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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha 11

ITGA11, integrin alpha 11
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, OUT, Msc, HAD, SET
Papers on ITGA11
FGF2 Overrides TGFβ1-Driven Integrin ITGA11 Expression in Human Dermal Fibroblasts.
Dominko et al., Slovenia. In J Cell Biochem, Oct 2015
Here we investigate the mechanism of a collagen I binding integrin α11 (ITGA11) deregulation in response to low oxygen-mediated FGF2 effects in dermal fibroblasts.
Mmu-miR-126a-3p plays a role in murine embryo implantation by regulating Itga11.
Yi et al., Chengdu, China. In Reprod Biomed Online, Sep 2015
Bioinformatic analysis predicted and luciferase activity assay confirmed that Itga11, a member of the integrin family, was a target gene of miR-126a-3p.
An epigenetically distinct breast cancer cell subpopulation promotes collective invasion.
Pearson et al., In J Clin Invest, May 2015
Functional analysis determined that DOCK10, ITGA11, DAB2, PDFGRA, VASN, PPAP2B, and LPAR1 are highly expressed in trailblazer cells and required to initiate collective invasion, with DOCK10 essential for metastasis.
Identification of miR-145 targets through an integrated omics analysis.
Pandey et al., Baltimore, United States. In Mol Biosyst, 2015
In our transcriptomic analysis, overexpression of miR-145 was found to suppress the expression of genes that are implicated in development of cancer such as ITGA11 and MAGEA4 in addition to previously described targets such as FSCN1, YES1 and PODXL.
Identification of susceptibility modules for coronary artery disease using a genome wide integrated network analysis.
Dong et al., Ningbo, China. In Gene, 2014
Our network analysis identified four susceptibility modules for CAD including a complex module that consisted of 15 functional inter-connected sub-modules, AGPAT3-AGPAT4-PPAP2B module, ITGA11-ITGB1 module and EMCN-SELL module.
Highlights of glycosylation and adhesion related genes involved in myogenesis.
Petit et al., Limoges, France. In Bmc Genomics, 2013
A functional study was performed on Itga11 and Chst5 encoding two highly up-regulated proteins.
Progesterone modulates integrin {alpha}2 (ITGA2) and {alpha}11 (ITGA11) in the pregnant cervix.
Chien et al., Providence, United States. In Reprod Sci, 2011
Integrin α11 (ITGA11) expression increased through mid-gestation, peaking on day 18 and decreasing through day 22 (ANOVA P < .001).
Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging.
Ginis et al., Israel. In Stem Cells Dev, 2011
Real-time polymerase chain reaction confirmed that expression of CD106, integrin alpha 11, and insulin-like growth factor-2 in MSCs was at least 10-fold higher than in fibroblasts; whereas expression of matrix metalloproteinase 1 and matrix metalloproteinase 3 was almost 100-fold lower.
Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.
Docheva et al., München, Germany. In Cell Death Dis, 2010
The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation.
Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources.
Oostendorp et al., München, Germany. In Exp Cell Res, 2010
These include previously identified molecules, but also novel markers like NOTCH3, JAG1, and ITGA11.
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
Gullberg et al., Bergen, Norway. In Matrix Biol, 2010
Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression.
Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle.
Barendse et al., Armidale, Australia. In Bmc Genet, 2009
RESULTS: To confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the ITGA11 (Integrin alpha 11) gene.
A role for alpha11beta1 integrin in the human periodontal ligament.
Bolstad et al., Bergen, Norway. In J Dent Res, 2009
is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1]
Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1.
Lukomski et al., Morgantown, United States. In J Biol Chem, 2009
analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.
Tsao et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2007
Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth.
Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor.
Gullberg et al., Bergen, Norway. In Mol Cell Biol, 2007
Integrin alpha11(-/-) mice are viable and fertile but display dwarfism with increased mortality, most probably due to severely defective incisors.
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Lin et al., Kao-hsiung, Taiwan. In Oncol Rep, 2006
To explore candidates, we conducted an oligonucleotide microarray study with three pairs of NSCLC and normal lung tissue, and determined 8 differentially expressed genes including the Human MutT homologue (hMTH1), Surfactant protein D (SPD), Human hyaluronan binding protein 2 (HABP2), Crystalline-mu (CRYM), Ceruloplasmin (CP), Integrin alpha-11 subunit (ITGA11), Collagen type XI alpha I (COL11A1), and Lung-specific X protein (Lun X).
Integrin alpha 11 is a novel type I interferon stimulated gene.
Kroon et al., Belo Horizonte, Brazil. In Cytokine, 2006
A new interferon stimulated gene. (Integrin alpha 11)
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