cell line.
Organization of the nitrergic neuronal system in the primitive bony fishes Polypterus senegalus and Erpetoichthys calabaricus (Actinopterygii: Cladistia).
González et al., Madrid, Spain. In J Comp Neurol, Dec 2015
UNASSIGNED: Cladistians are a group of basal actinopterygian fishes that constitute a good model to study primitive brain features, most likely present in the ancestral bony fishes.
Administration of tauroursodeoxycholic acid enhances osteogenic differentiation of bone marrow-derived mesenchymal stem cells and bone regeneration.
Lee et al., South Korea. In Bone, Nov 2015
In the present study, we examined whether TUDCA can promote osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMMSCs) by regulating Integrin 5 (ITGA5) associated with activation of ERK1/2 signal pathway and thereby enhance bone tissue regeneration by reducing apoptosis and the inflammatory response.
Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.
Clark et al., Norwich, United Kingdom. In Osteoarthritis Cartilage, Nov 2015
This microRNA was shown to target the ITGA5 gene directly (which encodes integrin alpha5) and inhibited adhesion to fibronectin (dependent on alpha5beta1 integrin).
miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression.
Lv et al., Guangzhou, China. In Am J Transl Res, 2014
Additionally, ITGA2 and ITGA5 were predicted as the target genes of miR-128.
A Fish Assemblage from the Middle Eocene from Libya (Dur At-Talah) and the Earliest Record of Modern African Fish Genera.
Jaeger et al., Poitiers, France. In Plos One, 2014
In the early nineteen sixties, Arambourg and Magnier found some freshwater fish (i.e., Polypterus sp., Siluriformes indet.
Developmental plasticity and the origin of tetrapods.
Larsson et al., Ottawa, Canada. In Nature, 2014
Polypterus is a member of the basal-most group of ray-finned fish (actinopterygians) and has many plesiomorphic morphologies that are comparable to elpistostegid fishes, which are stem tetrapods.
Natural flexible dermal armor.
Meyers et al., San Diego, United States. In Adv Mater, 2013
Here we seek to find the means by which Nature derives its protection by examining the scales from several fish (Atractosteus spatula, Arapaima gigas, Polypterus senegalus, Morone saxatilis, Cyprinius carpio), and osteoderms from armadillos, alligators, and leatherback turtles.
Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents.
Bix et al., College Station, United States. In J Clin Invest, 2011
elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin
Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis.
Jeoung et al., South Korea. In Mol Immunol, 2011
Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction.
Spatial association of the Cav1.2 calcium channel with α5β1-integrin.
Davis et al., Columbia, United States. In Am J Physiol Cell Physiol, 2011
Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 calcium channel current in rat arteriolar smooth muscle cells expressing Cav1.2.
Human bone marrow mesenchymal stem cells: a systematic reappraisal via the genostem experience.
Jorgensen et al., Le Kremlin-Bicêtre, France. In Stem Cell Rev, 2011
Thus we have described novel factors implicated in osteogenesis (FHL2, ITGA5, Fgf18), chondrogenesis (FOXO1A) and tenogenesis (Smad8).
Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.
Miller et al., Boston, United States. In Plos One, 2010
v beta 3 has a role in choroidal neovascularization in a rat model
Integrin-α5 coordinates assembly of posterior cranial placodes in zebrafish and enhances Fgf-dependent regulation of otic/epibranchial cells.
Riley et al., College Station, United States. In Plos One, 2010
itga5 coordinates cell migration into posterior placodes and augments Fgf signaling required for patterning of these tissues and cell survival in otic/epibranchial placodes
Innervation of lung and heart in the ray-finned fish, bichirs.
Fasulo et al., Messina, Italy. In Acta Histochem, 2008
The present review paper describes the presence of nerve fibers located in the muscle layers of the lung and its submucosa, the collection of unipolar neurons found in the submucosal and muscle layers of the glottis in a bichir species (Polypterus bichir bichir).
Materials design principles of ancient fish armour.
Ortiz et al., Cambridge, United States. In Nat Mater, 2008
Here, we present a multiscale experimental and computational approach that reveals the materials design principles present within individual ganoid scales from the 'living fossil' Polypterus senegalus.
Paraneurons in the gills and airways of fishes.
Licata et al., Messina, Italy. In Microsc Res Tech, 1997
In Polypterus and Amia the lungs have neuroendocrine cells that are apparently not innervated.
The cranial nerves of the Senegal bichir, Polypterus senegalus [osteichthyes: actinopterygii: cladistia].
Northcutt et al., Tübingen, Germany. In Brain Behav Evol, 1995
The organization of the roots, ganglia and peripheral distribution of the rami of the cranial nerves of larval and juvenile Senegal bichirs was examined with a wide range of techniques, including gross dissection and histological preparations.
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