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Insulin receptor substrate 2

IRS-2, insulin receptor substrate-2
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, IRS-1, Akt, V1a, CAN
Papers using IRS-2 antibodies
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms
Tsilibary Effie C., In PLoS ONE, 1989
... The rabbit polyclonal anti-IRS-1 and anti-IRS-2 antibodies were from Millipore UK Ltd (Watford, UK) and the mouse monoclonal anti-CaMK4 antibody was from Clontech (Oxford, UK) ...
Papers on IRS-2
Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in Neuroblastoma.
Mason et al., Delaware, United States. In J Pharmacol Exp Ther, Feb 2016
Shc, an adapter protein that transmits IGF-1 signaling through the MAPK pathway, was sequestered in autophagosomes; whereas IRS-2, an adapter protein that transmits IGF-1 signaling through the Akt pathway, was unaffected by cathepsin inhibition.
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Ling et al., Copenhagen, Denmark. In Diabetologia, Feb 2016
The most strongly upregulated genes were ELOVL6, FADS2 and NNAT; in contrast, INSR, IRS2 and the SLC27A2 fatty acid transporter showed decreased expression after HFO.
IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms.
Traina et al., Campinas, Brazil. In Oncotarget, Feb 2016
Activated JAK2 was found to be associated with the insulin receptor substrate 2 (IRS2) in non-hematological cells.
Glucose induces mouse beta cell proliferation via IRS2, mTOR and cyclin D2 but not the insulin receptor.
Alonso et al., Worcester, United States. In Diabetes, Feb 2016
Using mice lacking insulin signaling intermediate IRS2, we confirmed that hyperglycemia-induced beta cell proliferation requires IRS2 both in vivo and ex vivo.
The genomic landscape of response to EGFR blockade in colorectal cancer.
Velculescu et al., Torino, Italy. In Nature, Nov 2015
Amplifications and sequence changes in the tyrosine kinase receptor adaptor gene IRS2 were identified in tumours with increased sensitivity to anti-EGFR therapy.
Association of the G1057D polymorphism in insulin receptor substrate 2 gene with type 2 diabetes mellitus: a meta-analysis.
Jia et al., China. In J Diabetes Complications, Jul 2015
OBJECTIVES: The G1057D polymorphism in insulin receptor substrate (IRS)-2 gene is associated with type 2 diabetes mellitus (T2DM) risk, but results in published literatures are controversial.
Recent progress in the genetics of diabetic microvascular complications.
Chuang et al., Taipei, Taiwan. In World J Diabetes, Jul 2015
However, most of the identified risk loci could not be replicated by independent studies with a few exceptions including those in ELMO1, FRMD3, CARS, MYO16/IRS2, and APOL3-MYH9 genes.
Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.
Huang et al., Kao-hsiung, Taiwan. In Plos One, 2014
We examined two iCCA cell lines and 86 cases of intrahepatic cholangiocarcinoma to analyze copy number of three target genes, including cullin 4A (CUL4A), insulin receptor substrate 2 (IRS2), and transcription factor Dp-1 (TFDP1) at 13q34 by quantitative real-time polymerase chain reaction.
[The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle].
Karczewska-Kupczewska et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
It increases insulin-dependent IRS2 phosphorylation and Akt activation.
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
Horita et al., Tokyo, Japan. In Biomed Res Int, 2014
In proximal tubules, Akt mediates insulin signaling via insulin receptor substrate 2 (IRS2) and stimulates sodium-bicarbonate cotransporter (NBCe1), resulting in increased sodium reabsorption.
IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.
White, Boston, United States. In Diabetes Obes Metab, 2014
Understanding how metabolism and nutrient homeostasis integrates with life span and neurodegeneration is a complicated undertaking.
A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Kuo et al., Stanford, United States. In Nat Med, 2013
Notably, liver-specific constitutive activation of HIF-2α, but not HIF-1α, was sufficient to augment hepatic insulin signaling through direct and indirect induction of insulin receptor substrate-2 (Irs2), an essential insulin receptor adaptor protein.
Downregulation of IRS2 in myelodysplastic syndrome: a possible role in impaired hematopoietic cell differentiation.
Traina et al., Campinas, Brazil. In Leuk Res, 2012
Defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in myelodysplastic syndrome.
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.
White et al., Boston, United States. In Cell Metab, 2012
Deletion of Foxo1 from LepR-b neurons in Lepr(DeltaIrs2) mice normalized energy balance.
Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet.
Terauchi et al., Yokohama, Japan. In Endocrinology, 2012
dipeptidyl peptidase-4 inhibitor vildagliptin has an effect on glucose tolerance and beta-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.
Pedarzani et al., London, United Kingdom. In Plos One, 2011
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
[Regulation of hepatic lipid metabolism by adiponectin via IRS-2 phosphorylation in OLETF rats].
Xue et al., Guangzhou, China. In Zhonghua Yi Xue Za Zhi, 2011
Adiponectin may affect the signaling pathway of hepatic insulin via tyrosine phosphorylation of IRS-2.
The Lin28/let-7 axis regulates glucose metabolism.
Daley et al., Boston, United States. In Cell, 2011
These phenomena occur, in part, through the let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2.
Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.
Kadowaki et al., Tokyo, Japan. In Cell Metab, 2011
We show here that adiponectin upregulates IRS-2 through activation of signal transducer and activator of transcription-3 (STAT3).
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