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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fc receptor-like 4

IRTA1, FCRL4, FcRH4, Fc receptor-like 4
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: CD27, FCRL, CD20, HAD, IRTA2
Papers on IRTA1
Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
New
Amirghofran et al., Shīrāz, Iran. In Horm Metab Res, Aug 2015
Overexpression of FCRL4 was observed only in GD patients compared to controls.
Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
New
Ehrhardt et al., Toronto, Canada. In J Immunol, Jul 2015
FCRL4 is an immunoregulatory receptor expressed by a subpopulation of memory B cells.
Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis.
New
Scheel-Toellner et al., Birmingham, United Kingdom. In Ann Rheum Dis, May 2015
FcRL4(+) and FcRL4(-) B cells sorted from synovial fluid were analysed for cytokine expression using Taqman low-density arrays.
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
New
Greenhouse et al., San Francisco, United States. In Plos Pathog, May 2015
Additionally, in contrast to previous reports, we found upregulation of Fc receptor-like 5 (FCRL5), but not FCRL4, on atMBCs.
Skewed B cells in chronic hepatitis C virus infection maintain their ability to respond to virus-induced activation.
New
Mondelli et al., Pavia, Italy. In J Viral Hepat, Apr 2015
The proportion of B cells expressing the marker of exhaustion Fc receptor-like 4 (FcRL4) was generally low even though significantly higher in the patients' memory B-cell compartment compared with HD, and a positive correlation was found between the frequencies of the patients' TLM FcRL4+ B cells and serum alanine aminotransferase and histological activity index at liver biopsy.
Case-only designs for exploring the interaction between FCRL4 gene and suspected environmental factors in patients with ankylosing spondylitis.
New
Pan et al., Hefei, China. In Inflammation, Apr 2015
The aim of this study was to explore the interaction between FCRL4 gene and environmental factors in patients with ankylosing spondylitis.
Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism.
New
Song et al., Shanghai, China. In Mol Med Report, Mar 2015
The results showed that PE patients exhibited significantly increased expression levels of the B‑cell receptor genes LYN, CD22, SYK, BTK, PTPRC and NFAM1, whereas expression levels of FYN, FCRL4 and LAX1 were significantly decreased compared to those of the control group.
Nodal reactive and neoplastic proliferation of monocytoid and marginal zone B cells: an immunoarchitectural and molecular study highlighting the relevance of IRTA1 and T-bet as positive markers.
Stein et al., Berlin, Germany. In Histopathology, 2013
By immunohistochemistry, IRTA1 and/or T-bet expression was found in all reactive lesions and in 90% of neoplastic lesions.
MYC expression and distribution in normal mature lymphoid cells.
Cattoretti, Monza, Italy. In J Pathol, 2013
Follicular mantle, isotype-switched memory B cells and FcRH4/IRTA1+ B cells express MYC in a wide range of levels and are small non-proliferating CDKN1B/p27-positive or -negative resting B lymphocytes.
IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas.
Pileri et al., Perugia, Italy. In Histopathology, 2012
METHODS AND RESULTS: Two thousand one hundred and four peripheral lymphomas of various types were immunostained with a monoclonal antibody against immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), which recognizes the equivalents of MZ in human lymphoid tissues other than spleen.
Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population.
Pan et al., Hefei, China. In Clin Rheumatol, 2012
We hypothesized that FCRL4 may be a key gene for ankylosing spondylitis (AS) development.
Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.
GeneRIF
Colonna et al., Saint Louis, United States. In J Immunol, 2012
In cellular binding assays, as a bona fide receptor FcRL4 binds efficiently to immunoglobulin (Ig)A.
CpG array analysis of histone H3 lysine 4 trimethylation by chromatin immunoprecipitation linked to microarrays analysis in peripheral blood mononuclear cells of IgA nephropathy patients.
Dai et al., Chongqing, China. In Yonsei Med J, 2012
For further validation, we selected 4 key relevant genes (FCRL4, GALK2, PTPRN2 and IL1RAPL1) to study.
FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.
GeneRIF
Pierce et al., Rockville, United States. In Blood, 2012
Data suggest that expression of FcRL4 in B-cells results in inhibition of BCR signaling at point of Syk phosphorylation by mechanism that involves phosphorylation of FcRL4 and its association with SHP-1/SHP-2.
Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.
Fauci et al., Bethesda, United States. In J Clin Invest, 2011
The strongest effects were observed with the putative inhibitory receptors Fc receptor-like-4 (FCRL4) and sialic acid-binding Ig-like lectin 6 (Siglec-6).
Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area.
GeneRIF
Pierce et al., Rockville, United States. In J Immunol, 2009
FCRL4 is located on atypical memory B cells population significantly expanded in Plasmodium falciparum-exposed Malian adults and children
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
GeneRIF
Shokri et al., Tehrān, Iran. In Cancer Immunol Immunother, 2009
Down-regulation of FCRL4 is associated with acute lymphoblastic leukemia.
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
GeneRIF
Shokri et al., Tehrān, Iran. In Int J Cancer, 2008
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.
Impact
Dalla-Favera et al., New York City, United States. In Immunity, 2001
By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families.
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