I-BAR domains, IRSp53 and filopodium formation.
Singapore, Singapore. In Semin Cell Dev Biol, 2010
Cdc42 and its effector IRSp53 (insulin receptor phosphotyrosine 53 kDa substrate) have been shown to be strong inducers of filopodium formation.
The beta-thymosin/WH2 fold: multifunctionality and structure.
Philadelphia, United States. In Ann N Y Acad Sci, 2007
This paper discusses the relationship between structure and function of the beta-thymosin/WH2 fold on the basis of four examples: (1) actin monomer sequestration (thymosin-beta4), (2) actin filament nucleation (WASP-Arp2/3 complex, Lmod, and spire), (3) actin filament elongation (Ena/VASP), and (4) cytoskeleton scaffolding (IRSp53 and MIM).