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Isoleucyl-tRNA synthetase 2, mitochondrial

Isoleucine-tRNA Ligase, IARS2
Top mentioned proteins: fibrillin-1, coupling factor 6, Calpain, ATPase, Ubiquitin
Papers on Isoleucine-tRNA Ligase
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
Ingelsson et al., Uppsala, Sweden. In Hum Mol Genet, Jan 2016
In Stage 1, two known (FTO and TMEM18) and six novel (PEX2, MTFR2, SSFA2, IARS2, CEP295 and TXNDC12) loci were associated with BMI (P < 2.8 × 10(-6) for 17 941 gene tests).
IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis.
Wang et al., In Neoplasma, Dec 2015
The purpose of this study was to investigate the potential role of Ileucyl-tRNA synthetase (IARS2) silencing in non-small cell lung cancer (NSCLC).
Expression of IARS2 gene in colon cancer and effect of its knockdown on biological behavior of RKO cells.
Chen et al., Kunming, China. In Int J Clin Exp Pathol, 2014
OBJECTIVE: To investigate the expression level of IARS2 gene in colon cancer tissues and various cell strains of the cancer; to explore cytologically the effect of IARS2 gene knockdown on proliferation, apoptosis and cell cycle of RKO cells in the cancer.
Mutation in the nuclear-encoded mitochondrial isoleucyl-tRNA synthetase IARS2 in patients with cataracts, growth hormone deficiency with short stature, partial sensorineural deafness, and peripheral neuropathy or with Leigh syndrome.
Samuels et al., Montréal, Canada. In Hum Mutat, 2014
Using SNP genotyping and whole-exome sequencing, we identified a single likely causal variant, a missense mutation in a conserved residue of the nuclear gene IARS2, encoding mitochondrial isoleucyl-tRNA synthetase.
Protein synthesis and degradation gene SNPs related to feed intake, feed efficiency, growth, and ultrasound carcass traits in Nellore cattle.
Ferraz et al., Pirassununga, Brazil. In Genet Mol Res, 2012
Genotypes were obtained for SNPs in the growth hormone receptor (GHR-1 and GHR-2); calpain (CAPN4751); calpastatin (UoGCAST); ubiquitin-conjugating enzyme 2I (UBE2I-1 and UBE2I-2); R3H domain containing 1 (R3HDM1-1, -2, -3, and -4), ring finger protein 19 (RNF19); proteasome 26S subunit, non-ATPase, 13 (PSMD13); ribosomal protein, large, P2 (RPLP2); and isoleucine-tRNA synthetase 2, mitochondrial (IARS2) genes.
Isoleucyl-tRNA synthetase levels modulate the penetrance of a homoplasmic m.4277T>C mitochondrial tRNA(Ile) mutation causing hypertrophic cardiomyopathy.
d'Amati et al., Roma, Italy. In Hum Mol Genet, 2012
Analysis of mitochondrial isoleucyl-tRNA synthetase revealed significantly higher expression levels in skeletal muscle and fibroblasts of the unaffected mother when compared with the proband, while the transient over-expression of the IARS2 gene in patient transmitochondrial cybrids improved cell viability.
Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.
Horsburgh et al., Edinburgh, United Kingdom. In J Cereb Blood Flow Metab, 2012
A total of 12 mitochondrial proteins (including respiratory chain proteins NDUFA11, NDUFS3, NDUF5B, ATP5J, as well as ETFA, CYB5B, ATP6V1A, HSPA1B, OXR1, GLUL, IARS2, and PHYHIPL) were significantly altered with respect to genotype, global ischemia, or their interaction (P<0.01).
Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.
Rocchi et al., Roma, Italy. In Cancer Genet Cytogenet, 2007
In the present work, the nine genes TGFB2, IARS2, MARK1, TAF1A, TP53BP2, ADPRT, including a very large gene ESRRG and two microRNA genes, MIRN194-1 and MIRN215, localized in the fragile site FRA1H, were investigated by polymerase chain reaction (PCR) for homozygous deletions and by real-time PCR for modification or loss of gene expression in a panel of 19 cancer cell lines.
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