Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Kōbe, Japan. In Oncol Lett, Nov 2015
In the present study, the expression of 11 previously validated MRD markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) was determined in 23 pairs of PB and BM samples collected from seven high-risk neuroblastoma patients at the same time point, and the sample was scored as MRD-positive if one of the MRD markers exceeded the normal range.
Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells.
Japan. In Mol Brain, 2014
Treatment with GSK3β inhibitors during the initial phase of differentiation in combination with dual SMAD inhibition was sufficient to induce PAX6 (+) and SOX1 (+) neural progenitors within 1 week, and subsequent treatment with retinoic acid (RA) and purmorphamine, which activates sonic hedgehog (SHH) signaling, resulted in the highly efficient induction of HB9(+) and ISL-1(+) motor neurons within 2 weeks.
Modern management of Merkel cell carcinoma.
Zürich, Switzerland. In Curr Opin Otolaryngol Head Neck Surg, 2014
Together with cytokeratin 20 (CK20), other biomarkers like human insulin gene enhancer-binding protein islet-1 (ISL1) and transcription factor OCT4 may provide improved methods for diagnosis and ultimately, therapy.
Cell therapy for left ventricular dysfunction: an overview for cardiac clinicians.
Seattle, United States. In Heart Lung Circ, 2012
These include populations from extra-cardiac sources (skeletal myoblasts, bone marrow derived mononuclear cells, endothelial progenitor cells, bone marrow or adipose derived mesenchymal stem cells and embryonic or induced pluripotent stem cells as well as newly discovered cardiac stem cell populations (isl1(+), c-kit(+), sca1(+), sca1(+)/pdgfrα(+), cardiosphere derived, cardiac side-population and epicardium derived cells).
Transcriptional regulation of α-cell differentiation.
Philadelphia, United States. In Diabetes Obes Metab, 2011
In vivo and in vitro studies have shown that preproglucagon transcription, and therefore the maintenance of α-cell function, is regulated by several factors, including forkhead box A1 (Foxa1), paired box 6 (Pax6), brain4 (Brn4) and islet-1 (Isl-1).
[Resident cardiac stem cells].
In Kardiologiia, 2010
Resident cardiac stem cells (CSC) were revealed during recent years on the basis of expression of c-kit, sca-1, MDR1, and islet-1 markers.
Multipotent islet-1 cardiovascular progenitors in development and disease.
Boston, United States. In Cold Spring Harb Symp Quant Biol, 2007
This current brief review highlights the discovery and delineation of the role of Islet-1 cardiovascular progenitors in the generation of diverse heart cell lineages and how the implications of these findings are revising our classification and thinking about congenital heart disease in general.