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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Iroquois related homeobox 1

Irx1, Irx5
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Irx3, Irx2, Irx4, SET, CAN
Papers on Irx1
Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5.
Zuo et al., Xiamen, China. In J Hazard Mater, Feb 2016
Further findings indicated that miR-1, which was depressed by Nkx2.5, might play a fundamental role in mediating cardiac hypertrophy and arrhythmia via its target genes Mef2a and Irx5 after HBCD treatment.
North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.
Stone et al., Copenhagen, Denmark. In Ophthalmology, Jan 2016
Next-generation sequencing of 2 individuals with MCDR3-linked NCMD revealed a 900-kb duplication that included the entire IRX1 gene (V5).
Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State.
Crump et al., Los Angeles, United States. In Dev Cell, Dec 2015
Further, both zebrafish Irx7 and mouse IRX1 are able to repress cartilage matrix production in a murine chondrogenic cell line.
Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context.
Schiöth et al., Uppsala, Sweden. In Hum Genet, Nov 2015
However, this same also contains several regulatory DNA elements that affect the expression of IRX3 and IRX5, which respectively, are located approximately 500 kb and 1.2 Mbp downstream from the BMI-associated FTO locus.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
Kellis et al., Macedonia. In N Engl J Med, Oct 2015
The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation.
Identifying novel biomarkers of gastric cancer through integration analysis of single nucleotide polymorphisms and gene expression profile.
Hou et al., Beijing, China. In Int J Biol Markers, Jul 2015
In the regulatory network, transcription factor forkhead box L1 (FOXL1) regulated 26 DEGs with risk associated SNP loci, including Iroquois homeobox 1 (IRX1) rs11134044, sex determining region Y (SRY)-box1 (SOX1) rs9549447 and msh homeobox 1 (MSX1) rs41451149.
IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.
Wang et al., In J Clin Invest, May 2015
Using methylated DNA immunoprecipitation (MeDIP) and microarray expression analysis to screen for metastasis-associated genes, we identified Iroquois homeobox 1 (IRX1).
The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog.
Durand et al., Paris, France. In Dev Biol, 2015
We find that the presumptive (pre)-ZLI domain expresses barhl2, otx2 and irx3, whereas the thalamus territory caudally bordering the pre-ZLI expresses barhl2, otx2 and irx1/2 and early on irx3.
Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.
Elgar et al., Odense, Denmark. In Genome Med, 2014
As well as confirming previous findings across the interval, we identify a further novel age-dependent association upstream of IRX5 that imposes a similar burden on BMI to the FTO locus.
Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis.
Casali et al., Barcelona, Spain. In Embo Rep, 2014
We also show that this genetic interaction is conserved in human CRC cells, where the Iro/IRX proteins IRX3 and IRX5 diminish the response to TGF-β.
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
Melbye et al., Copenhagen, Denmark. In Nat Genet, 2014
Several of the identified regions harbor genes with key roles in embryonic development (including HOXA4, IRX5, IRX6 and EYA1).
Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.
Hui et al., Toronto, Canada. In Dev Cell, 2014
Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1.
A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.
Chapman et al., Knoxville, United States. In Plos One, 2013
Both SNPs are proximal to the IRX1 and IRX2 genes, which are required for neural specification.
Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.
Reversade et al., Singapore, Singapore. In Nat Genet, 2012
Our findings suggest that IRX proteins integrate combinatorial transcriptional inputs to regulate key signaling molecules involved in the ontogeny of multiple organs during embryogenesis and homeostasis.
IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer.
Yu et al., Shanghai, China. In Oncogene, 2011
enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion.
Helicobacter pylori induces promoter hypermethylation and downregulates gene expression of IRX1 transcription factor on human gastric mucosa.
Yu et al., Shanghai, China. In J Gastroenterol Hepatol, 2011
Helicobacter pylori infection contributes to IRX1 promoter methylation in gastric mucosa.
Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma.
Yu et al., Shanghai, China. In Oncogene, 2010
IRX1 could potentially serve as a biomarker for gastric cancer.
HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas.
Eng et al., Cleveland, United States. In Genes Chromosomes Cancer, 2010
Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9.
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
Bruneau et al., Toronto, Canada. In Cell, 2005
Irx5 establishes the cardiac ventricular repolarization gradient.
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