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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Iroquois related homeobox 2

Irx2, Irx6, iro7
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: Irx1, Interleukin-2, HAD, CAN, Irx3
Papers on Irx2
Immunostimulatory Activity of the Cytokine-Based Biologic, IRX-2, on Human Papillomavirus-Exposed Langerhans Cells.
New
Kast et al., New York City, United States. In J Interferon Cytokine Res, Jan 2016
The cell-derived cytokine-based biologic, IRX-2, consists of multiple well-defined cytokines and is broadly active on various immune cell subsets.
Markers for Distinguishing Cultured Human Corneal Endothelial Cells from Corneal Stromal Myofibroblasts.
New
Yamagami et al., Kōbe, Japan. In Curr Eye Res, Dec 2015
Iroquois homeobox 2 (IRX2) gene was a marker that distinguished CSMFs from cultured human CECs by RT-PCR.
IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.
New
Wang et al., Shanghai, China. In Mol Med Report, Sep 2015
Our previous studies have demonstrated that IRX2 is overexpressed and is important in cell proliferation and invasion.
Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.
New
Gisselsson et al., Lund, Sweden. In Cancer Lett, Mar 2015
In addition, a novel IRX2-TERT fusion transcript was identified in one case.
Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Review
New
Pinnick et al., Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.
Wikman et al., Hamburg, Germany. In Bmc Cancer, 2014
Using expression profiling on early stage primary breast tumors, low IRX2 expression was previously shown to be associated with the presence of DTCs in the bone marrow, suggesting a possible role of IRX2 in the early steps of metastasis formation.
The Role of ARX in Human Pancreatic Endocrine Specification.
Kieffer et al., Vancouver, Canada. In Plos One, 2014
Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2.
Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features.
Zakrzewska et al., Łódź, Poland. In Bmc Cancer, 2014
The most prominent differences were noted for IRX2, PAX3, CXCL14, LHX2, SIX6, CNTN1 and SIX1 genes expression even within different compartments of the supratentorial region.
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
Impact
Melbye et al., Copenhagen, Denmark. In Nat Genet, 2014
Several of the identified regions harbor genes with key roles in embryonic development (including HOXA4, IRX5, IRX6 and EYA1).
Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease.
Kanai et al., In Int J Cancer, 2014
DNA methylation levels of hallmark genes for each cluster, such as IRX2, HOXD8, SPARCL1, RGS5 and EI24, were again correlated with clinicopathological characteristics in the validation cohort.
Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway.
Wang et al., Shanghai, China. In Mol Med Report, 2014
Thus, this study focused on the expression and roles of IRX2 in the development of osteosarcoma.
A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.
Chapman et al., Knoxville, United States. In Plos One, 2013
Both SNPs are proximal to the IRX1 and IRX2 genes, which are required for neural specification.
Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
GeneRIF
Willman et al., Albuquerque, United States. In Blood, 2012
Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination.
GeneRIF
Leung et al., West Lafayette, United States. In Plos One, 2011
The retinal lamination issue in the Irx7-deficient retinas is likely caused by the attenuation of the neurite outgrowth
Preclinical studies with IRX-2 and thymosin alpha1 in combination therapy.
Review
Hadden et al., United States. In Ann N Y Acad Sci, 2010
In animal studies, the combination of IRX-2 and Talpha1 (IRX-3) increased T-cell numbers compared to either alone during recovery from hydrocortisone mediated reduction.
A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3.
GeneRIF
Schneider-Maunoury et al., Paris, France. In Dev Biol, 2009
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 to activate the expression of anterior hindbrain markers, such as krox20.
Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.
GeneRIF
Joos et al., Heidelberg, Germany. In Genes Chromosomes Cancer, 2006
IRX2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
Gateways to clinical trials.
Review
Prous et al., Barcelona, Spain. In Methods Find Exp Clin Pharmacol, 2004
This issue focuses on the following selection of drugs: 101M, 166Ho-DOTMP, 3-AP; Abatacept, abetimus sodium, ACR-16, adefovir dipivoxil, alefacept, AMD-070, aminolevulinic acid hexyl ester, anatumomab mafenatox, anti-CTLA-4 MAb, antigastrin therapeutic vaccine, AP-12009, AP-23573, APC-8024, aripiprazole, ATL-962, atomoxetine hydrochloride; Bevacizumab, bimatoprost, bortezomib, bosentan, BR-1; Calcipotriol/betamethasone dipropionate, cinacalcet hydrochloride, clofazimine, colchicine, cold-adapted influenza vaccine trivalent, CRM197; Desloratadine, desoxyepothilone B, diethylhomospermine; Edodekin alfa, efalizumab, elcometrine, eletriptan, enfuvirtide, entecavir, EP-2101, eplerenone, erlotinib hydrochloride, etoricoxib, everolimus, exherin, ezetimibe; Febuxostat, fluorescein lisicol, fosamprenavir calcium, frovatriptan; Hemoglobin raffimer, HSPPC-96, human insulin; Imatinib mesylate, insulin detemir, insulin glargine, IRX-2, istradefylline, IV gamma-globulin, ixabepilone; Kahalalide F; L-759274, levodopa/carbidopa/entacapone, licofelone, lonafarnib, lopinavir, lurtotecan, LY-156735; MAb G250, mecasermin, melatonin, midostaurin, muraglitazar; Nesiritide, nitronaproxen; O6-Benzylguanine, olmesartan medoxomil, olmesartan medoxomil/hydrochlorothiazide, omapatrilat, oral insulin; Parecoxib sodium, PCK-3145, peginterferon alfa-2a, peginterferon alfa-2b, peginterferon alfa-2b/ ribavirin, pemetrexed disodium, peptide YY3-36, PG-CPT, phenoxodiol, pimecrolimus, posaconazole; Rasagiline mesilate, rDNA insulin, RG228, rimonabant hydrochloride, rosuvastatin calcium, rotigotine hydrochloride; S-3304, safinamide mesilate, salcaprozic acid sodium salt, SDZ-SID-791, SGN-30, soblidotin, squalamine; Telmisartan/hydrochlorothiazide, testosterone gel, TF(c)-KLH conjugate vaccine, TH-9507, theraloc, tipifarnib, tocilizumab, travoprost; ValboroPro, valdecoxib, veglin, voriconazole; Ximelagatran.
The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain.
GeneRIF
Schneider-Maunoury et al., Paris, France. In Development, 2004
iro7 has a dual function in the hindbrain of the zebrafish embryo: it is required for the proper positioning of the prospective r4/r5 boundary and it promotes neurogenesis in the anterior hindbrain
Immunodeficiency and cancer: prospects for correction.
Review
Hadden, New York City, United States. In Int Immunopharmacol, 2003
In studies of combination immunotherapy in lymphocytopenic squamous cell head and neck cancer patients using IRX-2 (18 patients) and IRX-2 plus thymosin alpha(1) (IRX-3) in IRX-2-refractory patients (7 patients), marked increases in CD(45)RA(+) 'naïve' T cells (>250/mm(3)) were observed.
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