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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ISG15 ubiquitin-like modifier

ISG15, UCRP, G1P2
ISG15 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha (IFNA; MIM 147660) and -beta (IFNB; MIM 147640) (Zhao et al., 2005 [PubMed 16009940]).[supplied by OMIM, Jul 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, MxA, STAT1, V1a
Papers on ISG15
ISG15 is upregulated in respiratory syncytial virus infection and reduces virus growth through protein ISGylation.
New
Martínez et al., Madrid, Spain. In J Virol, Feb 2016
Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein that is highly increased during viral infections and has been reported to play an antiviral or a proviral activity, depending on the virus.
Expression profile of interferon tau-stimulated genes in ovine peripheral blood leukocytes during embryonic death.
New
Atli et al., Diyarbakır, Turkey. In Theriogenology, Jan 2016
Compared with that on Day 0, receptor transporter protein 4 (RTP4) and ISG15 expression was upregulated on Day 15 and remained high until Day 21 in both groups, and RTP4 and ISG15 mRNA levels were attenuated on Days 23 and 25 only in the ED group (P < 0.001).
Role of the IFN I system against the VHSV infection in juvenile Senegalese sole (Solea senegalensis).
New
Garcia-Rosado et al., Málaga, Spain. In Vet Res, Dec 2015
In this study, the stimulation of the Senegalese sole IFN I by VHSV infections has been evaluated by the relative quantification of the transcription of several ISG (Mx, Isg15 and Pkr) after inoculation with marine (pathogenic) and freshwater (non-pathogenic) VHSV isolates.
[Molecular mechanism of idiopathic basal ganglia calcification].
Review
New
Liu et al., In Yi Chuan, Aug 2015
Recently, genetic studies have identified several genes associated with IBGC, including SLC20A2, PDGFRB, PDGFB, ISG15 and XPR1.
Host susceptibility to non-tuberculous mycobacterial infections.
Review
New
Holland et al., Bethesda, United States. In Lancet Infect Dis, Aug 2015
So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection.
Monogenic autoinflammatory diseases: Cytokinopathies.
Review
New
Masters et al., Australia. In Cytokine, Aug 2015
Another example of this is interferon (IFN) and the interferonopathies, with mutations in the sensors STING and MDA5, the upstream signalling regulator AP1S3, and a downstream inhibitor of IFN signalling, ISG15.
The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.
Review
New
Mesecar et al., West Lafayette, United States. In Antiviral Res, Mar 2015
Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.
Impact
Pellegrini et al., Wuhan, China. In Nature, 2015
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β-dependent antiviral immunity in mice.
USP18 downregulation in peripheral blood mononuclear cells predicts nonresponse to interferon-based triple therapy in patients with chronic hepatitis C, genotype 1: a pilot study.
Sperl et al., Praha, Czech Republic. In Ther Clin Risk Manag, 2014
PATIENTS AND METHODS: Expression of IFNG, IFNLR1, and interferon-sensitive genes CXCL9, IFI16, IFI27, ISG15, and USP18 in peripheral blood mononuclear cells was assessed before and during the initial 12 weeks of treatment.
ISG15 as a novel prognostic biomarker for hepatitis B virus-related hepatocellular carcinoma.
Zuo et al., Changsha, China. In Int J Clin Exp Med, 2014
IFN-stimulated gene 15 (ISG15) is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli.
Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.
Review
Morley et al., Brighton, United Kingdom. In Translation (austin), 2014
Both of these events can be regulated by post-translational modification by ubiquitin or Ubls (ubiquitin-like modifiers) such as SUMO or ISG15.
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
Impact
GeneRIF
Casanova et al., New York City, United States. In Science, 2012
ISG15 plays an essential role as an IFN-gamma-inducing secreted molecule for optimal antimycobacterial immunity.
Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15.
GeneRIF
Chung et al., Seoul, South Korea. In J Clin Invest, 2012
ISG15 as a tumor suppressor via its conjugation to a tp63 splice variant
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells.
GeneRIF
Sankar et al., New Orleans, United States. In Exp Biol Med (maywood), 2012
results suggest that the aberrant activation of the ISG15 pathway confers a motile phenotype to breast cancer cells by disrupting cell architecture and stabilizing proteins involved in cell motility, invasion and metastasis
Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells.
GeneRIF
Geng et al., Tianjin, China. In Virol Sin, 2011
Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells.
HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells.
GeneRIF
Versteeg et al., New York City, United States. In Plos One, 2011
Data show that the HerC6 N-terminal RCC1-like domain (RLD) allows ISG15 conjugation.
NEDD8 pathways in cancer, Sine Quibus Non.
Review
Impact
Ohh et al., Toronto, Canada. In Cancer Cell, 2011
There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin.
Emerging role of ISG15 in antiviral immunity.
Review
Impact
GeneRIF
Chen et al., Dallas, United States. In Cell, 2010
In addition to cellular ISGylation targets, recent reports implicate viral proteins as targets of ISG15 modification; these studies provide fresh insights into the antiviral mechanisms of ISG15.[Review]
Interferon-inducible antiviral effectors.
Review
Impact
Williams et al., Australia. In Nat Rev Immunol, 2008
Gene targeting studies have distinguished four main effector pathways of the IFN-mediated antiviral response: the Mx GTPase pathway, the 2',5'-oligoadenylate-synthetase-directed ribonuclease L pathway, the protein kinase R pathway and the ISG15 ubiquitin-like pathway.
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