Aminoacyl-tRNA synthetase inhibitors as potent antibacterials.
Nanjing, China. In Curr Med Chem, 2011
In this review, we examine the latest developments and structure-activity relationship (SAR) analysis of aminoacyl-tRNA synthetases inhibitors, including methionyl-tRNA synthetase, isoleucyl-tRNA synthetase and phenylalanyl-tRNA synthetase inhibitors.
Resistance to and synthesis of the antibiotic mupirocin.
Birmingham, United Kingdom. In Nat Rev Microbiol, 2010
Low-level resistance to the antibiotic arises by mutation of the mupirocin target, isoleucyl-tRNA synthetase, whereas high-level resistance is due to the presence of an isoleucyl-tRNA synthetase with many similarities to eukaryotic enzymes.