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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ISL1 transcription factor, LIM/homeodomain

Isl-1, Islet-1
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LIM, Insulin, CAN, PDX-1, ACID
Papers using Isl-1 antibodies
Papers on Isl-1
Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.
Wang et al., In J Clin Invest, Dec 2015
We determined that expression of the myocyte-enriched protein cardiac ISL1-interacting protein (CIP, also known as MLIP) is reduced in patients with dilated cardiomyopathy.
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Nishimura et al., Kōbe, Japan. In Oncol Lett, Nov 2015
In the present study, the expression of 11 previously validated MRD markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) was determined in 23 pairs of PB and BM samples collected from seven high-risk neuroblastoma patients at the same time point, and the sample was scored as MRD-positive if one of the MRD markers exceeded the normal range.
Bone marrow minimal residual disease was an early response marker and a consistent independent predictor of survival after anti-GD2 immunotherapy.
Cheung et al., New York City, United States. In J Clin Oncol, Apr 2015
BM MRD before 3F8 treatment and after cycle 2 (postMRD) was measured using a four-marker panel (B4GALNT1, PHOX2B, CCND1, and ISL1) by quantitative reverse transcription polymerase chain reaction.
Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.
Okada et al., Japan. In Mol Brain, 2014
Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks.
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.
Forrest et al., Yokohama, Japan. In Front Genet, 2014
The data confirm NEUROD1 as a key positive regulator in the transcriptional regulatory network (TRN), and ISL1, and PROX1 as antagonists.
The Role of ARX in Human Pancreatic Endocrine Specification.
Kieffer et al., Vancouver, Canada. In Plos One, 2014
Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2.
Modern management of Merkel cell carcinoma.
Huber, Zürich, Switzerland. In Curr Opin Otolaryngol Head Neck Surg, 2014
Together with cytokeratin 20 (CK20), other biomarkers like human insulin gene enhancer-binding protein islet-1 (ISL1) and transcription factor OCT4 may provide improved methods for diagnosis and ultimately, therapy.
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.
Brendolan et al., Milano, Italy. In Immunity, 2013
Herein, we exploit a genetic lineage-tracing approach to show that splenic fibroblastic reticular cells (FRCs), follicular dendritic cells (FDCs), marginal reticular cells (MRCs), and mural cells, but not endothelial cells, originate from embryonic mesenchymal progenitors of the Nkx2-5(+)Islet1(+) lineage.
Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development.
Driever et al., Freiburg, Germany. In Dev Biol, 2012
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Cell therapy for left ventricular dysfunction: an overview for cardiac clinicians.
Chong, Seattle, United States. In Heart Lung Circ, 2012
These include populations from extra-cardiac sources (skeletal myoblasts, bone marrow derived mononuclear cells, endothelial progenitor cells, bone marrow or adipose derived mesenchymal stem cells and embryonic or induced pluripotent stem cells as well as newly discovered cardiac stem cell populations (isl1(+), c-kit(+), sca1(+), sca1(+)/pdgfrα(+), cardiosphere derived, cardiac side-population and epicardium derived cells).
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity.
Dobreva et al., Bad Nauheim, Germany. In Dev Cell, 2012
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
ISL1 common variant rs1017 is not associated with susceptibility to congenital heart disease in a Chinese population.
Chen et al., Nanjing, China. In Genet Test Mol Biomarkers, 2012
This is the first study which indicates that ISL1 common variant rs1017 may not play a role in sporadic CHD susceptibility in the Chinese population.
Origin of non-cardiac endothelial cells from an Isl1+ lineage.
Henderson et al., Newcastle upon Tyne, United Kingdom. In Febs Lett, 2012
These data define new roles for Isl1 in the developing embryo and demonstrate a contribution of Isl1-expressing progenitors to vascular endothelium in vivo.
Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.
Kawakami et al., Minneapolis, United States. In Development, 2012
Islet1 functions in two distinct processes: regulation upstream of the Hand2-Shh pathway and contributions to girdle development in embryonic mice.
Transcriptional regulation of α-cell differentiation.
Kaestner et al., Philadelphia, United States. In Diabetes Obes Metab, 2011
In vivo and in vitro studies have shown that preproglucagon transcription, and therefore the maintenance of α-cell function, is regulated by several factors, including forkhead box A1 (Foxa1), paired box 6 (Pax6), brain4 (Brn4) and islet-1 (Isl-1).
[Resident cardiac stem cells].
Parfenova et al., In Kardiologiia, 2010
Resident cardiac stem cells (CSC) were revealed during recent years on the basis of expression of c-kit, sca-1, MDR1, and islet-1 markers.
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages.
Chien et al., Boston, United States. In Nature, 2009
purified ISL1(+) primordial progenitors are capable of self-renewal and expansion before differentiation into the three major cell types in the heart
Multipotent islet-1 cardiovascular progenitors in development and disease.
Chien et al., Boston, United States. In Cold Spring Harb Symp Quant Biol, 2007
This current brief review highlights the discovery and delineation of the role of Islet-1 cardiovascular progenitors in the generation of diverse heart cell lineages and how the implications of these findings are revising our classification and thinking about congenital heart disease in general.
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.
Chien et al., Boston, United States. In Cell Stem Cell, 2007
Isl1(+) cardiovascular progenitors and their downstream progeny play a pivotal role in cardiogenesis and lineage diversification of the heart.
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.
Chien et al., Boston, United States. In Cell, 2007
We use genetic fate-mapping studies to document that isl1(+) precursors from the second heart field can generate each of these diverse cardiovascular cell types in vivo.
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