GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Iroquois related homeobox 3
Irx3
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] (from
NCBI)
Top mentioned proteins:
Irx1, FTO, fibrillin-1, HAD, CAN
Papers on
Irx3
Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice.
New
Changzhou, China. In Mol Med Report, Jan 2016
Thioflavin‑S staining was performed to detect senile plaques and reverse-transcription quantitative polymerase chain reaction was used to assess iroquois homeobox protein 3 (IRX3) and obesity‑associated genes, while western blot analysis was used for β‑secretase 1 (BACE1), insulin‑degrading enzyme (IDE) and neprilysin (NEP) detection.
Association of FTO and IRX3 genetic variants to obesity risk in north India.
New
Lucknow, India. In Ann Hum Biol, Dec 2015
Recent genetic studies suggest that obesity associated FTO and IRX3 are functionally linked and many effects due to genetic variants in FTO gene act through IRX3.
Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context.
New
Uppsala, Sweden. In Hum Genet, Nov 2015
However, this same also contains several regulatory DNA elements that affect the expression of IRX3 and IRX5, which respectively, are located approximately 500 kb and 1.2 Mbp downstream from the BMI-associated FTO locus.
Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias.
New
Tokyo, Japan. In Eur Heart J, Nov 2015
Irx3/IRX3 encodes a transcription factor specifically expressed in the His-Purkinje system in the heart.
BAC transgenic zebrafish reveal hypothalamic enhancer activity around obesity associated SNP rs9939609 within the human FTO gene.
New
Sydney, Australia. In Genesis, Oct 2015
However, other studies have shown that the FTO gene is part of the regulatory domain of the neighboring IRX3 gene and that enhancers in FTO intron 1 regulate IRX3.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
New
Impact
Macedonia. In N Engl J Med, Oct 2015
The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation.
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
New
Taiwan. In Biochem Biophys Res Commun, Sep 2015
These FTO variations were recently shown to affect IRX3 and the exact function of FTO is still controversial.
9B.09: IDENTIFICATION OF MARKERS PREDICTIVE FOR MALIGNANT BEHAVIOR OF PHEOCHROMOCYTOMAS AND PARAGANGLIOMAS.
New
Delft, Netherlands. In J Hypertens, Jun 2015
Five genes showed an FDR below 0.01 and were overexpressed in malignant tumours with a ratio higher than 4, including Contactin 4 (CNTN4), Iroquois Homeobox 3 (IRX3), and Sulfatase 2 (SULF2).
The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.
Review
New
Beijing, China. In Curr Obes Rep, Mar 2015
It has been recently suggested that although the obesity related SNPs reside in the first intron of FTO, they may not only impact FTO but mediate their obesity effects via nearby genes (notably RPGRIP1L and IRX3).
Comparison of forward light scatter estimations using Shack-Hartmann spot patterns and a straylight meter.
New
Manchester, United Kingdom. In J Cataract Refract Surg, Feb 2015
PURPOSE: To determine whether an unmodified commercial wavefront aberrometer (irx3) can be used to estimate forward light scattering and how this assessment matches estimations obtained from the C-Quant straylight meter.
Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue.
Oulu, Finland. In Sci Rep, 2014
Recent findings suggest that these variants affect the homeobox protein IRX3.
Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.
Odense, Denmark. In Genome Med, 2014
Finally, we compare our variant data with a previous study describing IRX3 and FTO interactions in this region.
Obesity and FTO: Changing Focus at a Complex Locus.
Review
Impact
Cambridge, United Kingdom. In Cell Metab, 2014
Two recent reports now indicate that obesity-associated SNPs appear functionally connected not with FTO but with two neighboring genes: IRX3 and RPGRIP1L.
The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.
Review
Cambridge, United Kingdom. In Mol Cell Endocrinol, 2014
Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity.
Obesity-associated variants within FTO form long-range functional connections with IRX3.
Impact
Chicago, United States. In Nature, 2014
Here we show that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3.
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.
GeneRIF
San Francisco, United States. In Proc Natl Acad Sci U S A, 2011
Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins
Cell wall composition contributes to the control of transpiration efficiency in Arabidopsis thaliana.
GeneRIF
Bristol, United Kingdom. In Plant J, 2010
involved in the control of transpiration efficiency
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
GeneRIF
Bergen, Norway. In Proc Natl Acad Sci U S A, 2010
IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes.
Identification of cellulose synthase AtCesA7 (IRX3) in vivo phosphorylation sites--a potential role in regulating protein degradation.
GeneRIF
York, United Kingdom. In Plant Mol Biol, 2007
AtCesA7 is phosphorylated in vivo at two serine residues.
Interactions between MUR10/CesA7-dependent secondary cellulose biosynthesis and primary cell wall structure.
GeneRIF
Norwich, United Kingdom. In Plant Physiol, 2006
CesA7 has a role in cellulose biosynthesis, primary, and secondary cell wall structure.
