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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Integrin, alpha 11

ITGA11, integrin alpha 11
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on ITGA11
Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.
GeneRIF
Docheva et al., München, Germany. In Cell Death Dis, 2010
The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation.
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
GeneRIF
Gullberg et al., Bergen, Norway. In Matrix Biol, 2010
Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression.
A role for alpha11beta1 integrin in the human periodontal ligament.
GeneRIF
Bolstad et al., Bergen, Norway. In J Dent Res, 2009
is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1]
Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1.
GeneRIF
Lukomski et al., Morgantown, United States. In J Biol Chem, 2009
analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.
GeneRIF
Tsao et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2007
Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth.
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