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Insulin receptor substrate 4

IRS-4, insulin receptor substrate-4
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, IRS-1, IRS-2, Insulin-Like Growth Factor I, CAN
Papers on IRS-4
Whole exome sequencing in a case of sporadic multiple meningioma reveals shared NF2, FAM109B, and TPRXL mutations, together with unique SMARCB1 alterations in a subset of tumor nodules.
New
Rey et al., Madrid, Spain. In Cancer Genet, Jun 2015
Mutations in other genes, such as IRS4, GULP1, NHSL1, and C10orf53, accounted for one alteration in each meningioma nodule.
Adherence of Candida sp. to host tissues and cells as one of its pathogenicity features.
Review
Kurnatowski et al., Łódź, Poland. In Ann Parasitol, 2014
Various researchers specify a range of genes which contribute to adhesion, such as: CZF1, EFG1, TUP1, TPK1, TPK2, HGC1, RAS1, RIM101, VPS11, ECM1, CKA2, BCR1, BUD2, RSR1, IRS4, CHS2, SCS7, UBI4, UME6, TEC1 and GAT2.
[Monitoring the thermal plume from coastal nuclear power plant using satellite remote sensing data: modeling, and validation].
Shi et al., In Guang Pu Xue Yu Guang Pu Fen Xi, 2014
The infrared scanner (IRS), on board of HJ-1B, has an infrared channel IRS4 with 300 m and 4-days as its spatial and temporal resolution.
Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.
Mizuno et al., Sendai, Japan. In J Biol Chem, 2014
Co-precipitation assays revealed the direct endogenous binding of IRS4 to SSH1.
Genomics of uterine leiomyomas: insights from high-throughput sequencing.
Review
Vahteristo et al., Helsinki, Finland. In Fertil Steril, 2014
A minority of leiomyomas were also found to display deletions within the COL4A5-COL4A6 genes, leading to upregulation of the adjacent gene IRS4.
Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.
Howell et al., San Diego, United States. In Biochem Pharmacol, 2014
However, proteomic analysis did identify an interaction of CTR1 with IRS-4 and this was confirmed by co-immunoprecipitation from HEK cells expressing either FLAG-CTR1 or myc-CTR1.
Proliferation and migration of hepatoblastoma cells are mediated by IRS-4 via PI3K/Akt pathways.
Ding et al., Zhengzhou, China. In Int J Clin Exp Med, 2013
Levels of IRS-4 (insulin receptor substrate-4) in hepatoblastoma cells from the patients, HepG2 and HuH-6 cell lines were measured by Western Blot analysis, and they were all found significantly higher than those of normal hepatic cells.
Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance.
Al Suwaidan et al., Riyadh, Saudi Arabia. In Diagn Pathol, 2013
mRNA expression of Sirt7, INSR, IRS-1, IRS-2, IRS-4, IGF-1, IGF-2, MDR-1, MRP-1, BCRP was measured by qPCR and Sirt7 by standard Western blotting.
[Effects of peroxisome proliferator-activated receptors γ on the expression of insulin receptor substrate-4 gene in rat cortical neurons and mouse brain].
Wang et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2013
OBJECTIVE: To investigate the effect of peroxisome proliferator-activated receptors γ (PPARγ) on insulin receptor substrate-4 (IRS-4) gene expression in the brain.
Effect of IRS4 levels on PI 3-kinase signalling.
MacKintosh et al., Dundee, United Kingdom. In Plos One, 2012
In contrast, the function of IRS4 is not well understood.
Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.
Howell et al., Bar Harbor, United States. In Bmc Genomics, 2012
Finally, insulin signaling, in particular the down-regulation of the insulin receptor substrate 4 (Irs4) gene, may be an important event in the transition from age-related changes to Alzheimer's disease specific-changes.
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.
Review
Martelli et al., Greenville, United States. In Oncotarget, 2012
Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing.
Nuclear IRS-1 and cancer.
Review
Trojanek et al., New Orleans, United States. In J Cell Physiol, 2012
The family of insulin receptor substrates (IRS) consists of four proteins (IRS-1-IRS-4), which were initially characterized as typical cytosolic adaptor proteins involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling.
Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes.
Bennett et al., Tampa, United States. In J Integr Omics, 2012
The major constituents of the EGFR del complex (USB3B, GRB2, ERRFI, HSP7C, GRP78, HSP71) and the Grb2 complex (ARHG5, SOS1, ARG35, CBL, CBLB, PTPRA, SOS2, DYN2, WIPF2, IRS4) were identified.
Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.
GeneRIF
Li et al., Houston, United States. In Cancer Epidemiol, 2012
We genotyped single-nucleotide polymorphisms of IGF1, IGF2, IGF1R, IGF2R, IGFBP1, IGFBP3, IGFBP5, IRS1, IRS2, and IRS in pancreatic cancer patients
The insulin receptor substrate 4 gene (IRS4) is mutated in paediatric T-cell acute lymphoblastic leukaemia.
GeneRIF
Johansson et al., In Br J Haematol, 2011
Study for the first time identified IRS4 mutations in T-ALL.
The insulin receptor substrate-4 (IRS-4) gene and schizophrenia: no evidence for a main genetic factor, however one report of a single schizophrenia patient with a mutation.
GeneRIF
Hongslo et al., Stockholm, Sweden. In Neuro Endocrinol Lett, 2010
IRS-4 gene is not of importance for aetiology of the vast majority of schizophrenia cases, but a single patient with schizophrenia and a mutation in IRS-4 points to that the insulin signalling system is of interest in the search for schizophrenia genes
Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation.
GeneRIF
Mulholland et al., Ann Arbor, United States. In Bmc Neurosci, 2010
The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling.
Association between body mass index and insulin receptor substrate-4 (IRS-4) gene polymorphisms in patients with schizophrenia.
GeneRIF
Persson et al., Stockholm, Sweden. In Neuro Endocrinol Lett, 2010
This study clearly demonstrates associations between body mass index and IRS-4 variants in schizophrenia patients, but not in healthy controls, pointing to a possible involvement of IRS-4 in the control of body weight in schizophrenia.
[Emerging rickettsioses].
Review
Bandi et al., Milano, Italy. In Parassitologia, 2004
IRS4.
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