Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice.
Changzhou, China. In Mol Med Report, Jan 2016
Thioflavin‑S staining was performed to detect senile plaques and reverse-transcription quantitative polymerase chain reaction was used to assess iroquois homeobox protein 3 (IRX3) and obesity‑associated genes, while western blot analysis was used for β‑secretase 1 (BACE1), insulin‑degrading enzyme (IDE) and neprilysin (NEP) detection.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Macedonia. In N Engl J Med, Oct 2015
The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation.